Analysis of the three-dimensional tongue shape using a three-index factor analysis model

2003 ◽  
Vol 113 (1) ◽  
pp. 478-486 ◽  
Author(s):  
Yanli Zheng ◽  
Mark Hasegawa-Johnson ◽  
Shamala Pizza
Keyword(s):  
Factor Analysis ◽  
Three Dimensional ◽  
Analysis Model ◽  
Factor Analysis Model

Noniterative Estimation for the Multiple Battery Factor Analysis Model

1997 ◽  
Vol 24 (1) ◽  
pp. 3-18 ◽  
Author(s):  
Michael W. Browne ◽  
Krishna Tateneni
Keyword(s):  
Factor Analysis ◽  
Analysis Model ◽  
Factor Analysis Model

A Factor Analysis model of the instrumented Timed Up and Go test for physical capability assessment

2018 ◽  
Vol 66 ◽  
pp. S11-S12 ◽  
Author(s):  
A. Coni ◽  
S. Mellone ◽  
M. Colpo ◽  
S. Bandinelli ◽  
L. Chiari
Keyword(s):  
Factor Analysis ◽  
Analysis Model ◽  
Timed Up And Go ◽  
Factor Analysis Model ◽  
Physical Capability

scholarly journals Non-negative Independent Factor Analysis for single cell RNA-seq

2020 ◽  
Author(s):  
Weiguang Mao ◽  
Maziyar Baran Pouyan ◽  
Dennis Kostka ◽  
Maria Chikina
Keyword(s):  
Factor Analysis ◽  
Single Cell ◽  
Matrix Factorization ◽  
Component Analysis ◽  
Computational Techniques ◽  
Cell Type ◽  
Analysis Model ◽  
Factor Analysis Model ◽  
Type Identity ◽  
Wide Range

AbstractMotivationSingle cell RNA sequencing (scRNA-seq) enables transcriptional profiling at the level of individual cells. With the emergence of high-throughput platforms datasets comprising tens of thousands or more cells have become routine, and the technology is having an impact across a wide range of biomedical subject areas. However, scRNA-seq data are high-dimensional and affected by noise, so that scalable and robust computational techniques are needed for meaningful analysis, visualization and interpretation. Specifically, a range of matrix factorization techniques have been employed to aid scRNA-seq data analysis. In this context we note that sources contributing to biological variability between cells can be discrete (or multi-modal, for instance cell-types), or continuous (e.g. pathway activity). However, no current matrix factorization approach is set up to jointly infer such mixed sources of variability.ResultsTo address this shortcoming, we present a new probabilistic single-cell factor analysis model, Non-negative Independent Factor Analysis (NIFA), that combines features of complementary approaches like Independent Component Analysis (ICA), Principal Component Analysis (PCA), and Non-negative Matrix Factorization (NMF). NIFA simultaneously models uni- and multi-modal latent factors and can so isolate discrete cell-type identity and continuous pathway-level variations into separate components. Similar to NMF, NIFA constrains factor loadings to be non-negative in order to increase biological interpretability. We apply our approach to a range of data sets where cell-type identity is known, and we show that NIFA-derived factors outperform results from ICA, PCA and NMF in terms of cell-type identification and biological interpretability. Studying an immunotherapy dataset in detail, we show that NIFA identifies biomedically meaningful sources of variation, derive an improved expression signature for regulatory T-cells, and identify a novel myeloid cell subtype associated with treatment response. Overall, NIFA is a general approach advancing scRNA-seq analysis capabilities and it allows researchers to better take advantage of their data. NIFA is available at https://github.com/wgmao/[email protected]

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