scholarly journals Effects of different routes of nicotine administration on gastric morphology and hormonal secretion in rats

2015 ◽  
Vol 100 (8) ◽  
pp. 881-895 ◽  
Author(s):  
Soad Shaker Ali ◽  
Enas Ahmed Hamed ◽  
Nasra Naeim Ayuob ◽  
Ahmed Shaker Ali ◽  
Mansour Ibrahem Suliman

1962 ◽  
Vol 41 (4) ◽  
pp. 584-594 ◽  
Author(s):  
Dankwart Reinwein ◽  
Erich Klein

ABSTRACT The iodine metabolism was investigated in 29 patients with euthyroid non-endemic diffuse goiter. 1 to 14 days before thyroidectomy the patients received carrier-free 131I. The chemical iodine fractions (PBI, BEI and iodide) of the thyroid and the labelled iodine compound were analyzed by means of paper- and column chromatography. In one gland the total iodine content varied only by ± 19.6% of the average, the relative shares of PBI, BEI and iodide as well as that of the iodoamino acids being equal. Monoiodotyrosine, diiodotyrosine and thyroxine were found in the thyroid homogenate without hydrolysis. The homogenate after hydrolysis contained more iodotyrosines at the expense of iodothyronines than do normal glands. 17 goiters with normal 131I-uptake showed a high total iodine content (14.2 ± 5.0 mg) whilst 9 goiters with an increased 131I-uptake had low values (3.58 ± 0.6 mg). The opposite was found for the relative shares of BEI with the chromatographically isolated iodothyronines thyroxine, triiodothyronine and an unidentified iodine compound. Goiters with »high plasma PB131I« were characterized by a faster transfer of 131I into the more heavily iodinated compounds than is found in glands with a normal hormonal secretion rate. The highest values for the iodothyronines were found in goiters with increased 131I-uptake together with a high hormonal secretion rate. From this study it appears that the changes in the iodine-poor glands are due to a defective exo- or endogenous iodine supply. The observed alterations in iodine-rich glands are probably induced by a faulty iodine utilization characterized by an incomplete iodotyrosyl-coupling defect.



2018 ◽  
Author(s):  
Carmen Gabriela Barbu ◽  
Adrian Teodor Pienary ◽  
Alice Albu ◽  
Sorina Martin ◽  
Anca Sirbu ◽  
...  


2014 ◽  
Vol 6 (3) ◽  
pp. 191-200 ◽  
Author(s):  
Patricia Mesa-Gresa ◽  
Marta Ramos-Campos ◽  
Rosa Redolat






Life Sciences ◽  
1987 ◽  
Vol 40 (17) ◽  
pp. 1699-1708 ◽  
Author(s):  
L.Charles Murrin ◽  
James R. Ferrer ◽  
Zeng Wanyun ◽  
Nancy J. Haley


2004 ◽  
Vol 56 (3) ◽  
pp. 359-366 ◽  
Author(s):  
Göksel Sener ◽  
Caner Kapucu ◽  
Kübra Paskaloglu ◽  
Gül Ayanoglu-Dülger ◽  
Serap Arbak ◽  
...  


2011 ◽  
Vol 18 (6) ◽  
pp. R197-R211 ◽  
Author(s):  
Odelia Cooper ◽  
George Vlotides ◽  
Hidenori Fukuoka ◽  
Mark I Greene ◽  
Shlomo Melmed

The role of ErbB family in discreet pituitary functions is reviewed. Several ErbB receptor ligands, EGF, TGFα, and heregulin are differentially expressed in normal gonadotroph and lacto-somatotroph lineages, and other elements of the anterior pituitary. ErbB receptors, i.e. EGFR and ErbB2, are also localized to the anterior pituitary with preferential EGFR lactosomatotroph expression. EGF regulates CRH and ACTH secretion and corticotroph proliferation as well as exhibiting autocrine and paracrine effects on gonadotrophs and on lactosomatotroph proliferation, gene and protein expression, and hormonal secretion. EGF and EGFR are expressed in both functioning and non-functioning pituitary adenomas, with higher expression in more aggressive tumor subtypes. ErbB2 receptor is detected in all tumor subtypes, particularly in invasive tumors. ErbB tyrosine kinase inhibitors regulate hormonal secretion, cell morphology, and proliferation in lacto-somatotroph tumors, reflecting the emerging application of targeted pituitary therapeutics.



2009 ◽  
Vol 24 (11) ◽  
pp. 1709-1715 ◽  
Author(s):  
EL Mullings ◽  
LF Donaldson ◽  
JK Melichar ◽  
MR Munafò


2000 ◽  
Vol 867 (1-2) ◽  
pp. 157-164 ◽  
Author(s):  
Ming D Li ◽  
Justin K Kane ◽  
Steven L Parker ◽  
Kathy McAllen ◽  
Shannon G Matta ◽  
...  


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