Cell migration and growth induced by photo-immobilised vascular endothelial growth factor (VEGF) isoforms

2019 ◽  
Vol 7 (27) ◽  
pp. 4272-4279 ◽  
Author(s):  
Xueli Ren ◽  
Jun Akimoto ◽  
Hideyuki Miyatake ◽  
Seiichi Tada ◽  
Liping Zhu ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Cell Migration ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Cell Migration And Proliferation ◽  
Endothelial Growth Factor ◽  
Vegf Isoforms

VEGF isoforms immobilised by photo-reactive gelatin (AzPhe-gelatin) enhance cell migration and proliferation.

scholarly journals Matrix-Binding Vascular Endothelial Growth Factor (VEGF) Isoforms Guide Granule Cell Migration in the Cerebellum via VEGF Receptor Flk1

2010 ◽  
Vol 30 (45) ◽  
pp. 15052-15066 ◽  
Author(s):  
C. Ruiz de Almodovar ◽  
C. Coulon ◽  
P. A. Salin ◽  
E. Knevels ◽  
N. Chounlamountri ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Cell Migration ◽  
Growth Factor ◽  
Granule Cell ◽  
Vegf Receptor ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor ◽  
Vegf Isoforms

Inhibition of endothelial cell migration and angiogenesis by a vascular endothelial growth factor receptor-1 derived peptide

2008 ◽  
Vol 44 (13) ◽  
pp. 1914-1921 ◽  
Author(s):  
Pedro M. Lacal ◽  
Veronica Morea ◽  
Federica Ruffini ◽  
Angela Orecchia ◽  
Annalisa S. Dorio ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Cell Migration ◽  
Endothelial Cell ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Endothelial Cell Migration ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

scholarly journals Caveolin-1 Is Required for Vascular Endothelial Growth Factor-Triggered Multiple Myeloma Cell Migration and Is Targeted by Bortezomib

2004 ◽  
Vol 64 (20) ◽  
pp. 7500-7506 ◽  
Author(s):  
Klaus Podar ◽  
Reshma Shringarpure ◽  
Yu-Tzu Tai ◽  
Melissa Simoncini ◽  
Martin Sattler ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Vascular Endothelial Growth Factor ◽  
Cell Migration ◽  
Growth Factor ◽  
Myeloma Cell ◽  
Vascular Endothelial ◽  
Caveolin 1 ◽  
Multiple Myeloma Cell ◽  
Endothelial Growth Factor

scholarly journals Expression of Vascular Endothelial Growth Factor (VEGF) Isoforms VEGFxxxb in Normal Human Renal Development

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Heather Samantha Bevan ◽  
Nynke N.M.S van den Akker ◽  
Japke A.E Polman ◽  
Steve J Harper ◽  
Adriana C Gittenberger‐de Groot ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Renal Development ◽  
Vascular Endothelial ◽  
Normal Human ◽  
Endothelial Growth Factor ◽  
Vegf Isoforms

scholarly journals The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.

1993 ◽  
Vol 4 (12) ◽  
pp. 1317-1326 ◽  
Author(s):  
J E Park ◽  
G A Keller ◽  
N Ferrara
Keyword(s):  
Extracellular Matrix ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Vegf Mrna ◽  
Angiogenic Potential ◽  
Molecular Masses ◽  
Matrix Bound ◽  
Endothelial Growth Factor ◽  
Vegf Isoforms

Vascular endothelial growth factor (VEGF)mRNA undergoes alternative splicing events that generate four different homodimeric isoforms, VEGF121, VEGF165, VEGF189, or VEGF206. VEGF121 is a nonheparin-binding acidic protein, which is freely diffusible. The longer forms, VEGF189 or VEGF206, are highly basic proteins tightly bound to extracellular heparin-containing proteoglycans. VEGF165 has intermediate properties. To determine the localization of VEGF isoforms, transfected human embryonic kidney CEN4 cells expressing VEGF165, VEGF189, or VEGF206 were stained by immunofluorescence with a specific monoclonal antibody. The staining was found in patches and streaks suggestive of extracellular matrix (ECM). VEGF165 was observed largely in Golgi apparatus-like structures. Immunogold labeling of cells expressing VEGF189 or VEGF206 revealed that the staining was localized to the subepithelial ECM. VEGF associated with the ECM was bioactive, because endothelial cells cultured on ECM derived from cells expressing VEGF189 or VEGF206 were markedly stimulated to proliferate. In addition, ECM-bound VEGF can be released into a soluble and bioactive form by heparin or plasmin. ECM-bound VEGF189 and VEGF206 have molecular masses consistent with the intact polypeptides. The ECM may represent an important source of VEGF and angiogenic potential.

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