In Vitro Metabolism of Pyrethroid Pesticides by Rat and Human Hepatic Microsomes and Cytochrome P450 Isoforms

2008 ◽  
Vol 37 (1) ◽  
pp. 221-228 ◽  
Author(s):  
Edward J. Scollon ◽  
James M. Starr ◽  
Stephen J. Godin ◽  
Michael J. DeVito ◽  
Michael F. Hughes
Keyword(s):  
Cytochrome P450 ◽  
In Vitro Metabolism ◽  
Hepatic Microsomes ◽  
Pyrethroid Pesticides ◽  
Cytochrome P450 Isoforms

Investigation of the in Vitro Metabolism of Evodiamine: Characterization of Metabolites and Involved Cytochrome P450 Isoforms

2012 ◽  
Vol 27 (5) ◽  
pp. 705-712 ◽  
Author(s):  
Hong-Zhi Sun ◽  
Zhong-Ze Fang ◽  
Yun-Feng Cao ◽  
Xiao-Yu Sun ◽  
Mo Hong
Keyword(s):  
Cytochrome P450 ◽  
In Vitro Metabolism ◽  
Cytochrome P450 Isoforms

Investigating the in vitro metabolism of veratridine: Characterization of metabolites and involved cytochrome P450 isoforms

2009 ◽  
Vol 877 (3) ◽  
pp. 141-148 ◽  
Author(s):  
Xuan Ye ◽  
Yuguang Wang ◽  
Minghui Yang ◽  
Qingqing Wang ◽  
Qiande Liang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
In Vitro Metabolism ◽  
Cytochrome P450 Isoforms

In vitro metabolism of toborinone by human liver cytochrome P450 isoforms

1998 ◽  
Vol 95 ◽  
pp. 101-102
Author(s):  
R. Abbas ◽  
D.A. Flockhart ◽  
D. Thacker ◽  
S.L. Bramer ◽  
D. Cowart ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
In Vitro Metabolism ◽  
Liver Cytochrome ◽  
Cytochrome P450 Isoforms

In vitro metabolism of alachlor by human liver microsomes and human cytochrome P450 isoforms

1999 ◽  
Vol 122 (1) ◽  
pp. 27-39 ◽  
Author(s):  
Scott Coleman ◽  
Siming Liu ◽  
Russell Linderman ◽  
Ernest Hodgson ◽  
Randy L Rose
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
In Vitro Metabolism ◽  
Human Cytochrome ◽  
Cytochrome P450 Isoforms

In vitro metabolism of cyclosporin A with rabbit renal or hepatic microsomes: analysis by HPLC-FPIA and HPLC-MS

1995 ◽  
Vol 69 (5) ◽  
pp. 346-349 ◽  
Author(s):  
C. Pham-Huy ◽  
N. Sadeg ◽  
T. Becue ◽  
C. Martin ◽  
G. Mahuzier ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
In Vitro Metabolism ◽  
Hepatic Microsomes

scholarly journals Phenobarbital influence on neuromuscular block produced by rocuronium in rats

2008 ◽  
Vol 23 (4) ◽  
pp. 343-347 ◽  
Author(s):  
Angélica de Fátima de Assunção Braga ◽  
Caroline Coutinho de Barcelos ◽  
Franklin Sarmento da Silva Braga ◽  
Samanta Cristina Antoniassi Fernandes ◽  
Yoko Oshima Franco ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Neuromuscular Blockade ◽  
Neuromuscular Block ◽  
Cytochrome B5 ◽  
Muscle Response ◽  
In Vivo Experiments ◽  
Hepatic Microsomes ◽  
Enzymatic Induction

PURPOSE: To evaluate in vitro and in vivo neuromuscular blockade produced by rocuronium in rats treated with Phenobarbital and to determine cytochrome P450 and cytochrome b5 concentrations in hepatic microsomes. METHODS: Thirty rats were included in the study and distributed into 6 groups of 5 animals each. Rats were treated for seven days with phenobarbital (20 mg/kg) and the following parameters were evaluated: 1) the amplitude of muscle response in the preparation of rats exposed to phenobarbital; 2) rocuronium effect on rat preparation exposed or not to phenobarbital; 3) concentrations of cytochrome P450 and cytochrome b5 in hepatic microsomes isolated from rats exposed or not to phenobarbital. The concentration and dose of rocuronium used in vitro and in vivo experiments were 4 µg/mL and 0,6 mg/kg, respectively. RESULTS: Phenobarbital in vitro and in vivo did not alter the amplitude of muscle response. The neuromuscular blockade in vitro produced by rocuronium was significantly different (p=0.019) between exposed (20%) and not exposed (60%) rats; the blockade in vivo was significantly greater (p=0.0081) in treated rats (93.4%). The enzymatic concentrations were significantly greater in rats exposed to phenobarbital. CONCLUSIONS: Phenobarbital alone did not compromise neuromuscular transmission. It produced enzymatic induction, and neuromuscular blockade in vivo produced by rocuronium was potentiated by phenobarbital.

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