SYNTHESIS AND CHARACTERIZATION OF HETEROCYCLIC CHALCONES CONTAINING HALOGENATED THIOPHENES

2015 ◽  
Vol 77 (3) ◽  
Author(s):  
Helmi Mohammed Al-Maqtari ◽  
Joazaizulfazli Jamalis ◽  
Hasnah Mohd Sirat
Keyword(s):  
Sodium Hydroxide ◽  
Spectral Data ◽  
13C Nmr ◽  
Basic Medium ◽  
Synthesis And Characterization ◽  
Schmidt Reaction ◽  
Synthetic Compounds ◽  
1H And 13C Nmr ◽  
Heterocyclic Aldehydes

Heterocyclic chalcones containing halogenated thiophenes were synthesized. The first step was to synthesize 3-acetyl-2,5-dichlorothiophene and 2-acetyl-5-chlorothiophene as heterocyclic ketones by using Friedel-Crafts acylation. The ketones were then used to synthesize thiophene chalcones through Claisen-Schmidt reaction with the respective heterocyclic aldehydes such as 5-bromothiophene-2-carbaldehyde, 3-methyl-2-thiophene carboxaldehyde and 2-thiophene carboxaldehyde with 3-acetyl-2,5-dichlorothiophene or 2-acetyl-5-chlorothiophene in presence of basic medium, sodium hydroxide to form the corresponding chalcones. Structures of the synthetic compounds were confirmed by IR, MS, 1H and 13C NMR spectral data.

Synthesis and Spectral Characterization of New S-Alkylated 1,2,4-Triazoles as Potential Biological Agents

2017 ◽  
Vol 68 (10) ◽  
pp. 2436-2439
Author(s):  
Stefania Felicia Barbuceanu ◽  
Laura Ileana Socea ◽  
Constantin Draghici ◽  
Elena Mihaela Pahontu ◽  
Theodora Venera Apostol ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Spectral Data ◽  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Ethyl Bromide ◽  
Spectral Characterization ◽  
Basic Medium ◽  
Phenacyl Bromide

In the work we presented the behavior of 5-(4-(4-X-phenylsulfonyl)phenyl)-4-(n-propyl)-2H-1,2,4-triazole-3(4H)-thiones (X= Cl or Br) with some alkylation agents. Thus, new S-alkylated 1,2,4-triazole derivatives were synthesized by reaction of the corresponding 1,2,4-triazole-3-thione derivatives with different �-halogenated compounds (ethyl bromide, ethyl chloroacetate or phenacyl bromide), in basic medium. The structures of synthesized compounds were elucidated by spectral data (1H-NMR, 13C-NMR, mass spectrometry) and elemental analysis.

scholarly journals Synthesis and Characterization of 1-phenyl-3-methyl-4-stearoylpyrazol-5-one and Its Lanthanum(III) and Tungsten(VI) Complexes

2020 ◽  
pp. 140-151
Author(s):  
A. I. C. Ehirim ◽  
C. K. Enenebeaku ◽  
C. Asimole ◽  
M. O. C. Ogwuegbu ◽  
E. N. O. Ejike
Keyword(s):  
Elemental Analysis ◽  
13C Nmr ◽  
Synthesis And Characterization ◽  
Conductivity Measurements ◽  
Melting Points ◽  
1H And 13C Nmr ◽  
Solubility Profile ◽  
Uv Visible ◽  
Metal Ligand

The ligand, 1-phenyl-3-methyl-4-stearoylpyrazol-5-one (HSPy), and its La(III) and W(VI) complexes were synthesized and characterized spectroscopically using elemental analysis, UV-visible, IR, 1H and 13C NMR. Physical properties such as colour, melting points, conductivity measurements and solubility profile were also investigated. La(III) and W(VI) reacted with the ligand in the metal-ligand mole ratios of 1:3 and 1:2 to form neutral complexes of diaquo-trischelate La(SPy)3.2H2O and dioxoaquo-bischelate, WO2(SPy)2.H2O respectively.

scholarly journals SYNTHESIS AND NMR SPECTRAL CHARACTERIZATION OF NOVEL 2,3-POLYMETHYLENEPYRIDO[2,3-D]PYRIMIDIN-4-ONES

2015 ◽  
Vol 11 (8) ◽  
pp. 3873-3875 ◽  
Author(s):  
Hamid Utkirovich Khodjaniyazov
Keyword(s):  
Spectral Data ◽  
13C Nmr ◽  
Phosphorus Oxychloride ◽  
Spectral Characterization ◽  
1H And 13C Nmr

We have synthesized of novel 2,3-polymethylenepyrido[2,3-d]pyrimidin-4-ones via condensation of the 2-aminonicotinic acid together with lactams in the presence of phosphorus oxychloride. The structures of the newly synthesized pyrido[2,3-d]pyrimidines were confirmed by 1H and 13c NMR spectral data.

scholarly journals Synthesis and Spectral Characterization of Some New Substituted Bis-spirocyclohexanones Derived from Acetone

2018 ◽  
Vol 6 (4) ◽  
pp. 155-159
Author(s):  
Mohammed S. Hussein ◽  
Abdul Wahab J. Al-Hamdany ◽  
Rana A. Saeed
Keyword(s):  
Spectral Data ◽  
13C Nmr ◽  
Michael Addition ◽  
Spectral Characterization ◽  
Schmidt Reaction ◽  
Substituted Benzaldehydes

Diarylidene acetones (DAA) (1-5) had been prepared by the condensation of acetone with substituted benzaldehydes via Claisen-Schmidt reaction, DAA’s brought to condense with anthrone to afford the title compounds (6-10) through Michael addition. The structures of the products were suggested in the light of spectral data (UV, IR, 1H&13C-NMR).

scholarly journals Synthesis and characterization of tris[butyl-(1-methyl-3phenyl-propyl)-dithiocarbamato]cobalt(III) seskvitoluen

2002 ◽  
Vol 67 (2) ◽  
pp. 123-126 ◽  
Author(s):  
Goran Kaludjerovic ◽  
Vesna Djinovic ◽  
Srecko Trifunovic ◽  
Ismet Hodzic ◽  
Tibor Sabo
Keyword(s):  
Nmr Spectroscopy ◽  
Electronic Absorption ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Sodium Salt ◽  
13C Nmr Spectroscopy ◽  
Bidentate Ligand ◽  
Synthesis And Characterization ◽  
1H And 13C Nmr

Anew bidentate ligand butyl-(1-methyl-3-phenyl-propyl)-dithiocarbamate (bm?pdtc) was prepared, as the sodium salt. In the reaction of hexaaminecobalt(III) chloride with Nabm?pdtc, the corresponding tris[butyl-(1-methyl-3-phenyl-propyl)-dithiocarbamato]cobalt(III) [Co(bm?pdtc)3]?complex was prepared. The complex was characterized by elemental analysis, infrared, electronic absorption, 1H and 13C-NMR spectroscopy.

SYNTHESIS AND CHARACTERIZATION OF PLATINUM(II/IV) COMPLEXES WITH 2-AMINO-5-METHYL-4-PHENYLTHIAZOLE

2021 ◽  
Author(s):  
Danijela Lj. Stojković ◽  
◽  
Verica V. Jevtić ◽  
Đorđe S. Petrović ◽  
Sandra S. Jovičić Milić ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
General Formula ◽  
13C Nmr ◽  
13C Nmr Spectroscopy ◽  
Synthesis And Characterization ◽  
1H And 13C Nmr ◽  
Elemental Microanalysis

This paper examines the synthesis of two new complexes of platinum(II/IV) ion, general formula [PtL2]Cl2 and [PtL2]Cl4, where L is 2-amino-5-methyl-4-phenylthiazole. The structures of the above mentioned compounds were determined by elemental microanalysis, infrared, 1H and 13C NMR spectroscopy.

Synthesıs and Characterızatıon of New Trıazole and Coumarın-Derived Heterocyclıc Compounds Part I

2019 ◽  
Vol 41 (6) ◽  
pp. 1097-1097
Author(s):  
Nurhan G mr k o lu Nurhan G mr k o lu ◽  
Muhammad Imran and Inam Iqbal Muhammad Imran and Inam Iqbal
Keyword(s):  
Acetic Acid ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Heterocyclic Compounds ◽  
Acid Hydrazide ◽  
Triazole Ring ◽  
Basic Medium ◽  
Synthesis And Characterization ◽  
Ethyl Bromoacetate

Synthesis of ethyl ester of acetic acid containing 5-oxo-[1,2,4] triazole ring (2) was achieved by the condensation of 3-substituted-4-amino-1H-1,2,4-triazol-5(4H)-one (1) with ethyl bromoacetate in basic medium. Compound 2, was then further reacted with hydrazine hydrate to form acid hydrazide, which is 2-(4-amino-3-substituted-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)acetohydrazide (3). Compound 3 was later treated with three different diverse coumarin aldehydes (6, 12, 18) resulted in the formation of arylidene hydrazides as cis–trans conformers (7, 8, 13, 14, 19, 20). In conclusion, we synthesized 1,2,4-triazole Schiff bases derived from the condensation of 3-substituted-4-amino-1,2,4-triazole-5-on and formylhydroxy-4-methylcoumarin derivatives, which have been characterized by, spectroscopic measurements (IR, 1H-NMR, 13C-NMR and elemental analysis).

Synthesis and Characterization of Some New Esters Containing Heterocyclic and Derived From Azo Dyes

2019 ◽  
Vol 9 (02) ◽  
Author(s):  
Zena G. Alrecabi ◽  
Zainab Amer ◽  
Naeemah Al-Lami
Keyword(s):  
Schiff Base ◽  
13C Nmr ◽  
Azo Dyes ◽  
Spectral Methods ◽  
Anthranilic Acid ◽  
Heterocyclic Compounds ◽  
Synthesis And Characterization ◽  
Cooh Group ◽  
Molecular Weights

This study including prepared new colored esters containing heterocyclic with high molecular weights. In the first part of work we synthesized azo dyes [1,2] from the reaction p-toluidine with β-naphthol and o-nitro phenol, thin we synthesized Schiff bases [3,4] by the reaction anthranilic acid with benzaldehyde and dimethyl benzaldehyde. The reaction azo dyes (contain OH group) with Schiff base (contain COOH group) these led to produce the new colored esters [A1-A4]. The second part of work was modification the (C=N-) group in esters to heterocyclic compounds by reacting with phenyl iso cyanide to produce new β-lactam [B1-B4] and with anthranilic acid to get new hydroquinazoline [C1-C4]. All these compounds were characterized by physical properties and spectral methods FTIR, 1H-NMR and 13C-NMR.

8-Acyl-7-phenylbicyclo[2.2.2]-2,6-diones by rearrangement of 3-acyloxy-5-(2-phenylethenyl)-2-cyclohexen-1-ones. 1H and 13C NMR spectral evidence of their structure

1990 ◽  
Vol 55 (5) ◽  
pp. 1208-1215 ◽  
Author(s):  
Pavel Hrnčiar ◽  
Tibor Liptay ◽  
Ján Šraga
Keyword(s):  
Double Bond ◽  
Spectral Data ◽  
13C Nmr ◽  
1H And 13C Nmr ◽  
Spectral Evidence ◽  
C Nmr

3-Acyloxy-5-(2-phenylethenyl)-2-cyclohexen-1-ones II were prepared by O-acylation of 5-(2-phenylethenyl)-1,3-cycloxanedione (I). Treatment of II with AlCl3 resulted in rearrangement of the acyl group to the double bond of the phenylethenyl grouping followed by cyclization to 8-acyl-7-phenylbicyclo[2.2.2]octane-2,6-diones III. Their structure was evidenced by analysis of the 1H and 13C NMR spectral data.

Synthesis and Characterization of N-butyl-N-methylimidazolium- D-(-)-tartrate Chiral Ionic Liquid

2012 ◽  
Vol 518-523 ◽  
pp. 3989-3992 ◽  
Author(s):  
Yang Zhang ◽  
Xiao Hua Tu ◽  
Cheng Ping Miao ◽  
Jian Yi Wu
Keyword(s):  
Ionic Liquid ◽  
1H Nmr ◽  
Ion Chromatography ◽  
13C Nmr ◽  
Nmr Spectra ◽  
Optical Rotation ◽  
Synthesis And Characterization ◽  
13C Nmr Spectra ◽  
Chiral Ionic Liquid

A novel CIL of N-butyl-N-methyl imidazolium-D-(-)-tartrate has been designed and synthesized by neutralization reaction. Its structure was characterized by 1H-NMR and 13C-NMR spectra, the optical rotation was characterized by polarimeter with the value of-15.0º, and the purity was characterized by ion chromatography with the value of 98.4%.

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