Bench-Top Validation Tests for Tissue-Engineered Arteries

2000 ◽  
Author(s):  
Shawn Chin Quee ◽  
Hai-Chao Han ◽  
David N. Ku

Abstract Standard tests are needed for evaluating and comparing the mechanical and biological functions of tissue engineered arteries and other vascular grafts. We propose an ex vivo organ culture system as a living system for testing tissue-engineered vascular grafts. This bench-top organ culture system mimics the physiological environment of arteries including the flow, pressure, and the axial stretch. Arterial mechanical properties and physiologic functions including compliance, burst pressure, and contractile functions can be assessed before an expensive long-term animal test is initiated. Test results of natural arteries indicate that organ culture is a valid model for comprehensive evaluation of tissue-engineered vascular grafts.

2000 ◽  
Author(s):  
Hai-Chao Han ◽  
Raymond P. Vito ◽  
Kristin Michael ◽  
David N. Ku

Abstract To study the effect of axial stretch on vascular function and wall remodeling, porcine carotid arteries were cultured under conditions of physiological flow and elevated axial stretch in an ex vivo organ culture system. Smooth muscle cell proliferation was measured by bromodeoxyuridine index. Results showed that cell proliferation was significantly increased in the highly stretched arteries when compared to the normally stretched arteries. This may indicate the feasibility of stimulating new arterial growth by stretching natural arteries.


Spine ◽  
2011 ◽  
Vol 36 (22) ◽  
pp. 1835-1842 ◽  
Author(s):  
Rahul Gawri ◽  
Fackson Mwale ◽  
Jean Ouellet ◽  
Peter J. Roughley ◽  
Thomas Steffen ◽  
...  

2016 ◽  
Vol 6 (1_suppl) ◽  
pp. s-0036-1582897-s-0036-1582897
Author(s):  
Michael Grant ◽  
Laura Epure ◽  
Omar Salem ◽  
Motaz Alaqeel ◽  
John Antoniou ◽  
...  

2001 ◽  
Vol 293 (4) ◽  
pp. 184-190 ◽  
Author(s):  
Arjen R. Companjen ◽  
L. I. van der Wel ◽  
Liu Wei ◽  
J. D. Laman ◽  
E. P. Prens

Sign in / Sign up

Export Citation Format

Share Document