We present a novel pulsed-train near-IR diode laser system with real-time temperature monitoring of the laser-heated cancer cell mixed in gold nanorod solution. Near-IR diode laser at 808 nm matching the gold nanorod absorption peak (with an aspect ratio about 4.0) was used in this study. Both surface and volume temperatures were measured and kept above 43°C, the temperature for cancer cells destruction. The irradiation time needed in our pulsed-train system with higher laser fluence for killing the cancel cells is about 1–3 minutes, much shorter than conventional methods (5–10 minutes). Cell viabilities in gold nanorod mixed and controlled solutions are studied by green fluorescence.
We present a novel external cavity diode laser design developed for atomic physics which employs a micromachined silicon flexure to sweep the laser frequency and a volume holographic reflection grating (VHG) to provide the optical feedback. The advantages of using a silicon flexure are its simple microfabrication process and reduction of the overall size of the laser system. The results demonstrate an optimized threshold current reduction from 59mA to 43mA, a frequency sweeping range of 2.069 GHz, and 87Rb, 85Rb (Rubidium) D2 line absorption at 780 nm.
In Vitro Photothermal Destruction of Cancer Cells Using Gold Nanorods and Pulsed-Train Near-Infrared Laser
