TH-C-224C-06: Using Quality of Life Information to Rationally Incorporate Normal Tissue Effects Into Treatment Plan Evaluation and Scoring

2006 ◽  
Vol 33 (6Part22) ◽  
pp. 2274-2274
Author(s):  
M Miften ◽  
O Gayou ◽  
D Parda ◽  
L Marks

To achieve the optimal treatment goal, radiobiological parameters have to evaluate and predict the outcome of this treatment plan in terms of both TCP and NTCP. Different types of radiobiological model were used to achieve prescribed treatment dose of radiation during the tumor control. Where TCP models play an important role in order to achieve desired dose to the tumor. A suitable NTCP model was theoretically found among different models that can be used in treatment plan evaluation. Theoretically, six different radiobiological dose response models were analyzed in this project. Lyman–Kutcher–Burman, Critical element, critical volume, Relative Seriality, Parallel architecture, Weibull distribution models were analyzed from the derivation. All models were discussed elaborately with its various parameters and were used in the calculation of normal tissue complication probability during the treatment in radiotherapy. Further, all models were compared with each other. The models denote the dose for 50% complication probability (D50) parameters is the most commonly used radiobiological models for the normal tissues. The functional subunit response models (critical element & Relative seriality, Critical Volume, parallel architecture) are used in the derivation of the formulae for the normal tissue. Since all complicated NTCP model predict same as the simple NTCP model that is Lyman–Kutcher–Burman model as well as it is computationally efficient. Also Lyman–Kutcher–Burman model can be used in different treatment planning system incorporating with other model. For this reason, our suggested model is Lyman–Kutcher–Burman NTCP model which can be used in treatment plan evaluation. After analyzing six different model of NTCP, finding of the study is the treatment plan evaluation in where Lyman–Kutcher–Burman model is the best model for biological plan evaluation.


2011 ◽  
Vol 2 ◽  
pp. 74-83
Author(s):  
Courtney Knaup ◽  
Panayiotis Mavroidis ◽  
Carlos Esquivel ◽  
Dimos Baltas ◽  
Sotirios Stathakis ◽  
...  

2021 ◽  
Vol 161 ◽  
pp. S112-S114
Author(s):  
A. van der Schaaf ◽  
H.P. van der Laan ◽  
L. Van den Bosch ◽  
E. Korevaar ◽  
S. Both ◽  
...  

2018 ◽  
Vol 34 (5) ◽  
pp. 368-373
Author(s):  
Stacey Hoya ◽  
Linda Wogeman ◽  
Sara Allstadt ◽  
Glen King

Sonography currently provides a variety of tools to support the diagnosis and treatment of osteosarcoma and, with the development of therapeutic ultrasound practices, could play an increasingly important role in the treatment of future patients with osteosarcoma. Currently, computed tomography, magnetic resonance imaging, and radiography are the preferred imaging modalities for bone lesions; treatment options for osteosarcoma primarily include highly toxic chemotherapies and surgeries that often result in limb loss. Unfortunately, osteosarcoma is rarely eliminated, and despite this, patients lose their lives after having a significant reduction in quality of life. Evolving therapies such as high-frequency focused ultrasound, ultrasound-enhanced delivery of photodynamic therapy, and low-intensity pulsed ultrasound may offer these patients an improved quality of life while also increasing efficacy of treatment. This canine case study illustrates the various ways in which sonography might contribute to the treatment plan for patients with osteosarcoma. It may provide a comparable model for the reimagining of treatment for future patients with osteosarcoma using a suite of therapeutic ultrasound applications.


2020 ◽  
Vol 22 (2) ◽  
pp. 146-150
Author(s):  
Mariana Lima da Costa Valente ◽  
Marcela Silva Costa ◽  
Paulo Marcos Bérgamo ◽  
Denise Tornavoi de Castro

Currently, aesthetics, and especially the smile, adds considerable social value. In this way, patients suffering from dental loss wish that their rehabilitation be performed quickly and safely. The aim of oral rehabilitation is to restore masticatory, phonetic, aesthetic and quality of life to the patient. The diagnostic step is one of the most important and relevant steps in establishing a correct treatment plan and, in this way, it is possible to obtain excellent results. The present study aimed to demonstrate the importance of diagnostic waxing in oral rehabilitation. Patient sought treatment at the Dental Prosthesis Specialization Course at Odonto School, due to complaints associated with aesthetics and function. To improve their quality of life, planning of case was carried out through diagnostic waxing and a prosthetic solution was proposed. At the end of treatment and during the follow-up of the case, the patient reported satisfaction and significant improvement in quality of life. It can be concluded that the diagnostic waxing presents customized solutions offering, through a previous study, an effective clinical resolution to the patient. Keywords: Mouth Rehabilitation. Dental Restoration, Temporary. Dental Restoration, Temporary. Resumo Atualmente, a estética, e em especial o sorriso, agregam um valor social considerável. Dessa forma, ao sofrerem a perda dental, os pacientes desejam que sua reabilitação seja realizada de forma rápida e segura. A reabilitação oral tem como objetivo devolver ao paciente a eficiência mastigatória, fonética, estética e a qualidade de vida. A etapa diagnóstica constitui um dos passos mais importantes e relevantes no estabelecimento de um correto planejamento do tratamento e, desta forma, torna-se possível obter resultados de excelência. O presente estudo teve como objetivo demonstrar a importância do enceramento diagnóstico na reabilitação oral. Paciente procurou tratamento no Curso de Especialização em Prótese Dentária da Odonto School, devido a queixas associadas a estética e função. Para melhorar sua qualidade de vida, foi realizado o planejamento do caso por meio do enceramento diagnóstico e uma solução protética foi proposta. Ao final do tratamento e durante o acompanhamento do caso, a paciente relatou satisfação e melhora significativa na qualidade de vida. Pode-se concluir que o enceramento diagnóstico apresenta soluções personalizadas oferecendo, por meio de estudo prévio, uma resolução clínica efetiva ao paciente. Palavras-chave: Reabilitação Bucal. Restauração Dentária Temporária. Prótese Dentária Temporária.


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