Excretion, Metabolism, and Pharmacokinetics of 1-(8-(2-Chlorophenyl)-9-(4-Chlorophenyl)-9H-Purin-6-yl)-4-(Ethylamino)Piperidine-4-Carboxamide, a Selective Cannabinoid Receptor Antagonist, in Healthy Male Volunteers

Zhuang Miao; Hao Sun; Jennifer Liras; Chandra Prakash

doi:10.1124/dmd.111.043273

Excretion, Metabolism, and Pharmacokinetics of 1-(8-(2-Chlorophenyl)-9-(4-Chlorophenyl)-9H-Purin-6-yl)-4-(Ethylamino)Piperidine-4-Carboxamide, a Selective Cannabinoid Receptor Antagonist, in Healthy Male Volunteers

Drug Metabolism and Disposition ◽

10.1124/dmd.111.043273 ◽

2011 ◽

Vol 40 (3) ◽

pp. 568-578 ◽

Cited By ~ 6

Author(s):

Zhuang Miao ◽

Hao Sun ◽

Jennifer Liras ◽

Chandra Prakash

Keyword(s):

Receptor Antagonist ◽

Cannabinoid Receptor ◽

Healthy Male ◽

Healthy Male Volunteers ◽

Male Volunteers

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1244 The pharmacokinetic effect of the specific ETA receptor antagonist zibotentan (ZD4054) on CYP3A4 activity using midazolam as a probe in healthy male volunteers

European Journal of Cancer Supplements ◽

10.1016/s1359-6349(09)70456-2 ◽

2009 ◽

Vol 7 (2) ◽

pp. 133-134

Author(s):

J. Kemp ◽

H.K. Tomkinson ◽

D. Mazur ◽

T. Wollseifen ◽

T. Morris ◽

...

Keyword(s):

Receptor Antagonist ◽

Cyp3a4 Activity ◽

Healthy Male ◽

Healthy Male Volunteers ◽

Male Volunteers ◽

Eta Receptor ◽

Eta Receptor Antagonist

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In vitrometabolism of the specific endothelin-A receptor antagonist ZD4054 and clinical drug interactions between ZD4054 and rifampicin or itraconazole in healthy male volunteers

Xenobiotica ◽

10.1080/00498250902810944 ◽

2009 ◽

Vol 39 (6) ◽

pp. 444-456 ◽

Cited By ~ 7

Author(s):

H. C. Swaisland ◽

S. D. Oliver ◽

T. Morris ◽

H. K. Jones ◽

A. Bakhtyari ◽

...

Keyword(s):

Drug Interactions ◽

Receptor Antagonist ◽

Healthy Male ◽

Healthy Male Volunteers ◽

Male Volunteers ◽

Endothelin A Receptor ◽

Endothelin A ◽

Clinical Drug

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A novel prostanoid EP1 receptor antagonist, ONO-8539, reduces acid-induced heartburn symptoms in healthy male volunteers: a randomized clinical trial

Journal of Gastroenterology ◽

10.1007/s00535-017-1308-3 ◽

2017 ◽

Vol 52 (10) ◽

pp. 1081-1089 ◽

Cited By ~ 4

Author(s):

Takashi Kondo ◽

Hiroo Sei ◽

Takahisa Yamasaki ◽

Toshihiko Tomita ◽

Yoshio Ohda ◽

...

Keyword(s):

Clinical Trial ◽

Receptor Antagonist ◽

Randomized Clinical Trial ◽

Healthy Male ◽

Healthy Male Volunteers ◽

Male Volunteers ◽

Ep1 Receptor

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Effects of ZK 93 426, a β-carboline benzodiazepine receptor antagonist on night sleep pattern in healthy male volunteers

Psychopharmacology ◽

10.1007/bf02245185 ◽

1995 ◽

Vol 117 (2) ◽

pp. 178-185 ◽

Cited By ~ 1

Author(s):

T. Duka ◽

D. Goerke ◽

K. Fichte

Keyword(s):

Receptor Antagonist ◽

Benzodiazepine Receptor ◽

Sleep Pattern ◽

Healthy Male ◽

Night Sleep ◽

Healthy Male Volunteers ◽

Male Volunteers ◽

Zk 93 426 ◽

Benzodiazepine Receptor Antagonist

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Multiple-Dose Pharmacokinetics, Safety, and Tolerability of Bosentan, an Endothelin Receptor Antagonist, in Healthy Male Volunteers

The Journal of Clinical Pharmacology ◽

10.1177/00912709922008344 ◽

1999 ◽

Vol 39 (7) ◽

pp. 703-714 ◽

Cited By ~ 65

Author(s):

Cornelia Weber ◽

Rita Schmitt ◽

Herbert Birnboeck ◽

Gerard Hopfgartner ◽

Herwig Eggers ◽

...

Keyword(s):

Receptor Antagonist ◽

Multiple Dose ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Healthy Male ◽

Healthy Male Volunteers ◽

Male Volunteers ◽

Multiple Dose Pharmacokinetics

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Evening dosing is associated with higher plasma concentrations of pranlukast, a leukotriene receptor antagonist, in healthy male volunteers

British Journal of Clinical Pharmacology ◽

10.1046/j.1365-2125.1997.00650.x ◽

1997 ◽

Vol 44 (3) ◽

pp. 289-291 ◽

Cited By ~ 13

Author(s):

Dion R. Brocks ◽

James Upward ◽

Maria Davy ◽

Kate Howland ◽

Christopher Compton ◽

...

Keyword(s):

Receptor Antagonist ◽

Plasma Concentrations ◽

Healthy Male ◽

Leukotriene Receptor Antagonist ◽

Healthy Male Volunteers ◽

Male Volunteers ◽

Leukotriene Receptor

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700 FIRST‐IN‐HUMAN (FIH) STUDY IN HEALTHY MALE VOLUNTEERS OF A NEW SELECTIVE SIGMA‐1 RECEPTOR ANTAGONIST (S1RA)

European Journal of Pain ◽

10.1016/s1090-3801(09)60703-5 ◽

2009 ◽

Vol 13 (S1) ◽

Author(s):

M. Abadias ◽

M. Escriche ◽

E. Ortiz ◽

S. Casals ◽

Z. Xu ◽

...

Keyword(s):

Receptor Antagonist ◽

Healthy Male ◽

Sigma 1 Receptor ◽

Healthy Male Volunteers ◽

Male Volunteers ◽

Sigma 1

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Metabolism, Pharmacokinetics, and Excretion of a Nonpeptidic Substance P Receptor Antagonist, Ezlopitant, in Normal Healthy Male Volunteers: Characterization of Polar Metabolites by Chemical Derivatization with Dansyl Chloride

Drug Metabolism and Disposition ◽

10.1124/dmd.107.015362 ◽

2007 ◽

Vol 35 (7) ◽

pp. 1071-1080 ◽

Cited By ~ 8

Author(s):

Chandra Prakash ◽

John O'Donnell ◽

S. Cyrus Khojasteh-Bakht

Keyword(s):

Substance P ◽

Receptor Antagonist ◽

Dansyl Chloride ◽

Chemical Derivatization ◽

Healthy Male ◽

Healthy Male Volunteers ◽

Male Volunteers ◽

Polar Metabolites ◽

Substance P Receptor

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Glucocorticoid treatment is associated with dose-dependent insulin resistance in healthy male volunteers

Endocrine Abstracts ◽

10.1530/endoabs.67.o55 ◽

2019 ◽

Author(s):

Riccardo Pofi ◽

Ilaria Bonaventura ◽

Nanthia Othonos ◽

Thomas Marjot ◽

Ahmed Moolla ◽

...

Keyword(s):

Insulin Resistance ◽

Healthy Male ◽

Glucocorticoid Treatment ◽

Healthy Male Volunteers ◽

Male Volunteers ◽

Dose Dependent

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Pharmacokinetics of HCP1305 and Co-administration of HCP0605, HGP0816 in Healthy Male Volunteers

Case Medical Research ◽

10.31525/ct1-nct04039724 ◽

2019 ◽

Author(s):

Keyword(s):

Healthy Male ◽

Healthy Male Volunteers ◽

Male Volunteers

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