Determination of Human Hepatocyte Intrinsic Clearance for Slowly Metabolized Compounds: Comparison of a Primary Hepatocyte/Stromal Cell Co-culture with Plated Primary Hepatocytes and HepaRG

B. Bonn; P. Svanberg; A. Janefeldt; I. Hultman; K. Grime

doi:10.1124/dmd.115.067769

Determination of Human Hepatocyte Intrinsic Clearance for Slowly Metabolized Compounds: Comparison of a Primary Hepatocyte/Stromal Cell Co-culture with Plated Primary Hepatocytes and HepaRG

Drug Metabolism and Disposition ◽

10.1124/dmd.115.067769 ◽

2016 ◽

Vol 44 (4) ◽

pp. 527-533 ◽

Cited By ~ 36

Author(s):

B. Bonn ◽

P. Svanberg ◽

A. Janefeldt ◽

I. Hultman ◽

K. Grime

Keyword(s):

Stromal Cell ◽

Intrinsic Clearance ◽

Human Hepatocyte ◽

Primary Hepatocyte ◽

Primary Hepatocytes

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Determination of low intrinsic clearance in vitro: the benefit of a novel internal standard in human hepatocyte incubations

Xenobiotica ◽

10.1080/00498254.2018.1451010 ◽

2018 ◽

Vol 49 (4) ◽

pp. 381-387 ◽

Cited By ~ 2

Author(s):

Ugo Zanelli ◽

Thomas Michna ◽

Carl Petersson

Keyword(s):

Internal Standard ◽

Intrinsic Clearance ◽

Human Hepatocyte

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Development and Characterization of a Human Hepatocyte Low Intrinsic Clearance Assay for Use in Drug Discovery

Drug Metabolism and Disposition ◽

10.1124/dmd.118.081596 ◽

2018 ◽

Vol 46 (8) ◽

pp. 1169-1178 ◽

Cited By ~ 8

Author(s):

Paul Lancett ◽

Beth Williamson ◽

Patrick Barton ◽

Robert J. Riley

Keyword(s):

Drug Discovery ◽

Intrinsic Clearance ◽

Human Hepatocyte

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P163 - Determination of intrinsic clearance of low turnover drugs using HuREL hepatocyte co-cultures

Drug Metabolism and Pharmacokinetics ◽

10.1016/j.dmpk.2020.04.164 ◽

2020 ◽

Vol 35 (1) ◽

pp. S72-S73

Author(s):

Anantha Ram Nookala ◽

Michael Fitzsimmons ◽

Daniel Albaugh ◽

Donald L. McKenzie ◽

Gang Luo

Keyword(s):

Intrinsic Clearance

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Interlaboratory Variability in Human Hepatocyte Intrinsic Clearance Values and Trends with Physicochemical Properties

Pharmaceutical Research ◽

10.1007/s11095-019-2645-0 ◽

2019 ◽

Vol 36 (8) ◽

Cited By ~ 3

Author(s):

Christine M. Bowman ◽

Leslie Z. Benet

Keyword(s):

Physicochemical Properties ◽

Intrinsic Clearance ◽

Human Hepatocyte ◽

Interlaboratory Variability

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Xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss): Determination of trout hepatocellularity, optimization of cell concentrations and comparison of serum and serum-free incubations

Aquatic Toxicology ◽

10.1016/j.aquatox.2008.05.010 ◽

2008 ◽

Vol 89 (1) ◽

pp. 11-17 ◽

Cited By ~ 10

Author(s):

Xing Han ◽

Robert T. Mingoia ◽

Diane L. Nabb ◽

Ching-Hui Yang ◽

Suzanne I. Snajdr ◽

...

Keyword(s):

Rainbow Trout ◽

Oncorhynchus Mykiss ◽

Isolated Hepatocytes ◽

Intrinsic Clearance ◽

Serum Free ◽

Rainbow Trout Oncorhynchus Mykiss ◽

Cell Concentrations

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Determination of Fatty Acid Oxidation and Lipogenesis in Mouse Primary Hepatocytes

Journal of Visualized Experiments ◽

10.3791/52982 ◽

2015 ◽

Cited By ~ 3

Author(s):

Thomas E. Akie ◽

Marcus P. Cooper

Keyword(s):

Fatty Acid ◽

Fatty Acid Oxidation ◽

Acid Oxidation ◽

Primary Hepatocytes

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LIVER MICROSOMES AND S9 FROM RAINBOW TROUT (ONCORHYNCHUS MYKISS): COMPARISON OF BASAL-LEVEL ENZYME ACTIVITIES WITH RAT AND DETERMINATION OF XENOBIOTIC INTRINSIC CLEARANCE IN SUPPORT OF BIOACCUMULATION ASSESSMENT

Environmental Toxicology and Chemistry ◽

10.1897/08-269.1 ◽

2009 ◽

Vol 28 (3) ◽

pp. 481 ◽

Cited By ~ 42

Author(s):

Xing Han ◽

Diane L. Nabb ◽

Ching-Hui Yang ◽

Suzanne I. Snajdr ◽

Robert T. Mingoia

Keyword(s):

Rainbow Trout ◽

Oncorhynchus Mykiss ◽

Enzyme Activities ◽

Liver Microsomes ◽

Intrinsic Clearance ◽

Rainbow Trout Oncorhynchus Mykiss

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Primary human hepatocyte cultures as a tool for determination of neutralizing activity of antibodies against different hepatitis B virus isolates

Zeitschrift für Gastroenterologie ◽

10.1055/s-2004-816184 ◽

2004 ◽

Vol 42 (01) ◽

Author(s):

S Boehm ◽

UC Tausch ◽

E Roehrl ◽

WE Thasler ◽

T Weiß ◽

...

Keyword(s):

Hepatitis B Virus ◽

Hepatitis B ◽

Human Hepatocyte ◽

Neutralizing Activity ◽

Hepatocyte Cultures ◽

Primary Human Hepatocyte ◽

B Virus ◽

Virus Isolates

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Further Assessment of the Relay Hepatocyte Assay for Determination of Intrinsic Clearance of Slowly Metabolised Compounds Using Radioactivity Monitoring and LC–MS Methods

European Journal of Drug Metabolism and Pharmacokinetics ◽

10.1007/s13318-019-00571-x ◽

2019 ◽

Vol 44 (6) ◽

pp. 817-826 ◽

Cited By ~ 1

Author(s):

Renata Murgasova

Keyword(s):

Intrinsic Clearance ◽

Radioactivity Monitoring

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Determination of a Degradation Constant for CYP3A4 by Direct Suppression of mRNA in a Novel Human Hepatocyte Model, HepatoPac

Drug Metabolism and Disposition ◽

10.1124/dmd.115.065326 ◽

2015 ◽

Vol 43 (9) ◽

pp. 1307-1315 ◽

Cited By ~ 20

Author(s):

Diane Ramsden ◽

Jin Zhou ◽

Donald J. Tweedie

Keyword(s):

Human Hepatocyte ◽

Direct Suppression

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