Substance P effects on blood flow, fluid transport and vasoactive intestinal polypeptide release in the feline small intestine.

Immunocytochemical studies habe shown that many peptides which profoundly affect the endocrine and exocrine functions of the pancreas are localized to neurons. In the cat, such peptidergic nerves appear to innervate ganglia, islets and blood vessels of the pancreas, whereas their contributions to exocrine cells are minor. Our studies suggest that pancreatic ganglia represent one major site of action of the peptides and that, in addition, nerves containing the vasoactive intestinal polypeptide and gastrin/CCK-related peptides profoundly affect pancreatic blood flow and insulin secretion, respectively.

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Density of Substance P, Vasoactive Intestinal Polypeptide and Somatostatin-Containing Nerve Fibers in the Ageing Small Intestine of the Rats

Gerontology ◽

10.1159/000212901 ◽

1987 ◽

Vol 33 (6) ◽

pp. 341-348 ◽

Cited By ~ 37

Author(s):

Erzsébet Fehér ◽

L. Pénzes

Keyword(s):

Small Intestine ◽

Substance P ◽

Vasoactive Intestinal Polypeptide ◽

Nerve Fibers ◽

Intestinal Polypeptide

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Age-related changes in substance P and vasoactive intestinal polypeptide immunoreactivity in the rat stomach and small intestine

Archives of Gerontology and Geriatrics ◽

10.1016/0167-4943(91)90018-l ◽

1991 ◽

Vol 13 (1) ◽

pp. 81-87 ◽

Cited By ~ 7

Author(s):

Fabio Ferrante ◽

Pierangelo Geppetti ◽

Francesco Amenta

Keyword(s):

Small Intestine ◽

Substance P ◽

Vasoactive Intestinal Polypeptide ◽

Rat Stomach ◽

Age Related ◽

Age Related Changes ◽

Intestinal Polypeptide

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Effects of Substance P and Vasoactive Intestinal Polypeptide on Gastrointestinal Blood Flow in the Atlantic Cod Gadus Morhua

Journal of Experimental Biology ◽

10.1242/jeb.156.1.361 ◽

1991 ◽

Vol 156 (1) ◽

pp. 361-373 ◽

Cited By ~ 5

Author(s):

JÖRGEN JENSEN ◽

MICHAEL AXELSSON ◽

SUSANNE HOLMGREN

Keyword(s):

Blood Flow ◽

Cardiac Output ◽

Substance P ◽

Vasoactive Intestinal Polypeptide ◽

Gadus Morhua ◽

Atlantic Cod ◽

Artery Blood Flow ◽

Coeliac Artery ◽

Gastrointestinal Blood Flow ◽

Intestinal Polypeptide

The cardiovascular effects of vasoactive intestinal polypeptide (VIP) and substance P (SP) in vivo were studied in the Atlantic cod Gadus morhua. Special interest was focused on the distribution of blood to the gastrointestinal circulation. VIP increased the blood flow to the gut by increasing cardiac output and by decreasing resistance in the vascular bed supplied by the coeliac artery. In addition, VIP had an inhibitory effect on spontaneous stomach motility. SP induced a triphasic response in the coeliac artery blood flow. An initial increase was followed by a rapid decrease, to the control level or below, and a second increase in flow. The triphasic response was not changed after vagotomy, while atropine blocked the second phase, the decrease, indicating that a local cholinergic mechanism is involved. The significance of this temporary decrease in flow remains to be elucidated. SP also caused an increase in cardiac output and in mesenteric artery blood flow. In addition to the increase in cardiac output, the increase in gastrointestinal blood flow produced by SP is accomplished by a decreased resistance in the coeliac and mesenteric vascular beds.

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