scholarly journals Diabetes Mellitus Reduces Activity of Human UDP-Glucuronosyltransferase 2B7 in Liver and Kidney Leading to Decreased Formation of Mycophenolic Acid Acyl-Glucuronide Metabolite

2010 ◽  
Vol 39 (3) ◽  
pp. 448-455 ◽  
Author(s):  
Miroslav Dostalek ◽  
Michael H. Court ◽  
Suwagmani Hazarika ◽  
Fatemeh Akhlaghi
Keyword(s):  
Diabetes Mellitus ◽  
Mycophenolic Acid ◽  
Acyl Glucuronide ◽  
Liver And Kidney ◽  
Udp Glucuronosyltransferase ◽  
Glucuronide Metabolite

Proteins identified as targets of the acyl glucuronide metabolite of mycophenolic acid in kidney tissue from mycophenolate mofetil treated rats

Biochimie ◽  
2007 ◽  
Vol 89 (3) ◽  
pp. 393-402 ◽  
Author(s):  
Abdul R. Asif ◽  
Victor W. Armstrong ◽  
Antje Voland ◽  
Eberhard Wieland ◽  
Michael Oellerich ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Mycophenolic Acid ◽  
Kidney Tissue ◽  
Acyl Glucuronide ◽  
Glucuronide Metabolite

The acyl glucuronide metabolite of mycophenolic acid induces tubulin polymerization in vitro

2010 ◽  
Vol 43 (1-2) ◽  
pp. 208-213 ◽  
Author(s):  
Horst Feichtiger ◽  
Eberhard Wieland ◽  
Victor W. Armstrong ◽  
Maria Shipkova
Keyword(s):  
Mycophenolic Acid ◽  
Tubulin Polymerization ◽  
Acyl Glucuronide ◽  
Glucuronide Metabolite

The acyl glucuronide metabolite of mycophenolic acid inhibits the proliferation of human mononuclear leukocytes

2001 ◽  
Vol 33 (1-2) ◽  
pp. 1080-1081 ◽  
Author(s):  
M Shipkova ◽  
E Wieland ◽  
E Schütz ◽  
C Wiese ◽  
P.D Niedmann ◽  
...  
Keyword(s):  
Mycophenolic Acid ◽  
Mononuclear Leukocytes ◽  
Acyl Glucuronide ◽  
Human Mononuclear Leukocytes ◽  
Glucuronide Metabolite

Vasopressin V1 and V2 receptors in diabetes mellitus

1994 ◽  
Vol 266 (2) ◽  
pp. E217-E223 ◽  
Author(s):  
D. Trinder ◽  
P. A. Phillips ◽  
J. M. Stephenson ◽  
J. Risvanis ◽  
A. Aminian ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Inositol Phosphate ◽  
Free Water ◽  
Diabetic Rats ◽  
Biological Responses ◽  
Liver And Kidney ◽  
Streptozotocin Induced Diabetes ◽  
V2 Receptor ◽  
Plasma Arginine ◽  
Long Acting

Diabetes mellitus causes hypertonicity, increased plasma arginine vasopressin (AVP), polydipsia, and polyuria. Downregulation of AVP V2 receptors may contribute to the polyuria through diminished V2 receptor-mediated free water retention. After 2 wk of streptozotocin-induced diabetes mellitus, the diabetic rats had raised plasma glucose, AVP, and osmolality levels (P < 0.001) compared with nondiabetic controls (Sham). Insulin treatment (4 U long-acting insulin sc, daily) partially lowered these values (P < 0.01). There was a reduction in the number of renal and hepatic V1 receptors in the diabetic and diabetic+insulin animals compared with the sham animals (P < 0.05). The receptor affinity remained unchanged. In parallel, there was a reduction in maximum AVP-activated total inositol phosphate production in the liver and kidney of the diabetic and diabetic+insulin animals compared with the sham animals (P < 0.05). The density and affinity of renal V2 receptors and AVP-stimulated adenosine 3',5'-cyclic monophosphate production in the diabetic and diabetic+insulin animals were unchanged compared with the sham. These results demonstrate differential regulation of AVP receptors and suggest that downregulation of renal V2 receptors does not contribute to the polyuria of diabetes. In contrast, downregulation of V1 receptors might contribute to diminished V1 receptor-mediated biological responses to AVP seen in diabetes mellitus.

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