scholarly journals Dependence of inertial cavitation induced by high intensity focused ultrasound on transducer F-number and nonlinear waveform distortion

2018 ◽  
Vol 144 (3) ◽  
pp. 1160-1169 ◽  
Author(s):  
Tatiana Khokhlova ◽  
Pavel Rosnitskiy ◽  
Christopher Hunter ◽  
Adam Maxwell ◽  
Wayne Kreider ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Inertial Cavitation ◽  
Waveform Distortion

scholarly journals Investigation of the Inertial Cavitation Activity of Sonosensitive and Biocompatible Nanoparticles for Drug Delivery Applications Employing High Intensity Focused Ultrasound

2019 ◽  
Vol 5 (1) ◽  
pp. 585-588
Author(s):  
Benedikt George ◽  
Michael Fink ◽  
Helmut Ermert ◽  
Stefan J. Rupitsch ◽  
Pia T. Hiltl ◽  
...  
Keyword(s):  
Drug Release ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Active Drug ◽  
Drug Carriers ◽  
High Intensity Focused Ultrasound ◽  
Activity Level ◽  
Inertial Cavitation ◽  
Cavitation Effect ◽  
Cavitation Activity

AbstractAn approach to improve chemotherapy, while minimizing side effects, is a local drug release close to the tumorous tissue. For this purpose, the active drug component is often bound to nanoparticles employed as drug carriers. In the present study, we investigate sonosensitive, biocompatible poly-(L)-lactic acid (PLA) nanoparticles, which shall be used as drug carriers. For drug release, High Intensity Focused Ultrasound (HIFU) will be employed to introduce inertial cavitation, which separates the active drug component from the drug carrier. The cavitation effect generates an acoustic noise signal, which characterizes the cavitation activity and is expected to serve simultaneously as an indicator for the release of the active drug component. Depending on the ultrasound frequency, different acoustic levels of the inertial cavitation activity were measured. Investigations using a setup for passive cavitation detection (PCD) deliver quantitative results regarding the frequency dependence of the cavitation activity level of nanoparticles and reference media.

Effect of high intensity focused ultrasound transducer F-number and waveform non-linearity on inertial cavitation activity

2018 ◽  
Vol 144 (3) ◽  
pp. 1824-1824 ◽  
Author(s):  
Christopher Bawiec ◽  
Christopher Hunter ◽  
Wayne Kreider ◽  
Adam D. Maxwell ◽  
Vera A. Khokhlova ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound Transducer ◽  
Inertial Cavitation ◽  
Cavitation Activity

Dependence of inertial cavitation activity on the high intensity focused ultrasound transducer F-number

2016 ◽  
Vol 140 (4) ◽  
pp. 2983-2983
Author(s):  
Tatiana Khokhlova ◽  
Christopher Hunter ◽  
Wayne Kreider ◽  
Adam Maxwell ◽  
Vera Khokhlova ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound Transducer ◽  
Inertial Cavitation ◽  
Cavitation Activity

260: High Intensity Focused Ultrasound Combined with Endocrine Therapy in Treating High or Intermediate Risk Prostate Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 86-86
Author(s):  
Makoto Sumitomo ◽  
Junichi Asakuma ◽  
Yasumasa Hanawa ◽  
Kazuhiko Nagakura ◽  
Masamichi Hayakawa
Keyword(s):  
Prostate Cancer ◽  
Endocrine Therapy ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Intermediate Risk ◽  
Risk Prostate Cancer

1400: Early Clinical Experience Using High-Intensity Focused Ultrasound for the Treatment of Renal Tumours

2005 ◽  
Vol 173 (4S) ◽  
pp. 379-380
Author(s):  
James E. Kennedy ◽  
Rowland O. Illing ◽  
Feng Wu ◽  
Gail R. ter Haar ◽  
Rachel R. Phillips ◽  
...  
Keyword(s):  
Clinical Experience ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Early Clinical Experience ◽  
Renal Tumours

High-Intensity Focused Ultrasound

1994 ◽  
Vol 4 (2) ◽  
pp. 383-395 ◽  
Author(s):  
Narendra T. Sanghvi ◽  
Robert H. Hawes
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound

Abstract #593 High Intensity Focused Ultrasound (HIFU) in the Treatment of Thyroid Nodules. Efficacy, Side-Effects and Predictive Factors of Clinical Outcome

2019 ◽  
Vol 25 ◽  
pp. 304-305
Author(s):  
Enrico Papini ◽  
Agnese Persichetti ◽  
Antonio Bianchini ◽  
Carmela Coccaro ◽  
Marco Chianelli ◽  
...  
Keyword(s):  
Side Effects ◽  
Clinical Outcome ◽  
Predictive Factors ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Thyroid Nodules ◽  
High Intensity Focused Ultrasound

Das Prostatakarzinom: aktuelle Diagnostik und Therapiestandard

Praxis ◽  
2016 ◽  
Vol 105 (16) ◽  
pp. 971-977
Author(s):  
Jan Brachlow ◽  
Martin Kälin ◽  
Marco Randazzo ◽  
Beat Förster ◽  
Hubert John
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Psa Test ◽  
Eine Hohe ◽  
Psa Screening ◽  
Sekundäre Hormontherapie

Zusammenfassung. Das Prostatakarzinom zeigt eine hohe Prävalenz und ist daher für die behandelnden Ärzte medizinisch, aber auch gesundheitspolitisch relevant. PSA-Screening senkt die karzinomspezifische Mortalität, ist jedoch aufgrund der hohen Prävalenz mit einer Überdiagnostik verbunden. Dies fordert im Gegenzug einen verantwortungsbewussten Umgang mit dem PSA-Test («smarter screening»). Durch die robotergestützte Prostatektomie steht eine Therapie mit geringer Morbidität zur Behandlung des lokalisierten Prostatakarzinoms zur Verfügung. Das fokale Behandlungskonzept der HIFU (high-intensity focused ultrasound) ist vielversprechend, jedoch noch klinisch experimentell und sollte im Rahmen von Studien angeboten werden. Die Behandlungsmöglichkeiten beim metastasierten Prostatakarzinom wurden entscheidend vervielfältigt. Chemotherapie und die sekundäre Hormontherapie werden voraussichtlich vermehrt in früheren Phasen der Krankheit eine Rolle spielen, wodurch die Therapie für den einzelnen Patienten immer komplexer wird und individuell angepasst werden muss.

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