The significance of the loss of presynaptic inhibition for step initiation in parkinsonian individuals with freezing of gait

2021 ◽  
Author(s):  
Halil Onder ◽  
Bilge Kocer ◽  
Selcuk Comoglu
Keyword(s):  
Presynaptic Inhibition ◽  
Freezing Of Gait ◽  
Step Initiation

The significance of the loss of presynaptic inhibition for step initiation in parkinsonian individuals with freezing of gait?

2021 ◽  
Author(s):  
Jumes Leopoldino Oliveira Lira ◽  
Carlos Ugrinowitsch ◽  
Daniel Boari Coelho ◽  
Luis Augusto Teixeira ◽  
Andrea Cristina Lima‐Pardini ◽  
...  
Keyword(s):  
Presynaptic Inhibition ◽  
Freezing Of Gait ◽  
Step Initiation

scholarly journals Loss of presynaptic inhibition for step initiation in parkinsonian individuals with freezing of gait

2020 ◽  
Vol 598 (8) ◽  
pp. 1611-1624 ◽  
Author(s):  
Jumes Leopoldino Oliveira Lira ◽  
Carlos Ugrinowitsch ◽  
Daniel Boari Coelho ◽  
Luis Augusto Teixeira ◽  
Andrea Cristina Lima‐Pardini ◽  
...  
Keyword(s):  
Presynaptic Inhibition ◽  
Freezing Of Gait ◽  
Step Initiation

scholarly journals ‘Recoupling’ the attentional and motor control of preparatory postural adjustments to overcome Freezing of Gait in Parkinson’s

2020 ◽  
Author(s):  
Amy Maslivec ◽  
Anna Fielding ◽  
Mark Wilson ◽  
Meriel Norris ◽  
William Young
Keyword(s):  
Motor Control ◽  
Cognitive Deficits ◽  
Critical Evaluation ◽  
Freezing Of Gait ◽  
Baseline Condition ◽  
Verbal Instruction ◽  
Step Initiation ◽  
Weight Shift ◽  
Pronounced Reduction ◽  
Weight Shifting

Abstract Objectives: This study examined if people with Parkinson’s and freezing of gait pathology (FoG) could be trained to increase preparatory weight-shift amplitude, and facilitate step initiation during FoG. Methods: Thirty-five people with Parkinson’s and FoG attempted to initiate forward walking from a stationary position caused by a freeze (n=17, FoG-F) or voluntarily stop (n=18, FoG-NF) in a Baseline condition and two conditions where an increased weight-shift amplitude was trained via: i) explicit verbal instruction, and ii) implicit movement analogies. Results: At Baseline, weight-shift amplitudes were smaller during: i) unsuccessful, compared to successful step initiations (FoG-F group), and ii) successful step initiations in the FoG-F group compared to FoG-NF. Both Verbal and Analogy training resulted in significant increases in weight-shift amplitude in both groups, and a corresponding pronounced reduction in unsuccessful attempts to initiate stepping (FoG-F group). Conclusions: Hypometric preparatory weight-shifting is associated with failure to initiate forward stepping in people with Parkinson’s and FoG. However, impaired weight-shift characteristics are modifiable through conscious strategies. This current study provides a novel and critical evaluation of preparatory weight-shift amplitudes during FoG events. The intervention described represents an attractive ‘rescue’ strategy and should be further scrutinised regarding limitations posed by physical and cognitive deficits.

scholarly journals The Therapeutic Effect of Nordic Walking on Freezing of Gait in Parkinson’s Disease: A Pilot Study

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Agata Wróblewska ◽  
Agata Gajos ◽  
Urszula Smyczyńska ◽  
Andrzej Bogucki
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Research Question ◽  
Freezing Of Gait ◽  
Intervention Group ◽  
Future Research ◽  
Control Group ◽  
Nordic Walking ◽  
Provocative Test ◽  
Step Initiation

Introduction. The effectiveness of the currently utilized therapies for FoG is limited. Several studies demonstrated a beneficial impact of Nordic walking (NW) on several gait parameters in Parkinson’s disease, but only one paper reported reduction of freezing. Research Question. In the present study, the question is whether NW is an effective therapeutic intervention in FoG. Methods. Twenty PD subjects trained NW for 12 weeks, with a frequency of twice per week. Each session lasted about 60 minutes. Twenty patients in the control group did not use any form of physiotherapy (no-intervention group). Freezing of Gait Questionnaire (FOGQ), the Timed Up and Go (TUG) test, and the Provocative Test for Freezing and Motor Blocks (PTFMB) were performed at baseline, immediately after the end of NW program, and three months later. Results. The results of FOGQ, TUG, and total PTFMB revealed significant improvement after completing the exercise program, and this effect persisted at follow-up. The results of the PTFMB subtests showed a different effect of NW on particular subtypes of FoG. Start hesitation, sudden transient blocks that interrupt gait, and blocks on turning improved considerably, while motor blocks, when walking through narrow space and on reaching the target, did not respond to NW training. Significance. The results show, for the first time, that FoG during turning and step initiation, two most common forms of this gait disorder, has been significantly reduced by NW training. Different responses of particular subtypes of FoG to NW probably reflect their different pathophysiologies. Conclusions. The present study showed that NW training had a beneficial effect on FOG in PD and that the achieved improvement is long-lasting. Future research should clarify whether the observed improvement limited to FoG triggered by only some circumstances reflects different pathomechanisms of FoG subtypes.

scholarly journals ‘Recoupling’ the attentional and motor control of preparatory postural adjustments to overcome Freezing of Gait in Parkinson’s

2020 ◽  
Author(s):  
Amy Maslivec ◽  
Anna Fielding ◽  
Mark Wilson ◽  
Meriel Norris ◽  
William Young
Keyword(s):  
Motor Control ◽  
Cognitive Deficits ◽  
Critical Evaluation ◽  
Freezing Of Gait ◽  
Baseline Condition ◽  
Verbal Instruction ◽  
Step Initiation ◽  
Weight Shift ◽  
Pronounced Reduction ◽  
Weight Shifting

Abstract Objectives This study examined if people with Parkinson’s and freezing of gait pathology (FoG) could be trained to increase preparatory weight-shift amplitude, and facilitate step initiation during FoG. Methods Thirty-five people with Parkinson’s and FoG attempted to initiate forward stepping either during a FoG event (n = 17, FoG-F) or following a voluntary stop (n = 18, FoG-NF) in a Baseline condition and two conditions where an increased weight-shift amplitude was trained via: i) Explicit verbal instruction, and ii) Implicit movement analogies. Results At Baseline, weight-shift amplitudes were smaller during: i) unsuccessful, compared to successful step initiations (FoG-F group), and ii) successful step initiations in the FoG-F group compared to FoG-NF. Both Verbal and Analogy training resulted in significant increases in weight-shift amplitude in both groups, and a corresponding pronounced reduction in unsuccessful attempts to initiate stepping (FoG-F group). Conclusions Hypometric preparatory weight-shifting is associated with failure to initiate forward stepping in people with Parkinson’s and FoG. However, impaired weight-shift characteristics are modifiable through conscious strategies. This current study provides a novel and critical evaluation of preparatory weight-shift amplitudes during FoG events. The intervention described represents an attractive ‘rescue’ strategy and should be further scrutinised regarding limitations posed by physical and cognitive deficits.

scholarly journals ‘Recoupling’ the attentional and motor control of preparatory postural adjustments to overcome Freezing of Gait in Parkinson’s

2020 ◽  
Author(s):  
Amy Maslivec ◽  
Anna Fielding ◽  
Mark Wilson ◽  
Meriel Norris ◽  
William Young
Keyword(s):  
Motor Control ◽  
Cognitive Deficits ◽  
Critical Evaluation ◽  
Freezing Of Gait ◽  
Verbal Instruction ◽  
Step Initiation ◽  
Weight Shift ◽  
Baseline Weight ◽  
Pronounced Reduction ◽  
Weight Shifting

Abstract Objectives This study examined if people with Parkinson’s and freezing of gait pathology (FoG) could be trained to increase preparatory weight-shift amplitude, and facilitate step initiation during FoG. Methods Thirty-five people with Parkinson’s and FoG attempted to initiate forward stepping either during a FoG event (n=17, FoG-F) or following a voluntary stop (n=18, FoG-NF) in a Baseline condition and two conditions where an increased weight-shift amplitude was trained via: i) Explicit verbal instruction, and ii) Implicit movement analogies. Results At Baseline , weight-shift amplitudes were smaller during: i) unsuccessful, compared to successful step initiations (FoG-F group), and ii) successful step initiations in the FoG-F group compared to FoG-NF. Both Verbal and Analogy training resulted in significant increases in weight-shift amplitude in both groups, and a corresponding pronounced reduction in unsuccessful attempts to initiate stepping (FoG-F group). Conclusions Hypometric preparatory weight-shifting is associated with failure to initiate forward stepping in people with Parkinson’s and FoG. However, impaired weight-shift characteristics are modifiable through conscious strategies. This current study provides a novel and critical evaluation of preparatory weight-shift amplitudes during FoG events. The intervention described represents an attractive ‘rescue’ strategy and should be further scrutinised regarding limitations posed by physical and cognitive deficits.

scholarly journals ‘Recoupling’ the attentional and motor control of preparatory postural adjustments to overcome freezing of gait in Parkinson’s

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Amy Maslivec ◽  
Anna Fielding ◽  
Mark Wilson ◽  
Meriel Norris ◽  
William Young
Keyword(s):  
Motor Control ◽  
Cognitive Deficits ◽  
Critical Evaluation ◽  
Freezing Of Gait ◽  
Baseline Condition ◽  
Verbal Instruction ◽  
Step Initiation ◽  
Weight Shift ◽  
Pronounced Reduction ◽  
Weight Shifting

Abstract Objectives This study examined if people with Parkinson’s and freezing of gait pathology (FoG) could be trained to increase preparatory weight-shift amplitude, and facilitate step initiation during FoG. Methods Thirty-five people with Parkinson’s and FoG attempted to initiate forward walking from a stationary position caused by a freeze (n = 17, FoG-F) or voluntarily stop (n = 18, FoG-NF) in a Baseline condition and two conditions where an increased weight-shift amplitude was trained via: (i) explicit verbal instruction, and (ii) implicit movement analogies. Results At Baseline, weight-shift amplitudes were smaller during: (i) unsuccessful, compared to successful step initiations (FoG-F group), and (ii) successful step initiations in the FoG-F group compared to FoG-NF. Both Verbal and Analogy training resulted in significant increases in weight-shift amplitude in both groups, and a corresponding pronounced reduction in unsuccessful attempts to initiate stepping (FoG-F group). Conclusions Hypometric preparatory weight-shifting is associated with failure to initiate forward stepping in people with Parkinson’s and FoG. However, impaired weight-shift characteristics are modifiable through conscious strategies. This current study provides a novel and critical evaluation of preparatory weight-shift amplitudes during FoG events. The intervention described represents an attractive ‘rescue’ strategy and should be further scrutinised regarding limitations posed by physical and cognitive deficits.

P30-S Impact of attentional abilities on step initiation in Parkinsonian patients with freezing of gait

2019 ◽  
Vol 130 (7) ◽  
pp. e103
Author(s):  
Madli Bayot ◽  
Aurore Braquet ◽  
Céline Tard ◽  
Luc Defebvre ◽  
Kathy Dujardin ◽  
...  
Keyword(s):  
Freezing Of Gait ◽  
Step Initiation

Relationship Between Brain Volumes and Objective Balance and Gait Measures in Parkinson’s Disease

2021 ◽  
pp. 1-12
Author(s):  
Anjanibhargavi Ragothaman ◽  
Oscar Miranda-Dominguez ◽  
Barbara H. Brumbach ◽  
Andrew Giritharan ◽  
Damien A. Fair ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rating Scales ◽  
Freezing Of Gait ◽  
Time Variability ◽  
Healthy Controls ◽  
Brain Volumes ◽  
Step Initiation ◽  
Subcortical Region ◽  
Postural Responses

Background: Instrumented measures of balance and gait measure more specific balance and gait impairments than clinical rating scales. No prior studies have used objective balance/gait measures to examine associations with ventricular and brain volumes in people with Parkinson’s disease (PD). Objective: To test the hypothesis that larger ventricular and smaller cortical and subcortical volumes are associated with impaired balance and gait in people with PD. Methods: Regional volumes from structural brain images were included from 96 PD and 50 control subjects. Wearable inertial sensors quantified gait, anticipatory postural adjustments prior to step initiation (APAs), postural responses to a manual push, and standing postural sway on a foam surface. Multiple linear regression models assessed the relationship between brain volumes and balance/gait and their interactions in PD and controls, controlling for sex, age and corrected for multiple comparisons. Results: Smaller brainstem and subcortical gray matter volumes were associated with larger sway area in people with PD, but not healthy controls. In contrast, larger ventricle volume was associated with smaller APAs in healthy controls, but not in people with PD. A sub-analysis in PD showed significant interactions between freezers and non-freezers, in several subcortical areas with stride time variability, gait speed and step initiation. Conclusion: Our models indicate that smaller subcortical and brainstem volumes may be indicators of standing balance dysfunction in people with PD whereas enlarged ventricles may be related to step initiation difficulties in healthy aging. Also, multiple subcortical region atrophy may be associated with freezing of gait in PD.

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