scholarly journals Basal forebrain GABAergic innervation of olfactory bulb periglomerular interneurons

2019 ◽  
Vol 597 (9) ◽  
pp. 2547-2563 ◽  
Author(s):  
Alvaro Sanz Diez ◽  
Marion Najac ◽  
Didier Saint Jan
Keyword(s):  
Olfactory Bulb ◽  
Basal Forebrain ◽  
Gabaergic Innervation

scholarly journals GABAergic Input From the Basal Forebrain Promotes the Survival of Adult-Born Neurons in the Mouse Olfactory Bulb

2020 ◽  
Vol 14 ◽  
Author(s):  
Elizabeth Hanson ◽  
Jessica Swanson ◽  
Benjamin R. Arenkiel
Keyword(s):  
Olfactory Bulb ◽  
Basal Forebrain ◽  
Adult Born Neurons

Presynaptic Muscarinic Receptors Enhance Glutamate Release at the Mitral/Tufted to Granule Cell Dendrodendritic Synapse in the Rat Main Olfactory Bulb

2009 ◽  
Vol 101 (4) ◽  
pp. 2052-2061 ◽  
Author(s):  
Ambarish S. Ghatpande ◽  
Alan Gelperin
Keyword(s):  
Olfactory Bulb ◽  
Granule Cell ◽  
Basal Forebrain ◽  
Granule Cells ◽  
Calcium Influx ◽  
Glutamate Release ◽  
Gaba Release ◽  
Cellular Mechanisms ◽  
Tufted Cells

The mammalian olfactory bulb receives multiple modulatory inputs, including a cholinergic input from the basal forebrain. Understanding the functional roles played by the cholinergic input requires an understanding of the cellular mechanisms it modulates. In an in vitro olfactory bulb slice preparation we demonstrate cholinergic muscarinic modulation of glutamate release onto granule cells that results in γ-aminobutyric acid (GABA) release onto mitral/tufted cells. We demonstrate that the broad-spectrum cholinergic agonist carbachol triggers glutamate release from mitral/tufted cells that activates both AMPA and NMDA receptors on granule cells. Activation of the granule cell glutamate receptors leads to calcium influx through voltage-gated calcium channels, resulting in spike-independent, asynchronous GABA release at reciprocal dendrodendritic synapses that granule cells form with mitral/tufted cells. This cholinergic modulation of glutamate release persists through much of postnatal bulbar development, suggesting a functional role for cholinergic inputs from the basal forebrain in bulbar processing of olfactory inputs and possibly in postnatal development of the olfactory bulb.

scholarly journals Cholinergic Inputs from Basal Forebrain Add an Excitatory Bias to Odor Coding in the Olfactory Bulb

2014 ◽  
Vol 34 (13) ◽  
pp. 4654-4664 ◽  
Author(s):  
M. Rothermel ◽  
R. M. Carey ◽  
A. Puche ◽  
M. T. Shipley ◽  
M. Wachowiak
Keyword(s):  
Olfactory Bulb ◽  
Basal Forebrain ◽  
Odor Coding

Neuronal loss and GABAergic innervation in the basal forebrain

1988 ◽  
Vol 11 (5) ◽  
pp. 209 ◽  
Author(s):  
Norbert Ulfig
Keyword(s):  
Basal Forebrain ◽  
Neuronal Loss ◽  
Gabaergic Innervation

Soluble proteins from rat olfactory bulb promote the survival and differentiation of cultured basal forebrain neurons

1988 ◽  
Vol 41 (1-2) ◽  
pp. 263-276 ◽  
Author(s):  
Mary P. Lambert ◽  
Thomas Megerian ◽  
Gwenn Garden ◽  
William L. Klein
Keyword(s):  
Olfactory Bulb ◽  
Basal Forebrain ◽  
Soluble Proteins ◽  
Forebrain Neurons

Cholinergic divergent projections from rat basal forebrain to the hippocampus and olfactory bulb

1987 ◽  
Vol 83 (1-2) ◽  
pp. 77-81 ◽  
Author(s):  
S. Okoyama ◽  
H. Tago ◽  
P.L. McGeer ◽  
L.B. Hersh ◽  
H. Kimura
Keyword(s):  
Olfactory Bulb ◽  
Basal Forebrain

scholarly journals The diagonal band of broca continually regulates olfactory-mediated behaviors by modulating odor-evoked responses within the olfactory bulb

2020 ◽  
Author(s):  
Inna Schwarz ◽  
Monika Müller ◽  
Irina Pavlova ◽  
Jens Schweihoff ◽  
Fabrizio Musacchio ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Basal Forebrain ◽  
Behavioral Responses ◽  
Brain Regions ◽  
Evoked Responses ◽  
Response Modulation ◽  
Top Down ◽  
Diagonal Band ◽  
Diagonal Band Of Broca ◽  
Interneuron Activity

AbstractSensory perception is modulated in a top-down fashion by higher brain regions to regulate the strength of its own input resulting in the adaptation of behavioral responses. In olfactory perception, the horizontal diagonal band of broca (HDB), embedded in the basal forebrain modulates olfactory information processing by recruiting olfactory bulb (OB) interneuron activity to shape excitatory OB output. Currently, little is known about how specific HDB to OB top down signaling affects complex olfactory-mediated behaviors. Here we show that the olfactory bulb is strongly and differentially innervated by HDB projections. HDB-silencing via tetanus toxin lead to reduced odor-evoked Ca2+-responses in glomeruli of the main OB, underscoring the HDB’s role in odor response modulation. Furthermore, selective, light-mediated silencing of only HDB to OB afferents completely prevented olfactory-mediated habituation and discrimination behaviors. Notably, also social habituation and discrimination behaviors were affected. Here we provide evidence for a novel tri-synaptic paraventricular nucleus (PVN)-HDB-OB axis responsible for modulating these types of behavior. Thus, HDB to OB projections constitute a central top-down pathway for olfactory-mediated habituation and discrimination.

scholarly journals Input dependent modulation of olfactory bulb activity by GABAergic basal forebrain projections

2020 ◽  
Author(s):  
Erik Böhm ◽  
Daniela Brunert ◽  
Markus Rothermel
Keyword(s):  
Olfactory Bulb ◽  
Sensory Processing ◽  
Basal Forebrain ◽  
Sensory Input ◽  
Sensory Information ◽  
Neuron Activity ◽  
Differential Modulation ◽  
Cholinergic Basal Forebrain ◽  
The Brain ◽  
Cholinergic Projections

AbstractBasal forebrain modulation of central circuits is associated with active sensation, attention and learning. While cholinergic modulations have been studied extensively the effect of non-cholinergic basal forebrain subpopulations on sensory processing remains largely unclear. Here, we directly compare optogenetic manipulation effects of two major basal forebrain subpopulations on principal neuron activity in an early sensory processing area, i.e. mitral/tufted cells (MTCs) in the olfactory bulb. In contrast to cholinergic projections, which consistently increased MTC firing, activation of GABAergic fibers from basal forebrain to the olfactory bulb lead to differential modulation effects: while spontaneous MTC activity is mainly inhibited, odor evoked firing is predominantly enhanced. Moreover, sniff triggered averages revealed an enhancement of maximal sniff evoked firing amplitude and an inhibition of firing rates outside the maximal sniff phase. These findings demonstrate that GABAergic neuromodulation affects MTC firing in a bimodal, sensory-input dependent way, suggesting that GABAergic basal forebrain modulation could be an important factor in attention mediated filtering of sensory information to the brain.

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