Experimental teaching is an important part of higher education. It has an effect that cannot be replaced on training innovative talents. The experimental teaching reform must be carried out to really realize the cultivation of innovative talents. This paper introduces the basic concepts of CDIO, and analyzes the deficiency of the traditional experimental teaching based on CDIO engineering theory. Teaching method, teaching patterns and so on is carried on the beneficial discussion and in practice. Some reform measures are put forward. Good teaching effect is obtained. The students' learning enthusiasm and innovation practice ability is greatly enhanced.