Selective Nonsteroidal Anti-Inflammatory Drugs Induce Thymosin β-4 and Alter Actin Cytoskeletal Organization in Human Colorectal Cancer Cells

2004 ◽  
Vol 311 (3) ◽  
pp. 885-891 ◽  
Author(s):  
Anshu K. Jain ◽  
Scott M. Moore ◽  
Kiyoshi Yamaguchi ◽  
Thomas E. Eling ◽  
Seung Joon Baek
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Human Colorectal Cancer ◽  
Cytoskeletal Organization ◽  
Colorectal Cancer Cells ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Human Colorectal Cancer Cells

scholarly journals Expression of NUANCE, a potential novel oncogene, is inhibited by nonsteroidal anti‐inflammatory drugs (NSAIDs) in human colorectal cancer cells

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Jason Lee Liggett ◽  
Chang Kyoung Choi ◽  
Robert L Donnell ◽  
Anthony E English ◽  
Kenneth David Kihm ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Human Colorectal Cancer Cells

scholarly journals Anti-inflammatory effect of lycopene in SW480 human colorectal cancer cells

2017 ◽  
Vol 11 (2) ◽  
pp. 90 ◽  
Author(s):  
Jae Hoon Cha ◽  
Woo Kyoung Kim ◽  
Ae Wha Ha ◽  
Myung Hwan Kim ◽  
Moon Jeong Chang
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Anti Inflammatory ◽  
Human Colorectal Cancer Cells ◽  
Inflammatory Effect

scholarly journals Polyamines reverse non-steroidal anti-inflammatory drug-induced toxicity in human colorectal cancer cells

2003 ◽  
Vol 374 (2) ◽  
pp. 481-488 ◽  
Author(s):  
Alun HUGHES ◽  
Nicholas I. SMITH ◽  
Heather M. WALLACE
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Cell Number ◽  
Human Colorectal Cancer ◽  
Morphological Examination ◽  
Drug Induced ◽  
Colorectal Cancer Cells ◽  
Polyamine Content ◽  
Anti Inflammatory ◽  
Human Colorectal Cancer Cells

Naproxen, sulindac and salicylate, three NSAIDs (non-steroidal anti-inflammatory drugs), were cytotoxic to human colorectal cancer cells in culture. Toxicity was accompanied by significant depletion of intracellular polyamine content. Inhibition of ornithine decarboxylase (the first enzyme of the polyamine biosynthetic pathway), induction of polyamine oxidase and spermidine/spermine N1-acetyltransferase (the enzymes responsible for polyamine catabolism) and induction of polyamine export all contributed to the decreased intracellular polyamine content. Morphological examination of the cells showed typical signs of apoptosis, and this was confirmed by DNA fragmentation and measurement of caspase-3-like activity. Re-addition of spermidine to the cells partially prevented apoptosis and recovered the cell number. Thus polyamines appear to be an integral part of the signalling pathway mediating NSAID toxicity in human colorectal cancer cells, and may therefore also be important in cancer chemoprevention in humans.

Role of nonsteroidal anti-inflammatory drug-activated gene-1 in docetaxel-induced cell death of human colorectal cancer cells with different p53 status

2011 ◽  
Vol 34 (2) ◽  
pp. 323-330 ◽  
Author(s):  
Il-Yeob Kim ◽  
Su-Young Park ◽  
Youra Kang ◽  
Dinesh Thapa ◽  
Han Gon Choi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Human Colorectal Cancer ◽  
Inflammatory Drug ◽  
Colorectal Cancer Cells ◽  
P53 Status ◽  
Anti Inflammatory ◽  
Human Colorectal Cancer Cells
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