3β-Methyl-Neurosteroid Analogs Are Preferential Positive Allosteric Modulators and Direct Activators of Extrasynaptic δ-Subunit γ-Aminobutyric Acid Type A Receptors in the Hippocampus Dentate Gyrus Subfield

Shu-Hui Chuang; Doodipala Samba Reddy

doi:10.1124/jpet.117.246660

3β-Methyl-Neurosteroid Analogs Are Preferential Positive Allosteric Modulators and Direct Activators of Extrasynaptic δ-Subunit γ-Aminobutyric Acid Type A Receptors in the Hippocampus Dentate Gyrus Subfield

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.117.246660 ◽

2018 ◽

Vol 365 (3) ◽

pp. 583-601 ◽

Cited By ~ 8

Author(s):

Shu-Hui Chuang ◽

Doodipala Samba Reddy

Keyword(s):

Dentate Gyrus ◽

Type A ◽

Aminobutyric Acid ◽

Allosteric Modulators ◽

Acid Type ◽

Positive Allosteric Modulators

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The efficacy of γ-aminobutyric acid type A receptor (GABA AR) subtype-selective positive allosteric modulators in blocking tetramethylenedisulfotetramine (TETS)-induced seizure-like behavior in larval zebrafish with minimal sedation

Toxicology and Applied Pharmacology ◽

10.1016/j.taap.2021.115643 ◽

2021 ◽

pp. 115643

Author(s):

Paige C. Mundy ◽

Brandon Pressly ◽

Dennis R. Carty ◽

Bianca Yaghoobi ◽

Heike Wulff ◽

...

Keyword(s):

Type A ◽

Aminobutyric Acid ◽

Allosteric Modulators ◽

Larval Zebrafish ◽

Acid Type ◽

Positive Allosteric Modulators ◽

Subtype Selective

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The gamma-aminobutyric acid type A receptor positive allosteric modulators brexanolone injection and SAGE-217 in the treatment of mood disorders: Results from recent placebo-controlled studies

10.1055/s-0039-1679163 ◽

2019 ◽

Author(s):

H Junker ◽

S Kanes ◽

S Meltzer-Brody ◽

H Gunduz-Bruce ◽

A Sankoh ◽

...

Keyword(s):

Mood Disorders ◽

Type A ◽

Aminobutyric Acid ◽

Allosteric Modulators ◽

Gamma Aminobutyric Acid ◽

Acid Type ◽

Positive Allosteric Modulators

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γ-aminobutyric acid type A receptors that contain the δ subunit promote memory and neurogenesis in the dentate gyrus

Annals of Neurology ◽

10.1002/ana.23941 ◽

2013 ◽

Vol 74 (4) ◽

pp. 611-621 ◽

Cited By ~ 23

Author(s):

Paul D. Whissell ◽

Shira Rosenzweig ◽

Irene Lecker ◽

Dian-Shi Wang ◽

J. Martin Wojtowicz ◽

...

Keyword(s):

Dentate Gyrus ◽

Type A ◽

Aminobutyric Acid ◽

Acid Type

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Selective reduction of γ-aminobutyric acid type A receptor δ subunit mRNA levels by MK-801 in rat dentate gyrus

Neuroscience Letters ◽

10.1016/j.neulet.2004.04.022 ◽

2004 ◽

Vol 364 (2) ◽

pp. 106-109 ◽

Cited By ~ 4

Author(s):

Saku T Sinkkonen ◽

Anni-Maija Lindén ◽

Esa R Korpi ◽

Garry Wong

Keyword(s):

Dentate Gyrus ◽

Selective Reduction ◽

Type A ◽

Aminobutyric Acid ◽

Mrna Levels ◽

Mk 801 ◽

Subunit Mrna ◽

Acid Type

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Activation of the γ-Aminobutyric Acid Type B (GABAB) Receptor by Agonists and Positive Allosteric Modulators

Journal of Medicinal Chemistry ◽

10.1021/jm5018913 ◽

2015 ◽

Vol 58 (16) ◽

pp. 6336-6347 ◽

Cited By ~ 21

Author(s):

Katie M. Brown ◽

Kuldeep K. Roy ◽

Gregory H. Hockerman ◽

Robert J. Doerksen ◽

David A. Colby

Keyword(s):

Gabab Receptor ◽

Aminobutyric Acid ◽

Allosteric Modulators ◽

Type B ◽

Acid Type ◽

Positive Allosteric Modulators

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Inhibition of a tonic inhibitory conductance in mouse hippocampal neurones by negative allosteric modulators of α5 subunit-containing γ-aminobutyric acid type A receptors: implications for treating cognitive deficits

British Journal of Anaesthesia ◽

10.1016/j.bja.2020.11.032 ◽

2020 ◽

Author(s):

Marc A. Manzo ◽

Dian-Shi Wang ◽

Winston W. Li ◽

Arsène Pinguelo ◽

Mariana O. Popa ◽

...

Keyword(s):

Cognitive Deficits ◽

Type A ◽

Aminobutyric Acid ◽

Allosteric Modulators ◽

Acid Type ◽

Inhibitory Conductance

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Faculty Opinions recommendation of Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1059787.511720 ◽

2007 ◽

Author(s):

M Bruce MacIver

Keyword(s):

Minimum Alveolar Concentration ◽

Type A ◽

Aminobutyric Acid ◽

Gamma Aminobutyric Acid ◽

Inhaled Anesthetics ◽

Acid Type ◽

Righting Reflex

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Faculty Opinions recommendation of Neurosteroids allosterically modulate binding of the anesthetic etomidate to gamma-aminobutyric acid type A receptors.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1158389.621642 ◽

2009 ◽

Author(s):

Edward Bertaccini

Keyword(s):

Type A ◽

Aminobutyric Acid ◽

Gamma Aminobutyric Acid ◽

Acid Type

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Faculty Opinions recommendation of Inhibition of α5 γ-Aminobutyric acid type A receptors restores recognition memory after general anesthesia.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.14239956.15757056 ◽

2012 ◽

Author(s):

Stan Leung ◽

Tao Luo

Keyword(s):

Recognition Memory ◽

General Anesthesia ◽

Type A ◽

Aminobutyric Acid ◽

Acid Type

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Faculty Opinions recommendation of Anesthetics interfere with axon guidance in developing mouse neocortical neurons in vitro via a γ-aminobutyric acid type A receptor mechanism.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717993480.793477359 ◽

2013 ◽

Author(s):

Vesna Jevtovic-Todorovic

Keyword(s):

Axon Guidance ◽

Type A ◽

Aminobutyric Acid ◽

Neocortical Neurons ◽

Acid Type

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