The Inactivation of Cytochrome P450 3A5 by 17α-Ethynylestradiol Is Cytochrome b5-Dependent: Metabolic Activation of the Ethynyl Moiety Leads to the Formation of Glutathione Conjugates, a Heme Adduct, and Covalent Binding to the Apoprotein

Hsia-lien Lin; Paul F. Hollenberg

doi:10.1124/jpet.106.117861

The Inactivation of Cytochrome P450 3A5 by 17α-Ethynylestradiol Is Cytochrome b5-Dependent: Metabolic Activation of the Ethynyl Moiety Leads to the Formation of Glutathione Conjugates, a Heme Adduct, and Covalent Binding to the Apoprotein

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.106.117861 ◽

2007 ◽

Vol 321 (1) ◽

pp. 276-287 ◽

Cited By ~ 24

Author(s):

Hsia-lien Lin ◽

Paul F. Hollenberg

Keyword(s):

Cytochrome P450 ◽

Covalent Binding ◽

Cytochrome B5 ◽

Metabolic Activation ◽

Glutathione Conjugates ◽

Cytochrome P450 3A5

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Biphasic effects of the flavonoids quercetin and naringenin on the metabolic activation of 2-amino-3,5-dimethylimidazo[4,5-f]quinoline by Salmonella typhimurium TA1538 co-expressing human cytochrome P450 1A2, NADPH-cytochrome P450 reductase, and cytochrome b5

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis ◽

10.1016/j.mrfmmm.2003.08.002 ◽

2004 ◽

Vol 545 (1-2) ◽

pp. 37-47 ◽

Cited By ~ 21

Author(s):

I Kang

Keyword(s):

Cytochrome P450 ◽

Salmonella Typhimurium ◽

Cytochrome B5 ◽

Metabolic Activation ◽

Cytochrome P450 Reductase ◽

Cytochrome P450 1A2 ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Human Cytochrome ◽

Nadph Cytochrome P450 Reductase

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Cytochrome b5 Increases Cytochrome P450 3A4-Mediated Activation of Anticancer Drug Ellipticine to 13-Hydroxyellipticine Whose Covalent Binding to DNA Is Elevated by Sulfotransferases and N,O-Acetyltransferases

Chemical Research in Toxicology ◽

10.1021/tx3000335 ◽

2012 ◽

Vol 25 (5) ◽

pp. 1075-1085 ◽

Cited By ~ 24

Author(s):

Marie Stiborová ◽

Radek Indra ◽

Michaela Moserová ◽

Věra Černá ◽

Martina Rupertová ◽

...

Keyword(s):

Cytochrome P450 ◽

Anticancer Drug ◽

Covalent Binding ◽

Cytochrome B5 ◽

Cytochrome P450 3A4

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A near-infrared ratiometric fluorescent probe for selectively tracking human cytochrome P450 3A5 in living cells and tumor-bearing mice

Sensors and Actuators B Chemical ◽

10.1016/j.snb.2020.129372 ◽

2021 ◽

Vol 331 ◽

pp. 129372

Author(s):

Hefang Ji ◽

Fulong Ma ◽

Yanpeng Dai ◽

Xinxin Zhao ◽

Ke Xue ◽

...

Keyword(s):

Cytochrome P450 ◽

Fluorescent Probe ◽

Near Infrared ◽

Living Cells ◽

Tumor Bearing ◽

Human Cytochrome ◽

Cytochrome P450 3A5 ◽

Ratiometric Fluorescent Probe

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Effect of cytochrome P450 3A5 polymorphism on platelet reactivity after treatment with clopidogrel in patients scheduled for percutaneous coronary intervention

The Egyptian Heart Journal ◽

10.1016/j.ehj.2011.08.025 ◽

2011 ◽

Vol 63 (1) ◽

pp. 23-31 ◽

Cited By ~ 1

Author(s):

Abeer A. Saad ◽

Ahmed M. Abd Elsalam ◽

Gihan M. Kamal ◽

Nahla F. Abou El-Ezz ◽

Rehab S. El-Hagracy

Keyword(s):

Percutaneous Coronary Intervention ◽

Cytochrome P450 ◽

Platelet Reactivity ◽

Coronary Intervention ◽

Percutaneous Coronary ◽

Cytochrome P450 3A5

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Role of metabolic activation by cytochrome P450 in thioacetamide-induced suppression of antibody response in male BALB/c mice

Toxicology Letters ◽

10.1016/s0378-4274(00)00168-5 ◽

2000 ◽

Vol 114 (1-3) ◽

pp. 225-235 ◽

Cited By ~ 14

Author(s):

Kap-Ho Kim ◽

Ju-Hyun Bae ◽

Shin-Woo Cha ◽

Sang-Seop Han ◽

Kwan Ha Park ◽

...

Keyword(s):

Cytochrome P450 ◽

Antibody Response ◽

Metabolic Activation

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NADH:cytochrome b5 reductase and cytochrome b5 act as sole electron donors to human cytochrome P450 1A1-catalyzed oxidation and DNA adduct formation by benzo[a]pyrene

Toxicology Letters ◽

10.1016/j.toxlet.2016.06.1417 ◽

2016 ◽

Vol 258 ◽

pp. S96

Author(s):

M. Stiborova ◽

I. Radek ◽

M. Moserova ◽

E. Frei ◽

K. Kopka ◽

...

Keyword(s):

Cytochrome P450 ◽

Cytochrome B5 ◽

Adduct Formation ◽

Dna Adduct ◽

Electron Donors ◽

Cytochrome P450 1A1 ◽

Human Cytochrome ◽

Catalyzed Oxidation

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Evidence That Cytochrome b5 and Cytochrome b5 Reductase Can Act as Sole Electron Donors to the Hepatic Cytochrome P450 System

Molecular Pharmacology ◽

10.1124/mol.112.084616 ◽

2013 ◽

Vol 83 (6) ◽

pp. 1209-1217 ◽

Cited By ~ 38

Author(s):

Colin J. Henderson ◽

Lesley A. McLaughlin ◽

C. Roland Wolf

Keyword(s):

Cytochrome P450 ◽

Cytochrome B5 ◽

Electron Donors ◽

Cytochrome P450 System ◽

Cytochrome B5 Reductase ◽

Hepatic Cytochrome

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Functional Aspects of Protein-Protein Interactions of Cytochrome P450 Cytochrome b5 and Cytochrome P450 Reductase

Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds ◽

10.1007/978-1-4684-7284-4_11 ◽

1991 ◽

pp. 185-198 ◽

Cited By ~ 1

Author(s):

John B. Schenkman

Keyword(s):

Cytochrome P450 ◽

Protein Interactions ◽

Cytochrome B5 ◽

Cytochrome P450 Reductase ◽

Protein Protein Interactions ◽

P450 Reductase ◽

Functional Aspects

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Chromatographic separation and behavior of microsomal cytochrome P450 and cytochrome b5

Journal of Chromatography B Biomedical Sciences and Applications ◽

10.1016/0378-4347(96)00018-7 ◽

1996 ◽

Vol 684 (1-2) ◽

pp. 107-131 ◽

Cited By ~ 18

Author(s):

Peter H. Roos

Keyword(s):

Cytochrome P450 ◽

Chromatographic Separation ◽

Cytochrome B5 ◽

Microsomal Cytochrome ◽

Microsomal Cytochrome P450 ◽

And Behavior

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Reduction of cytochrome b5 by NADPH–cytochrome P450 reductase

Archives of Biochemistry and Biophysics ◽

10.1016/j.abb.2005.06.019 ◽

2005 ◽

Vol 440 (2) ◽

pp. 204-211 ◽

Cited By ~ 56

Author(s):

F. Peter Guengerich

Keyword(s):

Cytochrome P450 ◽

Cytochrome B5 ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Nadph Cytochrome P450 Reductase

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