SYNTHESIS AND CHARACTERIZATION OF PLATINUM(II/IV) COMPLEXES WITH 2-AMINO-5-METHYL-4-PHENYLTHIAZOLE

This paper examines the synthesis of two new complexes of platinum(II/IV) ion, general formula [PtL2]Cl2 and [PtL2]Cl4, where L is 2-amino-5-methyl-4-phenylthiazole. The structures of the above mentioned compounds were determined by elemental microanalysis, infrared, 1H and 13C NMR spectroscopy.

Synthesis and spectral studies of some metal complexes derived from 1,3,4-oxadiazole and Evaluated of biological activity

In this study we reports the preparation and characterization of ligand [L1] [2,5-bis(4-butoxy phenyl) -1,3,4- oxadiazole in four steps. First from (4-hydroxy benzoic acid) treated with solution of potassium hydroxide and normal bromo alkane (RBr) R=[(CH3(CH2)3] to prepared precursor [ H1] 4-( butyloxy) benzoic acid. The second step have been prepared the precursor [H2]4-( butyloxy) benzoate from compound [H1] in methanolic acidic solution with drops of H2SO4 . The third step prepared the precursor [H3] 4-(n-butoxy) benzo hydrazide by the reaction [H2] and hydrazine hydrate(90%). The last step reaction between precursor [H1] and [H3] in present of POCls to obtained ligand [L1]. The primary ligand [L1] was characterized by Fourier transform infrared spectraFT-IR,1H-NMR,13C-NMR,Termal Gravimetric analysis (UV-Vis) spectrophotometer, Mass spectroscopy and elemental microanalysis (C-H-N) and melting point .The secondary ligand benzyl (propane-2-yl) carbamodithioate (S-bpth) was prepared according to the litreture (13). The Ag(L1) complex was prepared from 2 mole of L1 and one mole of AgNO3 in CH2Cl2 solvent at inert condition. The complexes Ni(II), Pd(II), Pt(II), Cu(II) and Zn(II) were synthesized from the two mole of primary ligand(L1 ) and one mole secondary ligand (S-bpth) with one m mole of metal chloride in ethanol medium and characterized comprehensively by Fourier transform infrared spectra(FT-IR), (UV-Vis) spectrophotometer, elemental microanalysis (C.H.N) metal analysis, Atomic absorption spectrophotometer

An Efficient and Mild Method for the Synthesis and Hydrazinolysis ofN-Glyoxylamino Acid Esters

N-Glyoxylamino acid ester derivatives were synthesized via the ring opening ofN-acetylisatin using moderate conditions. During the hydrazinolysis ofN-glyoxylamino acid ester derivatives with hydrazine hydrate (80%) in methanol, unexpected reduction of theα-keto group occurred to affordN-acylamino acid hydrazide derivatives in good yield (80–90%) (Wolff-Kishner type reaction). All the synthesized compounds were characterized by1H NMR,13C NMR, and elemental microanalysis.