scholarly journals Investigation of the Inertial Cavitation Activity of Sonosensitive and Biocompatible Nanoparticles for Drug Delivery Applications Employing High Intensity Focused Ultrasound

2019 ◽  
Vol 5 (1) ◽  
pp. 585-588
Author(s):  
Benedikt George ◽  
Michael Fink ◽  
Helmut Ermert ◽  
Stefan J. Rupitsch ◽  
Pia T. Hiltl ◽  
...  
Keyword(s):  
Drug Release ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Active Drug ◽  
Drug Carriers ◽  
High Intensity Focused Ultrasound ◽  
Activity Level ◽  
Inertial Cavitation ◽  
Cavitation Effect ◽  
Cavitation Activity

AbstractAn approach to improve chemotherapy, while minimizing side effects, is a local drug release close to the tumorous tissue. For this purpose, the active drug component is often bound to nanoparticles employed as drug carriers. In the present study, we investigate sonosensitive, biocompatible poly-(L)-lactic acid (PLA) nanoparticles, which shall be used as drug carriers. For drug release, High Intensity Focused Ultrasound (HIFU) will be employed to introduce inertial cavitation, which separates the active drug component from the drug carrier. The cavitation effect generates an acoustic noise signal, which characterizes the cavitation activity and is expected to serve simultaneously as an indicator for the release of the active drug component. Depending on the ultrasound frequency, different acoustic levels of the inertial cavitation activity were measured. Investigations using a setup for passive cavitation detection (PCD) deliver quantitative results regarding the frequency dependence of the cavitation activity level of nanoparticles and reference media.

Effect of high intensity focused ultrasound transducer F-number and waveform non-linearity on inertial cavitation activity

2018 ◽  
Vol 144 (3) ◽  
pp. 1824-1824 ◽  
Author(s):  
Christopher Bawiec ◽  
Christopher Hunter ◽  
Wayne Kreider ◽  
Adam D. Maxwell ◽  
Vera A. Khokhlova ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound Transducer ◽  
Inertial Cavitation ◽  
Cavitation Activity

scholarly journals Investigation of Inertial Cavitation of Sonosensitive and Biocompatible Nanoparticles in Flow - Through Tissue- Mimicking Phantoms Employing Focused Ultrasound

2021 ◽  
Vol 7 (2) ◽  
pp. 163-166
Author(s):  
Benedikt George ◽  
Ula Savšek ◽  
Dagmar Fischer ◽  
Helmut Ermert ◽  
Stefan J. Rupitsch
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Release ◽  
Focused Ultrasound ◽  
Vascular System ◽  
Drug Carriers ◽  
Inertial Cavitation ◽  
Cavitation Effect ◽  
Flow Through ◽  
Delivery Approach

Abstract A promising approach to drug delivery applications for chemotherapeutics is the use of drug carriers to reduce the total amount of cytostatics, minimizing side effects. In addition, the carriers, loaded with the drug, can be guided to the tumorous tissue via the vascular system, which enables a local drug release (LDR). In our case, LDR is activated due to the sonosensitive behavior of the nanocapsules by inertial cavitation (IC) caused by focused ultrasound (FUS). Thereby, IC is excited by employing sound pressures within the recommended limit allowed for diagnostic ultrasound. In order to verify this drug delivery approach for its clinical suitability, a tissue-mimicking flow -through phantom, containing a small vessel, is used. Investigations have shown that the drug releasing cavitation effect associated with the sonosensitive and biocompatible nanocapsules also occurs in fine vessel structures, even in the case of moving particles and vessel diameters dc smaller than the wavelength λ.

Dependence of inertial cavitation activity on the high intensity focused ultrasound transducer F-number

2016 ◽  
Vol 140 (4) ◽  
pp. 2983-2983
Author(s):  
Tatiana Khokhlova ◽  
Christopher Hunter ◽  
Wayne Kreider ◽  
Adam Maxwell ◽  
Vera Khokhlova ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound Transducer ◽  
Inertial Cavitation ◽  
Cavitation Activity

scholarly journals Dependence of inertial cavitation induced by high intensity focused ultrasound on transducer F-number and nonlinear waveform distortion

2018 ◽  
Vol 144 (3) ◽  
pp. 1160-1169 ◽  
Author(s):  
Tatiana Khokhlova ◽  
Pavel Rosnitskiy ◽  
Christopher Hunter ◽  
Adam Maxwell ◽  
Wayne Kreider ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Inertial Cavitation ◽  
Waveform Distortion

scholarly journals Polylactic acid nano- and microchamber arrays for encapsulation of small hydrophilic molecules featuring drug release via high intensity focused ultrasound

Nanoscale ◽  
2017 ◽  
Vol 9 (21) ◽  
pp. 7063-7070 ◽  
Author(s):  
Meiyu Gai ◽  
Johannes Frueh ◽  
Tianyi Tao ◽  
Arseniy V. Petrov ◽  
Vladimir V. Petrov ◽  
...  
Keyword(s):  
Drug Release ◽  
Polylactic Acid ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound

Small hydrophilic molecules can be encapsulated in polylactic acid microchambers and released by HIFU.

scholarly journals Drug Release from Thermosensitive Liposomes by High-Intensity Focused Ultrasound

2014 ◽  
Vol 58 (6) ◽  
pp. 575-579 ◽  
Author(s):  
Ye Won Jeon ◽  
Sun Hang Cho ◽  
Hee Dong Han ◽  
Byung Cheol Shin
Keyword(s):  
Drug Release ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Thermosensitive Liposomes
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