In Vitro Metabolism of BIIB021, an Inhibitor of Heat Shock Protein 90, in Liver Microsomes and Hepatocytes of Rats, Dogs, and Humans and Recombinant Human Cytochrome P450 Isoforms

Lin Xu; Caroline Woodward; Samina Khan; Chandra Prakash

doi:10.1124/dmd.111.043000

In Vitro Metabolism of BIIB021, an Inhibitor of Heat Shock Protein 90, in Liver Microsomes and Hepatocytes of Rats, Dogs, and Humans and Recombinant Human Cytochrome P450 Isoforms

Drug Metabolism and Disposition ◽

10.1124/dmd.111.043000 ◽

2012 ◽

Vol 40 (4) ◽

pp. 680-693 ◽

Cited By ~ 10

Author(s):

Lin Xu ◽

Caroline Woodward ◽

Samina Khan ◽

Chandra Prakash

Keyword(s):

Cytochrome P450 ◽

Heat Shock ◽

Heat Shock Protein ◽

Liver Microsomes ◽

Heat Shock Protein 90 ◽

In Vitro Metabolism ◽

Human Cytochrome ◽

Cytochrome P450 Isoforms

Download Full-text

In vitro metabolism of alachlor by human liver microsomes and human cytochrome P450 isoforms

Chemico-Biological Interactions ◽

10.1016/s0009-2797(99)00107-6 ◽

1999 ◽

Vol 122 (1) ◽

pp. 27-39 ◽

Cited By ~ 38

Author(s):

Scott Coleman ◽

Siming Liu ◽

Russell Linderman ◽

Ernest Hodgson ◽

Randy L Rose

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

In Vitro Metabolism ◽

Human Cytochrome ◽

Cytochrome P450 Isoforms

Download Full-text

In Vitro Metabolism of a New Neuroprotective Agent, KR-31543 in the Human Liver Microsomes: Identification of Human Cytochrome P450

Archives of Pharmacal Research ◽

10.1007/bf02980112 ◽

2004 ◽

Vol 27 (2) ◽

pp. 239-245 ◽

Cited By ~ 4

Author(s):

Hye Young Ji ◽

Seung-Seok Lee ◽

Sung-Eun Yoo ◽

Hosoon Kim ◽

Dong Ha Lee ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

In Vitro Metabolism ◽

Neuroprotective Agent ◽

Human Cytochrome

Download Full-text

In vitro metabolism of a new oxazolidinedione hypoglycemic agent utilizing liver microsomes and recombinant human cytochrome P450 enzymes

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2004.10.036 ◽

2005 ◽

Vol 37 (2) ◽

pp. 351-358 ◽

Cited By ~ 8

Author(s):

Arun K. Agrawal ◽

Cornelis E.C.A. Hop ◽

Jianmei Pang ◽

Maria V. Silva Elipe ◽

Ranjit C. Desai ◽

...

Keyword(s):

Cytochrome P450 ◽

Liver Microsomes ◽

In Vitro Metabolism ◽

Cytochrome P450 Enzymes ◽

Hypoglycemic Agent ◽

Human Cytochrome

Download Full-text

Faculty Opinions recommendation of Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1082926.535884 ◽

2007 ◽

Author(s):

Homer Pearce

Keyword(s):

Heat Shock ◽

Heat Shock Protein ◽

Molecular Chaperone ◽

Heat Shock Protein 90

Download Full-text

Faculty Opinions recommendation of A pivotal role for heat shock protein 90 in Ewing sarcoma resistance to anti-insulin-like growth factor 1 receptor treatment: in vitro and in vivo study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1120094.576229 ◽

2008 ◽

Author(s):

Richard Riedel

Keyword(s):

Growth Factor ◽

Heat Shock ◽

Heat Shock Protein ◽

Ewing Sarcoma ◽

Heat Shock Protein 90 ◽

Pivotal Role ◽

In Vivo Study ◽

Insulin Like Growth Factor

Download Full-text

In vivo-in vitro correlation of antitumor activity of heat shock protein 90 (HSP90) inhibitors with a pharmacokinetics/pharmacodynamics analysis using NCI-N87 xenograft mice

Xenobiotica ◽

10.1080/00498254.2021.1942588 ◽

2021 ◽

pp. 1-30

Author(s):

Noriaki Ohminato ◽

Miho Nagayasu ◽

Kazuhisa Ozeki ◽

Ryoichi Saitoh ◽

Naomi Ono ◽

...

Keyword(s):

Heat Shock ◽

Antitumor Activity ◽

Heat Shock Protein ◽

Heat Shock Protein 90 ◽

Hsp90 Inhibitors ◽

Xenograft Mice

Download Full-text

Anti-piroplasmic activity of novobiocin as heat shock protein 90 inhibitor against in vitro cultured Theileria equi and Babesia caballi parasites

Ticks and Tick-borne Diseases ◽

10.1016/j.ttbdis.2021.101696 ◽

2021 ◽

pp. 101696

Author(s):

A. Suthar ◽

C. Maji ◽

A. Gopalkrishnan ◽

S.H. Raval ◽

R. Kumar ◽

...

Keyword(s):

Heat Shock ◽

Heat Shock Protein ◽

Heat Shock Protein 90 ◽

Theileria Equi ◽

Babesia Caballi

Download Full-text

Investigation of the in Vitro Metabolism of Evodiamine: Characterization of Metabolites and Involved Cytochrome P450 Isoforms

Phytotherapy Research ◽

10.1002/ptr.4766 ◽

2012 ◽

Vol 27 (5) ◽

pp. 705-712 ◽

Cited By ~ 17

Author(s):

Hong-Zhi Sun ◽

Zhong-Ze Fang ◽

Yun-Feng Cao ◽

Xiao-Yu Sun ◽

Mo Hong

Keyword(s):

Cytochrome P450 ◽

In Vitro Metabolism ◽

Cytochrome P450 Isoforms

Download Full-text

In vitro metabolism of helenalin and its inhibitory effect on human cytochrome P450 activity

Archives of Toxicology ◽

10.1007/s00204-021-03218-6 ◽

2022 ◽

Author(s):

Michaela Šadibolová ◽

Risto O. Juvonen ◽

Seppo Auriola ◽

Iva Boušová

Keyword(s):

Cytochrome P450 ◽

Inhibitory Effect ◽

In Vitro Metabolism ◽

Cytochrome P450 Activity ◽

Human Cytochrome ◽

P450 Activity

Download Full-text

Heat Shock Protein 90 (HSP90) Is Preferentially Overexpressed in P16-Negative Oropharyngeal Squamous Cell Carcinoma, and its Inhibition In Vitro Potentiates the Effects of Chemoradiation

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2014.05.736 ◽

2014 ◽

Vol 90 (1) ◽

pp. S195

Author(s):

K. Patel ◽

J. Wen ◽

K. Magliocca ◽

S. Muller ◽

Y. Liu ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Heat Shock ◽

Heat Shock Protein ◽

Cell Carcinoma ◽

Squamous Cell ◽

Heat Shock Protein 90 ◽

Oropharyngeal Squamous Cell Carcinoma

Download Full-text