Fenugreek Seed

Fenugreek (Trigonella foenum graecum), native to southern Europe and Asia, is anannual herb with white flowers and hard, yellowish brown and angular seeds,known from ancient times, for nutritional value beside of it medicinal effects. Fenugreek seeds are rich source of gum, fiber, alkaloid, flavonoids, saponin and volatile content. Due to it's high content of fiber, fenugreek could be used as food stabilizer, adhesive and emulsifying agent to change food texture for some special purposes. Some evidences suggest that fenugreek may also be regarded as antidiabetic, anticarcinogenic, remedy for hypocholesterolemia and hypoglycemia, antioxidant, antibacterial agent, gastric stimulant, and anti-anorexia agent. The present article is aimed to review the potential applications of fenugreek as a functional food and nutraceutical. Keywords: Chemical composition, Fenugreek gum, Fenugreek, Health benefits

Design of Lipid Nanoparticles Containing Fenugreek Seed Extract

Background: The main purpose of this study was to maximize the efficacy of fenugreek seed extract by loading it in an optimised solid lipid nanoparticles (SLNs) formula. Methods: To achieve an effective extraction method, preliminary studies were carried out to confirm the extract, and the extract was standardised using trigonelline. The influence of independent variables lipid concentration (X1), surfactant concentration (X2), and cosurfactant concentration (X3) on dependent variables particle size (Y1) and entrapment efficiency (Y2) was also studied and optimised using the Box–Behnken design. Melt emulsification followed by ultrasonication was used to prepare SLN formulations. To understand the effect of independent variables on the dependent quality parameters, response surface plots and mathematical equations were produced. Results: The results confirmed that soxhalation was the most suitable method for extraction of fenugreek seeds, confirmed by standardization. Further optimization revealed that particle sizes ranged from 193.4 to 312.3 nm, with entrapment efficiencies ranging from 61.2 to 74.32 percent. This implies that the developed formulations can be used for further in vitro and in vivo characterizations.

Comparison of Antibacterial Efficacy of Fenugreek Seed Extract Rinse and Nigella Sativa Seed Extract Rinse against Streptococcus Mutant Colonies

Background: Dental infections were caused by the bacterium overgrowth on the surface of the tooth, and treatment should always be set up to prevent this development.Antibiotics have long been used as a conventional antibacterial medication, but their overuse has resulted in microbes gaining resistance to many of the antibiotics, trying to make many commercialized therapeutic remedies ineffectual and resulting to infection recurrence. In this regard we aim to analyze the antibacterial activity of nigella sativa seeds’ and fenugreek seed extract rinses against S. mutans' colonies. Methodology: It was a preclinical experimental study conducted at Baqai Medical and Dental College Karachi., from January - June 2021. Calculated sample size was n = 80 Consecutive sampling technique was used. Plaque of study participants was collected on sterile strips that was transported to laboratory for culture in sterile containers.The extract of Fenugreek seed and nigella sativa seed was kept in an airtight bottle and stored in a refrigerator till usage. The extracts were diluted in distilled water in 1:4 (Extract: Distilled water). Study participants were instructed to not brush their teeth before sampling. Study participants were divided into four groups (negative control, positive control, fenugreek seed extract group and Nigella sativa group) each group had 20 participants. Diluted Fenugreek seed extract and Nigella sativa extract was given to experimental groups for rinses. Results: There was significant decrease in number of colonies in positive controls, fenugreek seed extract group and nigella sativa extract group and there was no change in number of colonies in control group. Furthermore, the analysis showed significant (p-value = 0.001) difference among the groups followed by post hoc analysis. Post hoc analysis showed no difference between positive control, fenugreek seed extract group and nigella sativa group. Conclusion: Fenugreek seed extract and Nigella Sativa seed extract showed comparable antibacterial properties. Also, the effect was found to be similar to commercially available mouth rinse.

Su Jok therapy by twist and seed method of therapy to reduce the level of fear on COVID-19’s patient: a case series

Patients with COVID-19 not only experience suffering from physiological symptoms but also psychological dimensions such as fear. Fear is part of life and the threat of self-existence will increase the fear level. Increased levels of fear will influence the process of healing by disturbing the immunity function. This case series reports the results of Su Jok therapy using the twist and seed method of therapy in reducing the level of fear of patients with COVID-19. Twenty cases of respondents with the average level of fear toward COVID-19 of ≥4 were included in this case reports. Fear level was measured by using the fear scale measurement (FSM). Su Jok therapy was conducted by twisting (120 times) and putting fenugreek seed on the joint of the patients’ index finger in Triorigin fixed joint correspondent of fear. Posttest of fear scale was measured after intervention in the intervals 5, 10 and 15 minutes. In all three interval measurements, there were significant improvements in the fear scale before and after Su Jok therapy (p=0.0001, p<0.05).

Sustainable adsorption method for the remediation of malachite green dye using nutraceutical industrial fenugreek seed spent

Nutraceutical industrial fenugreek seed spent (NIFGS), a relatively low-cost material abundantly available with nearly negligible toxicity for the bioremediation of malachite green (MG) dye from aqueous media, is reported. Studies on the various parameters affecting the adsorption capacity of NIFGS were carried out to evaluate the kinetics and the equilibrium thermodynamics. All the experiments were designed at about pH 7. The adsorption isotherm model proposed by Langmuir fits better than the Freundlich isotherm model. Kinetic study data confirms the viability of pseudo-second-order model. Calculated thermodynamic factors suggest that the adsorption phenomenon is endothermic, almost instantaneous, and physical in nature.

Sustainable Adsorption Method for the Remediation of Crystal Violet Dye Using Nutraceutical Industrial Fenugreek Seed Spent

Nutraceutical industrial fenugreek seed spent (NIFGS), a relatively low-cost material abundantly available with little toxicity is used in crystal violet (CV) dye remediation from aqueous media and reported in the present study. To access the adsorption capacity, the factors affecting it are kinetics and the equilibrium thermodynamics. All the experiments were designed at approximately pH 7. The adsorption isotherm model proposed by Langmuir fits better than the Freundlich isotherm model. Kinetic studies data confirm the pseudo-second order model. It is evident from thermodynamic parameter values that the process of adsorption is endothermic, physical and dynamic. The process optimization of independent variables that influence adsorption was carried out using response surface methodology (RSM) through bi-level fractional factorial experimental design (FEED). The analysis of variance (ANOVA) was implemented to investigate the combined effect of parameters influencing adsorption. The possibilities of using dye-adsorbed NIFGS (“sludge”) for the fabrication of the composites using plastic waste are suggested.