scholarly journals Analysis of CD4+ T cells in HIV-1 infection model combined with RTI and PI treatments

2020 ◽  
Vol 16 (2) ◽  
pp. 218-222
Author(s):  
Sutimin Sutimin ◽  
R. Heru Tjahjana ◽  
Sunarsih Sunarsih
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Hiv Transmission ◽  
Transcriptase Inhibitor ◽  
Infection Process ◽  
Infection Model ◽  
The Stability ◽  
Immunodeficiency Syndrome ◽  
Reverse Transcriptase Inhibitor ◽  
Hiv 1

HIV (Human Immunodeficiency Virus) is a retrovirus that attacks the immune system and subsequently leading to AIDS (Acquired Immunodeficiency Syndrome). CD4+ T cells are among the immune systems destroyed by HIV. The HIV transmission from cell to cell is an infection process of spreading HIV-1 infection. The study developed a mathematical model by considering the contact between HIV-1-infected CD4+ T cells and healthy CD4+ T cells, incorporating antiretroviral treatment. The stability of equilibriums for the model was studied. The local stability for disease-free equilibrium and the global stability for endemic equilibrium were studied. Numerical simulations were presented to examine the implication of antiretroviral therapy. Simulation results showed that reverse transcriptase inhibitor (RTI) therapy was more effective compared to protease inhibitor (PI) therapy in increasing the number of healthy CD4+ T cells.

Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells

10.1038/nm880 ◽  
2003 ◽  
Vol 9 (6) ◽  
pp. 727-728 ◽  
Author(s):  
Janet D Siliciano ◽  
Joleen Kajdas ◽  
Diana Finzi ◽  
Thomas C Quinn ◽  
Karen Chadwick ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Latent Reservoir ◽  
Follow Up Studies ◽  
Long Term Follow Up ◽  
The Stability ◽  
Hiv 1

An in-host HIV-1 infection model incorporating quiescent and activated CD4+ T cells as well as CTL response

2021 ◽  
Vol 409 ◽  
pp. 126410
Author(s):  
Sutimin ◽  
Karunia Putra Wijaya ◽  
Joseph Páez Chávez ◽  
Tianhai Tian
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Infection Model ◽  
Ctl Response ◽  
Hiv 1

scholarly journals Mode of Transmission Affects the Sensitivity of Human Immunodeficiency Virus Type 1 to Restriction by Rhesus TRIM5α

2008 ◽  
Vol 82 (22) ◽  
pp. 11117-11128 ◽  
Author(s):  
Max W. Richardson ◽  
Richard G. Carroll ◽  
Matthew Stremlau ◽  
Nikolay Korokhov ◽  
Laurent M. Humeau ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cells ◽  
Cd4 T Cells ◽  
Hiv Transmission ◽  
Human Cells ◽  
Cell Contact ◽  
Hiv Therapy ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT Rhesus TRIM5α (rhTRIM5α), but not human TRIM5α (huTRIM5α), potently inhibits human immunodeficiency virus (HIV) infection and is thus a potentially valuable therapeutic tool. Primary human CD4 T cells engineered to express rhTRIM5α were highly resistant to cell-free HIV type 1 (HIV-1) infection. However, when cocultured with unmodified T cells, rhTRIM5α-expressing cells became highly permissive to HIV-1 infection. Physical separation of rhTRIM5α-expressing cells and unmodified cells revealed that rhTRIM5α efficiently restricts cell-free but not cell-associated HIV transmission. Furthermore, we observed that HIV-infected human cells could infect rhesus CD4 T cells by cell-to-cell contact, but the infection was self-limiting. Subsequently, we noted that a spreading infection ensued when HIV-1-infected rhTRIM5α-expressing human cells were cultured with huTRIM5α- but not rhTRIM5α-expressing cells. Our results suggest that cell-associated HIV transmission in humans is blocked only when both donor and recipient cells express rhTRIM5α. These studies further define the role of rhTRIM5α in cell-free and cell-associated HIV transmission and delineate the utility of rhTRIM5α in anti-HIV therapy.

scholarly journals Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1

2007 ◽  
Vol 204 (4) ◽  
pp. 705-714 ◽  
Author(s):  
Zhifeng Sun ◽  
Paul W. Denton ◽  
Jacob D. Estes ◽  
Florence A. Othieno ◽  
Bangdong L. Wei ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Lymphoid Tissue ◽  
Hiv Transmission ◽  
Human Lymphocytes ◽  
Systemic Infection ◽  
Developed Countries ◽  
Humanized Mice ◽  
Hematopoietic Stem ◽  
Hiv 1

Intrarectal infection between men who have sex with men represents a predominant form of human immunodeficiency virus (HIV) transmission in developed countries. Currently there are no adequate small animal models that recapitulate intrarectal HIV transmission. Here we demonstrate that human lymphocytes generated in situ from hematopoietic stem cells reconstitute the gastrointestinal tract of humanized mice with human CD4+ T cells rendering them susceptible to intrarectal HIV transmission. HIV infection after a single intrarectal inoculation results in systemic infection with depletion of CD4+ T cells in gut-associated lymphoid tissue and other pathologic sequela that closely mimics those observed in HIV infected humans. This novel model provides the basis for the development and evaluation of novel approaches aimed at immune reconstitution of human gut-associated lymphoid tissue and for the development, testing, and implementation of microbicides to prevent intrarectal HIV-1 transmission.

Sign in / Sign up

Export Citation Format

Share Document