Effects of Endplate and Mechanical Loading on Solute Transport in Intervertebral Disc

2008 ◽  
Author(s):  
Yongren Wu ◽  
John Glaser ◽  
Hai Yao
Keyword(s):  
Finite Element ◽  
Intervertebral Disc ◽  
Finite Element Model ◽  
Solute Transport ◽  
Mechanical Loading ◽  
Disc Degeneration ◽  
Element Model ◽  
Nutrient Supply ◽  
Cartilage Endplate ◽  
Disc Cells

The intervertebral disc (IVD) is the largest cartilaginous structure in human body that contributes to flexibility and load support in the spine. To accomplish these functions, the disc has a unique architecture consisting of a centrally-located nucleus pulposus (NP) surrounded superiorly and inferiorly by cartilage endplates (CEP) and peripherally by the annulus fibrosus (AF). Disc degeneration is strongly linked to low back pain. Poor nutrient supply has been suggested as a potential mechanism for disc degeneration. Previous theoretical studies have shown that the distributions of nutrients and metabolites (e.g., oxygen, glucose, and lactate) within the IVD depended on tissue diffusivities, nutrient supply, and cellular metabolic rates [1, 2]. Based on a multiphasic mechano-electrochemical finite element model of human IVD [3], our recent theoretical study suggested that the mechanical loading has little effect on small solute transport (e.g., glucose), but significantly affects large solute transport (e.g., growth factor). The objective of this study was to further develop the multiphasic finite element model of IVD by including the cartilage endplate and considering the nutrient consumption of disc cells. Using this model, the effects of endplate and mechanical loading on solute transport in IVD were examined.

Multiphasic Mechano-Electrochemical Finite Element Model of Human Intervertebral Disc

2007 ◽  
Author(s):  
Hai Yao ◽  
Wei Yong Gu
Keyword(s):  
Finite Element ◽  
Intervertebral Disc ◽  
Finite Element Model ◽  
Mechanical Loading ◽  
Human Body ◽  
Physical Environment ◽  
Annulus Fibrosus ◽  
Three Dimensional ◽  
Element Model ◽  
Mechanical Loads

The intervertebral disc (IVD) is the largest cartilaginous structure in human body that contributes to flexibility and load support in the spine. To accomplish these functions, the disc has a unique architecture consisting of a centrally-located nucleus pulposus (NP) surrounded superiorly and inferiorly by cartilage endplates and peripherally by the annulus fibrosus (AF). Because the disc is avascular and experiences mechanical loads, the cells in IVD tissues live in a complex physical environment. Knowledge of mechanical, chemical and electrical signals within the tissue is important for understanding mechanobiology of IVD [1]. The objective of this study was to develop a three-dimensional (3D), inhomogeneous finite element model (FEM) for human IVD for analyzing the physical environment and solute transport within the tissue under different mechanical loading conditions. A case of IVD under axial compression was simulated and reported.

Biomechanical Effect of Lumbar Disc Degeneration Under Flexion/Extension: A Finite Element Model Study

2007 ◽  
Author(s):  
Lissette M. Ruberté ◽  
Raghu Natarajan ◽  
Gunnar B. J. Andersson
Keyword(s):  
Finite Element ◽  
Lumbar Spine ◽  
Finite Element Model ◽  
Disc Degeneration ◽  
Pathological Condition ◽  
Lumbar Disc ◽  
Element Model ◽  
Adjacent Segment ◽  
Lumbar Disc Degeneration ◽  
Flexion Extension

Degenerative disc disease (DDD) is a progressive pathological condition observed in 60 to 80% of the population [1]. It involves changes in both the biochemistry and morphology of the intervertebral disc and is associated with chronic low back pain, sciatica and adult scoliosis [2,3]. The most accepted theory of the effects of DDD on the kinematics of the spine is that proposed by Kirkaldy-Willis and Farfan which states that the condition initiates as a temporary dysfunction, followed by instability and then re-stabilization as the disease progresses [4]. Although there is no clear relationship between disc degeneration and the mechanical behavior of the lumbar spine, abnormal motion patterns either in the form of increased motion or erratic motion have been reported from studies on human cadaveric motion segments [5,6]. To date however no study has looked at how disc degeneration affects the adjacent segment mechanics. IN vivo testing is difficult for these purposes given that specimens are generally obtained from people at the later stages of life and consequently often display multiple pathologies. A finite element model is a viable alternative to study the mechanics of the segments adjacent to the diseased disc. It is hypothesized that moderate degeneration at one level will alter the kinematics of the whole lumbar spine.

scholarly journals Novel human intervertebral disc strain template to quantify regional three-dimensional strains in a population and compare to internal strains predicted by a finite element model

2016 ◽  
Vol 34 (7) ◽  
pp. 1264-1273 ◽  
Author(s):  
Brent L. Showalter ◽  
John F. DeLucca ◽  
John M. Peloquin ◽  
Daniel H. Cortes ◽  
Jonathon H. Yoder ◽  
...  
Keyword(s):  
Finite Element ◽  
Intervertebral Disc ◽  
Finite Element Model ◽  
Three Dimensional ◽  
Element Model ◽  
Internal Strains

scholarly journals A novel finite element model of the ovine lumbar intervertebral disc with anisotropic hyperelastic material properties

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0177088 ◽  
Author(s):  
Gloria Casaroli ◽  
Fabio Galbusera ◽  
René Jonas ◽  
Benedikt Schlager ◽  
Hans-Joachim Wilke ◽  
...  
Keyword(s):  
Finite Element ◽  
Intervertebral Disc ◽  
Finite Element Model ◽  
Material Properties ◽  
Element Model ◽  
Hyperelastic Material ◽  
Lumbar Intervertebral Disc

scholarly journals Biomechanics Of Human Lumbar Spine (L3 To L5) With Degenerative Disc Disease Using Finite Element Model

2019 ◽  
Vol 8 (6) ◽  
pp. 4609-4614
Keyword(s):  
Finite Element ◽  
Lumbar Spine ◽  
Finite Element Model ◽  
Disc Degeneration ◽  
Human Body ◽  
Lumbar Disc ◽  
Element Model ◽  
Human Spine ◽  
Human Lumbar Spine ◽  
Normal Human

Human spine is one of the complex structure of the human body. It provides the link between upper and lower extremities of the human body. It is estimated that at least 30% of people in the middle age group from thirty to fifty years have some degree of disc degeneration. Disc degeneration disease can affect the quality of life and in certain individual it can cause severe chronic pain if left untreated. The low back pain associated with lumbar disc degeneration is usually generated from two causes which are abnormal motion instability and inflammation. Abnormal motion instability occurs when the annulus fibrosus are worn down and cannot absorb stress on the human spine effectively resulting in changes in movements along the vertebral segment. To understand lumbar disc problem, a thorough knowledge of the biomechanics of the normal human lumbar spine and a disc degenerated lumbar spine is of great importance. In this study, Computed tomography image of a 33 year old male is used. A three dimensional (3D) human lumbar spine (L3 to L5) is created and validated with literature. The finite element model was modified to degenerated disc and studied the biomechanics of the lumbar spine. Comparison of the biomechanics of normal human lumbar spine is done with the human lumbar spine with disc degeneration for different range of motion and different loads. The result shows that the pressure generated on degenerated disc is greater than normal disc. This work can be implemented and used for designing implants and also for intervertebral disc related analysis

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