Sin Nombre virus prevalence from 2014–2017 in wild deer mice, Peromyscus maniculatus , on five of the California Channel Islands

2021 ◽  
Author(s):  
John L. Orrock ◽  
Brian M. Connolly ◽  
Peter W. Guiden ◽  
Jennifer L. Chandler ◽  
Gebbiena M. Bron ◽  
...  
Keyword(s):  
Peromyscus Maniculatus ◽  
Channel Islands ◽  
Deer Mice ◽  
Sin Nombre Virus ◽  
Virus Prevalence ◽  
California Channel Islands ◽  
Wild Deer

scholarly journals Comparison of Estimators for Monitoring Long-Term Population Trends in Deer Mice,Peromyscus maniculatus, on the California Channel Islands

2018 ◽  
Vol 78 (3) ◽  
pp. 496-509 ◽  
Author(s):  
Catherin A. Schwemm ◽  
Charles A. Drost ◽  
John L. Orrock ◽  
Timothy J. Coonan ◽  
Thomas R. Stanley
Keyword(s):  
Peromyscus Maniculatus ◽  
Population Trends ◽  
Channel Islands ◽  
Deer Mice ◽  
California Channel Islands

scholarly journals Development and Characterization of a Sin Nombre Virus Transmission Model in Peromyscus maniculatus

Viruses ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 183 ◽  
Author(s):  
Bryce Warner ◽  
Derek Stein ◽  
Bryan Griffin ◽  
Kevin Tierney ◽  
Anders Leung ◽  
...  
Keyword(s):  
Peromyscus Maniculatus ◽  
Deer Mouse ◽  
Virus Transmission ◽  
Transmission Model ◽  
Deer Mice ◽  
Sin Nombre Virus ◽  
Infection Model ◽  
Main Driver ◽  
Heat Shock Responses

In North America, Sin Nombre virus (SNV) is the main cause of hantavirus cardiopulmonary syndrome (HCPS), a severe respiratory disease with a fatality rate of 35–40%. SNV is a zoonotic pathogen carried by deer mice (Peromyscus maniculatus), and few studies have been performed examining its transmission in deer mouse populations. Studying SNV and other hantaviruses can be difficult due to the need to propagate the virus in vivo for subsequent experiments. We show that when compared with standard intramuscular infection, the intraperitoneal infection of deer mice can be as effective in producing SNV stocks with a high viral RNA copy number, and this method of infection provides a more reproducible infection model. Furthermore, the age and sex of the infected deer mice have little effect on viral replication and shedding. We also describe a reliable model of direct experimental SNV transmission. We examined the transmission of SNV between deer mice and found that direct contact between deer mice is the main driver of SNV transmission rather than exposure to contaminated excreta/secreta, which is thought to be the main driver of transmission of the virus to humans. Furthermore, increases in heat shock responses or testosterone levels in SNV-infected deer mice do not increase the replication, shedding, or rate of transmission. Here, we have demonstrated a model for the transmission of SNV between deer mice, the natural rodent reservoir for the virus. The use of this model will have important implications for further examining SNV transmission and in developing strategies for the prevention of SNV infection in deer mouse populations.

Long‐Term Patterns of Immune Investment by Wild Deer Mice Infected with Sin Nombre Virus

2010 ◽  
Vol 83 (5) ◽  
pp. 847-857 ◽  
Author(s):  
Erin M. Lehmer ◽  
Jeremy D. Jones ◽  
Mariana G. Bego ◽  
Johanna M. Varner ◽  
Stephen St. Jeor ◽  
...  
Keyword(s):  
Deer Mice ◽  
Sin Nombre Virus ◽  
Wild Deer

scholarly journals Sin Nombre Virus Does Not Impair Respiratory Function of Wild Deer Mice

1997 ◽  
Vol 78 (2) ◽  
pp. 661-668 ◽  
Author(s):  
C. S. O'Connor ◽  
J. P. Hayes ◽  
S. C. S. Jeor
Keyword(s):  
Respiratory Function ◽  
Deer Mice ◽  
Sin Nombre Virus ◽  
Wild Deer

scholarly journals Sin Nombre Virus Infection in Deer Mice, Channel Islands, California

2008 ◽  
Vol 14 (12) ◽  
pp. 1965-1966 ◽  
Author(s):  
John L. Orrock ◽  
Brian F. Allan
Keyword(s):  
Virus Infection ◽  
Channel Islands ◽  
Deer Mice ◽  
Sin Nombre Virus

scholarly journals Development of an ELISA to detect Sin Nombre virus-specific IgM from deer mice (Peromyscus maniculatus)

2008 ◽  
Vol 151 (2) ◽  
pp. 204-210 ◽  
Author(s):  
Mariana G. Bego ◽  
Darcy Bawiec ◽  
Deepa Dandge ◽  
Benjamin Martino ◽  
Denise Dearing ◽  
...  
Keyword(s):  
Peromyscus Maniculatus ◽  
Deer Mice ◽  
Sin Nombre Virus

Sin Nombre Virus Shedding Patterns in Naturally Infected Deer Mice (Peromyscus maniculatus) in Relation to Duration of Infection

2008 ◽  
Vol 8 (1) ◽  
pp. 97-100 ◽  
Author(s):  
David Safronetz ◽  
Michael A. Drebot ◽  
Harvey Artsob ◽  
Tyler Cote ◽  
Kai Makowski ◽  
...  
Keyword(s):  
Peromyscus Maniculatus ◽  
Deer Mice ◽  
Sin Nombre Virus ◽  
Virus Shedding ◽  
Duration Of Infection
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