Spleen Tyrosine Kinase Mediates BEAS-2B Cell Migration and Proliferation and Human Rhinovirus-Induced Expression of Vascular Endothelial Growth Factor and Interleukin-8

2011 ◽  
Vol 340 (2) ◽  
pp. 277-285 ◽  
Author(s):  
Xiaomin Wang ◽  
Mirek Mychajlowycz ◽  
Christine Lau ◽  
Carlos Gutierrez ◽  
Jeremy A. Scott ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Cell Migration ◽  
Growth Factor ◽  
Tyrosine Kinase ◽  
Interleukin 8 ◽  
Vascular Endothelial ◽  
Spleen Tyrosine Kinase ◽  
Induced Expression ◽  
Cell Migration And Proliferation ◽  
Endothelial Growth Factor

Cell migration and growth induced by photo-immobilised vascular endothelial growth factor (VEGF) isoforms

2019 ◽  
Vol 7 (27) ◽  
pp. 4272-4279 ◽  
Author(s):  
Xueli Ren ◽  
Jun Akimoto ◽  
Hideyuki Miyatake ◽  
Seiichi Tada ◽  
Liping Zhu ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Cell Migration ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Cell Migration And Proliferation ◽  
Endothelial Growth Factor ◽  
Vegf Isoforms

VEGF isoforms immobilised by photo-reactive gelatin (AzPhe-gelatin) enhance cell migration and proliferation.

scholarly journals Spleen tyrosine kinase mediates angiotensin II‐ and vascular endothelial growth factor‐induced angiogenesis

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Cuneyt Kemal Buharalioglu ◽  
Fariborz A Yaghini ◽  
Chi Young Song ◽  
Hafiz U Ghafoor ◽  
Anne M Estes ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Angiotensin Ii ◽  
Growth Factor ◽  
Tyrosine Kinase ◽  
Vascular Endothelial ◽  
Spleen Tyrosine Kinase ◽  
Endothelial Growth Factor

scholarly journals Phosphorylation of Focal Adhesion Kinase (FAK) on Ser732 Is Induced by Rho-dependent Kinase and Is Essential for Proline-rich Tyrosine Kinase-2–mediated Phosphorylation of FAK on Tyr407 in Response to Vascular Endothelial Growth Factor

2006 ◽  
Vol 17 (8) ◽  
pp. 3508-3520 ◽  
Author(s):  
Fabrice Le Boeuf ◽  
François Houle ◽  
Mark Sussman ◽  
Jacques Huot
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Cell Migration ◽  
Growth Factor ◽  
Tyrosine Kinase ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Endothelial Cell Migration ◽  
Vascular Endothelial ◽  
Tyrosine Kinase 2 ◽  
Endothelial Growth Factor

Focal adhesion kinase (FAK) is phosphorylated on tyrosine and serine residues after cell activation. In the present work, we investigated the relationship between tyrosine and serine phosphorylation of FAK in promoting endothelial cell migration in response to vascular endothelial growth factor (VEGF). We found that VEGF induces the activation of the Rho-dependent kinase (ROCK) downstream from vascular endothelial growth factor receptor (VEGFR) 2. In turn, activated ROCK directly phosphorylates FAK on Ser732. Proline-rich tyrosine kinase-2 (Pyk2) is also activated in response to VEGF. Its activation requires the clustering of integrin αvβ3 and triggers directly the phosphorylation of Tyr407 within FAK, an event necessary for cell migration. Interestingly, ROCK-mediated phosphorylation of Ser732 is essential for Pyk2-dependent phosphorylation of Tyr407, because the latter is abrogated in cells expressing a FAK mutant that is nonphosphorylatable on Ser732. We suggest that VEGF elicits the activation of the VEGFR2–ROCK pathway, leading to phosphorylation of Ser732 within FAK. In turn, phosphorylation of Ser732 would change the conformation of FAK, making it accessible to Pyk2 activated in response to its association with integrin β3. Then, activated Pyk2 triggers the phosphorylation of FAK on Tyr407, promoting cell migration.

Bleeding with vascular endothelial growth factor tyrosine kinase inhibitor: A network meta-analysis

2021 ◽  
Vol 157 ◽  
pp. 103186
Author(s):  
Avash Das ◽  
Somnath Mahapatra ◽  
Dhrubajyoti Bandyopadhyay ◽  
Santanu Samanta ◽  
Sandipan Chakraborty ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Kinase Inhibitor ◽  
Meta Analysis ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor

Science ◽  
1992 ◽  
Vol 255 (5047) ◽  
pp. 989-991 ◽  
Author(s):  
C de Vries ◽  
J. Escobedo ◽  
H Ueno ◽  
K Houck ◽  
N Ferrara ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Tyrosine Kinase ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor ◽  
Kinase A

Inhibition of endothelial cell migration and angiogenesis by a vascular endothelial growth factor receptor-1 derived peptide

2008 ◽  
Vol 44 (13) ◽  
pp. 1914-1921 ◽  
Author(s):  
Pedro M. Lacal ◽  
Veronica Morea ◽  
Federica Ruffini ◽  
Angela Orecchia ◽  
Annalisa S. Dorio ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Cell Migration ◽  
Endothelial Cell ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Endothelial Cell Migration ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor
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