A standardized approach to validate solid phantom recipes for 3D anthropomorphic phantoms in biophotonics

Author(s):  
Sanathana Konugolu Venkata Sekar ◽  
Treasa Jiang ◽  
Pranav Lanka ◽  
Claudia Nunzia Gaudagno ◽  
Andrea Pacheco ◽  
...  
2015 ◽  
Vol 31 (8) ◽  
pp. 882-888 ◽  
Author(s):  
Stephen Inkoom ◽  
Maria Raissaki ◽  
Kostas Perisinakis ◽  
Thomas G. Maris ◽  
John Damilakis

Cancers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1709 ◽  
Author(s):  
Curto ◽  
Aklan ◽  
Mulder ◽  
Mils ◽  
Schmidt ◽  
...  

Clinical outcome of hyperthermia depends on the achieved target temperature, therefore target conformal heating is essential. Currently, invasive temperature probe measurements are the gold standard for temperature monitoring, however, they only provide limited sparse data. In contrast, magnetic resonance thermometry (MRT) provides unique capabilities to non-invasively measure the 3D-temperature. This study investigates MRT accuracy for MR-hyperthermia hybrid systems located at five European institutions while heating a centric or eccentric target in anthropomorphic phantoms with pelvic and spine structures. Scatter plots, root mean square error (RMSE) and Bland–Altman analysis were used to quantify accuracy of MRT compared to high resistance thermistor probe measurements. For all institutions, a linear relation between MRT and thermistor probes measurements was found with R2 (mean ± standard deviation) of 0.97 ± 0.03 and 0.97 ± 0.02, respectively for centric and eccentric heating targets. The RMSE was found to be 0.52 ± 0.31 °C and 0.30 ± 0.20 °C, respectively. The Bland-Altman evaluation showed a mean difference of 0.46 ± 0.20 °C and 0.13 ± 0.08 °C, respectively. This first multi-institutional evaluation of MR-hyperthermia hybrid systems indicates comparable device performance and good agreement between MRT and thermistor probes measurements. This forms the basis to standardize treatments in multi-institution studies of MR-guided hyperthermia and to elucidate thermal dose-effect relations.


Author(s):  
V. Chumak ◽  
◽  
N. Petrenko ◽  
O. Bakhanova ◽  
V. Voloskyi ◽  
...  

In the dosimetry of ionizing radiation, the phantoms of the human body, which are used as a replacement for the human body in physical measurements and calculations, play an important, but sometimes underestimated, role. There are physical phantoms used directly for measurements, and mathematical phantoms for computational dosimetry. Their complexity varies from simple geometry applied for calibration purposes up to very complex, which simulates in detail the shapes of organs and tissues of the human body. The use of physical anthropomorphic phantoms makes it possible to effectively optimize radiation doses by adjusting the parameters of CT-scanning (computed tomography) in accordance with the characteristics of the patient without compromising image quality. The use of phantoms is an indispensable approach to estimate the actual doses to the organs or to determine the effective dose of workers – values that are regulated, but cannot be directly measured. The article contains an overview of types, designs and the fields of application of anthropomorphic heterogeneous physical phantoms of a human with special emphasis on their use for validation of models and methods of computational dosimetry. Key words: dose, ionizing radiation, physical, mathematical phantoms, computational dosimetry.


2009 ◽  
Vol 82 (984) ◽  
pp. 1010-1018 ◽  
Author(s):  
K Fujii ◽  
T Aoyama ◽  
C Yamauchi-Kawaura ◽  
S Koyama ◽  
M Yamauchi ◽  
...  

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