Deconvolution of CYP Induction Mechanisms in HepaRG Nuclear Hormone Receptor Knockout Cells

2021 ◽  
pp. DMD-AR-2020-000333
Author(s):  
Lena C. Preiss ◽  
Ruoqi Liu ◽  
Philip Hewitt ◽  
David Thompson ◽  
Katrin Georgi ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Nuclear Hormone Receptor ◽  
Cyp Induction

scholarly journals Phosphorylation of the Hinge Domain of the Nuclear Hormone Receptor LRH-1 Stimulates Transactivation

2006 ◽  
Vol 281 (12) ◽  
pp. 7850-7855 ◽  
Author(s):  
Yoon-Kwang Lee ◽  
Yun-Hee Choi ◽  
Steven Chua ◽  
Young Joo Park ◽  
David D. Moore
Keyword(s):  
Hormone Receptor ◽  
Nuclear Hormone Receptor ◽  
Hinge Domain

scholarly journals Pseudoginsenoside F11, a Novel Partial PPARγAgonist, Promotes Adiponectin Oligomerization and Secretion in 3T3-L1 Adipocytes

PPAR Research ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Guoyu Wu ◽  
Junyang Yi ◽  
Ling Liu ◽  
Pengcheng Wang ◽  
Zhijie Zhang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Side Effects ◽  
Hormone Receptor ◽  
Adipocyte Differentiation ◽  
American Ginseng ◽  
Nuclear Hormone Receptor ◽  
Targeted Therapeutics ◽  
Panax Quinquefolium ◽  
Master Regulator

PPARγis a nuclear hormone receptor that functions as a master regulator of adipocyte differentiation and development. Full PPARγagonists, such as the thiazolidinediones (TZDs), have been widely used to treat type 2 diabetes. However, they are characterized by undesirable side effects due to their strong agonist activities. Pseudoginsenoside F11 (p-F11) is an ocotillol-type ginsenoside isolated fromPanax quinquefolium L.(American ginseng). In this study, we found that p-F11 activates PPARγwith modest adipogenic activity. In addition, p-F11 promotes adiponectin oligomerization and secretion in 3T3-L1 adipocytes. We also found that p-F11 inhibits obesity-linked phosphorylation of PPARγat Ser-273 by Cdk5. Therefore, p-F11 is a novel partial PPARγagonist, which might have the potential to be developed as a new PPARγ-targeted therapeutics for type 2 diabetes.

Inhibition of nuclear hormone receptor activity by calreticulin

Nature ◽  
1994 ◽  
Vol 367 (6462) ◽  
pp. 480-483 ◽  
Author(s):  
Shoukat Dedhar ◽  
Paul S. Rennie ◽  
Mary Shago ◽  
Chung-Yee Leung Hagesteijn ◽  
Huiling Yang ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Nuclear Hormone Receptor ◽  
Receptor Activity

scholarly journals Nuclear Hormone Receptor Coregulator GRIP1 Suppresses, whereas SRC1A and p/CIP Coactivate, by Domain-specific Binding of MyoD

2004 ◽  
Vol 280 (5) ◽  
pp. 3129-3137 ◽  
Author(s):  
Hung-Yi Wu ◽  
Yasuo Hamamori ◽  
Jianming Xu ◽  
Shin C. Chang ◽  
Terry Saluna ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Specific Binding ◽  
Nuclear Hormone Receptor ◽  
Domain Specific
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