The effect of insulin therapy algorithms on blood glucose levels in patients following cardiac surgery: a systematic review

O trabalho tem como objetivo analisar os estudos que avaliaram os efeitos dos programas de treinamento aeróbio, força e combinado nos níveis de glicose sanguínea em indivíduos com diabetes do tipo 2. Foi utilizado o método de revisão sistemática, sendo utilizada a base de dados PubMed. As palavras chaves utilizadas para pesquisa foram training and diabetes. Foram identificados 484 artigos originais. Apenas 17 estudos respeitaram os critérios de inclusão. Os resultados evidenciam que os programas de treinamento aeróbio diminuíram os níveis de glicose. O programa de treinamento de força também foi favorável à diminuição dos níveis de glicose sanguínea. Já o programa de treinamento combinado não demonstrou efeitos favoráveis no controle da glicose sanguínea. Conclui-se que o programa de treinamento aeróbio e de força ajudam a controlar os níveis de glicose sanguínea em indivíduos com diabetes do tipo 2. Palavras-chave: diabetes mellitus, treinamento, glicose.ABSTRACTThe study aims to analyze the studies that evaluated the effects of aerobic, strength and combined programs training in blood glucose levels in people with type 2 diabetes. We used a systematic review method and is used to PubMed database. The key words used for searching were training and diabetes. We identified 484 original articles. Only 17 studies complied with the inclusion criteria. The results show that aerobic training programs decreased glucose levels. The strength training program was also favorable to decrease in blood glucose levels. But the combined training program has not shown favorable effects on blood glucose control. We conclude that the aerobic training and strength helps control blood glucose levels in individuals with type 2 diabetes. Keywords: diabetes mellitus, training, glucose.

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Self-monitoring of Blood Glucose Levels and Intensified Insulin Therapy

JAMA ◽

10.1001/jama.1983.03330450043023 ◽

1983 ◽

Vol 249 (21) ◽

pp. 2913 ◽

Cited By ~ 6

Author(s):

Mitchell E. Geffner

Keyword(s):

Blood Glucose ◽

Insulin Therapy ◽

Self Monitoring ◽

Glucose Levels ◽

Intensified Insulin Therapy ◽

Blood Glucose Levels

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Intensive Insulin Therapy and Pentastarch Resuscitation in Sepsis

50 Studies Every Anesthesiologist Should Know ◽

10.1093/med/9780190237691.003.0021 ◽

2018 ◽

pp. 109-113

Keyword(s):

Septic Shock ◽

Severe Sepsis ◽

Blood Glucose ◽

Insulin Therapy ◽

Fluid Resuscitation ◽

Intensive Insulin Therapy ◽

Safety And Efficacy ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Ringer’S Lactate

This case focuses on the use of intensive insulin therapy with sepsis by asking the question: What are the safety and efficacy of intensive insulin therapy compared with conventional therapy and hydroxyethyl starch (HES) compared with Ringer’s lactate in patients with severe sepsis or septic shock? This study demonstrated that critically ill patients did not benefit from intensive insulin therapy targeting blood glucose levels of 80–110 mg/dL vs. conventional insulin therapy nor from fluid resuscitation with HES vs. Ringer’s lactate. Neither intensive insulin therapy nor fluid resuscitation with HES is currently recommended in major sepsis guidelines.

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Transient bilateral diabetic cataracts in a Brazilian Terrier puppy

Ciência Rural ◽

10.1590/s0103-84782005000300036 ◽

2005 ◽

Vol 35 (3) ◽

pp. 709-712

Author(s):

Carla de Freitas Campos ◽

Lilian Stefanoni Ferreira ◽

Marlos Gonçalves Sousa ◽

Fernanda Gomes Velasque Gama ◽

José Luiz Laus ◽

...

Keyword(s):

Blood Glucose ◽

Glycemic Control ◽

Insulin Therapy ◽

Lens Opacity ◽

Human Beings ◽

Glucose Levels ◽

Blood Glucose Levels ◽

And Control

A case of a Brazilian Terrier puppy presenting diabetic lens opacity that restored transparency after insulin therapy and control of blood glucose levels is reported. This entity has been rarely reported in human beings and has not been reported in dogs before. The rapid glycemic control may have been responsible for the transparency recovery.

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Leptin contributes to the beneficial effects of insulin treatment in streptozotocin-diabetic male mice

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.00159.2018 ◽

2018 ◽

Vol 315 (6) ◽

pp. E1264-E1273

Author(s):

Ursula H. Neumann ◽

Michelle M. Kwon ◽

Robert K. Baker ◽

Timothy J. Kieffer

Keyword(s):

Blood Glucose ◽

Insulin Therapy ◽

Daily Injection ◽

Diabetic Mice ◽

Glucose Lowering ◽

Beneficial Effects ◽

Glucose Levels ◽

Lowering Effect ◽

Blood Glucose Levels ◽

Glucose Lowering Effect

It was long thought that the only hormone capable of reversing the catabolic consequences of diabetes was insulin. However, various studies have demonstrated that the adipocyte-derived hormone leptin can robustly lower blood glucose levels in rodent models of insulin-deficient diabetes. In addition, it has been suggested that some of the metabolic manifestations of insulin-deficient diabetes are due to hypoleptinemia as opposed to hypoinsulinemia. Because insulin therapy increases leptin levels, we sought to investigate the contribution of leptin to the beneficial effects of insulin therapy. To do this, we tested insulin therapy in streptozotocin (STZ) diabetic mice that were either on an ob/ ob background or that were given a leptin antagonist to determine if blocking leptin action would blunt the glucose-lowering effects of insulin therapy. We found that STZ diabetic ob/ ob mice have a diminished blood glucose-lowering effect in response to insulin therapy compared with STZ diabetic controls and exhibited more severe weight loss post-STZ injection. In addition, STZ diabetic mice administered a leptin antagonist through daily injection or plasmid expression respond less robustly to insulin therapy as assessed by both fasting blood glucose levels and blood glucose levels during an oral glucose tolerance test. However, leptin antagonism did not prevent the insulin-induced reduction in β-hydroxybutyrate and triglyceride levels. Therefore, we conclude that elevated leptin levels can contribute to the glucose-lowering effect of insulin therapy in insulin-deficient diabetes.

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