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Inhibition of a tonic inhibitory conductance in mouse hippocampal neurones by negative allosteric modulators of α5 subunit-containing γ-aminobutyric acid type A receptors: implications for treating cognitive deficits
British Journal of Anaesthesia
◽
10.1016/j.bja.2020.11.032
◽
2020
◽
Author(s):
Marc A. Manzo
◽
Dian-Shi Wang
◽
Winston W. Li
◽
Arsène Pinguelo
◽
Mariana O. Popa
◽
...
Keyword(s):
Cognitive Deficits
◽
Type A
◽
Aminobutyric Acid
◽
Allosteric Modulators
◽
Acid Type
◽
Inhibitory Conductance
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The efficacy of γ-aminobutyric acid type A receptor (GABA AR) subtype-selective positive allosteric modulators in blocking tetramethylenedisulfotetramine (TETS)-induced seizure-like behavior in larval zebrafish with minimal sedation
Toxicology and Applied Pharmacology
◽
10.1016/j.taap.2021.115643
◽
2021
◽
pp. 115643
Author(s):
Paige C. Mundy
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Brandon Pressly
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Dennis R. Carty
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Bianca Yaghoobi
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Heike Wulff
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Keyword(s):
Type A
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Aminobutyric Acid
◽
Allosteric Modulators
◽
Larval Zebrafish
◽
Acid Type
◽
Positive Allosteric Modulators
◽
Subtype Selective
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3β-Methyl-Neurosteroid Analogs Are Preferential Positive Allosteric Modulators and Direct Activators of Extrasynaptic δ-Subunit γ-Aminobutyric Acid Type A Receptors in the Hippocampus Dentate Gyrus Subfield
Journal of Pharmacology and Experimental Therapeutics
◽
10.1124/jpet.117.246660
◽
2018
◽
Vol 365
(3)
◽
pp. 583-601
◽
Cited By ~ 8
Author(s):
Shu-Hui Chuang
◽
Doodipala Samba Reddy
Keyword(s):
Dentate Gyrus
◽
Type A
◽
Aminobutyric Acid
◽
Allosteric Modulators
◽
Acid Type
◽
Positive Allosteric Modulators
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Inhibiting α5 Subunit-Containing γ-Aminobutyric Acid Type A Receptors Attenuates Cognitive Deficits After Traumatic Brain Injury
Critical Care Medicine
◽
10.1097/ccm.0000000000004161
◽
2020
◽
Vol 48
(4)
◽
pp. 533-544
◽
Cited By ~ 1
Author(s):
Shahin Khodaei
◽
Sinziana Avramescu
◽
Dian-Shi Wang
◽
Heping Sheng
◽
Nathan K. Chan
◽
...
Keyword(s):
Traumatic Brain Injury
◽
Brain Injury
◽
Cognitive Deficits
◽
Type A
◽
Aminobutyric Acid
◽
Acid Type
Download Full-text
The gamma-aminobutyric acid type A receptor positive allosteric modulators brexanolone injection and SAGE-217 in the treatment of mood disorders: Results from recent placebo-controlled studies
10.1055/s-0039-1679163
◽
2019
◽
Author(s):
H Junker
◽
S Kanes
◽
S Meltzer-Brody
◽
H Gunduz-Bruce
◽
A Sankoh
◽
...
Keyword(s):
Mood Disorders
◽
Type A
◽
Aminobutyric Acid
◽
Allosteric Modulators
◽
Gamma Aminobutyric Acid
◽
Acid Type
◽
Positive Allosteric Modulators
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Faculty Opinions recommendation of Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.1059787.511720
◽
2007
◽
Author(s):
M Bruce MacIver
Keyword(s):
Minimum Alveolar Concentration
◽
Type A
◽
Aminobutyric Acid
◽
Gamma Aminobutyric Acid
◽
Inhaled Anesthetics
◽
Acid Type
◽
Righting Reflex
Download Full-text
Faculty Opinions recommendation of Neurosteroids allosterically modulate binding of the anesthetic etomidate to gamma-aminobutyric acid type A receptors.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.1158389.621642
◽
2009
◽
Author(s):
Edward Bertaccini
Keyword(s):
Type A
◽
Aminobutyric Acid
◽
Gamma Aminobutyric Acid
◽
Acid Type
Download Full-text
Faculty Opinions recommendation of Inhibition of α5 γ-Aminobutyric acid type A receptors restores recognition memory after general anesthesia.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.14239956.15757056
◽
2012
◽
Author(s):
Stan Leung
◽
Tao Luo
Keyword(s):
Recognition Memory
◽
General Anesthesia
◽
Type A
◽
Aminobutyric Acid
◽
Acid Type
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Faculty Opinions recommendation of Anesthetics interfere with axon guidance in developing mouse neocortical neurons in vitro via a γ-aminobutyric acid type A receptor mechanism.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.717993480.793477359
◽
2013
◽
Author(s):
Vesna Jevtovic-Todorovic
Keyword(s):
Axon Guidance
◽
Type A
◽
Aminobutyric Acid
◽
Neocortical Neurons
◽
Acid Type
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Faculty Opinions recommendation of Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.718010634.793483802
◽
2013
◽
Author(s):
Edward Bertaccini
Keyword(s):
Gabaa Receptor
◽
Binding Sites
◽
Transmembrane Domain
◽
Type A
◽
Aminobutyric Acid
◽
General Anesthetic
◽
Acid Type
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Faculty Opinions recommendation of Synergistic Modulation of γ-Aminobutyric Acid Type A Receptor-Mediated Synaptic Inhibition in Cortical Networks by Allopregnanolone and Propofol.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
◽
10.3410/f.726644026.793531387
◽
2017
◽
Author(s):
Paul Davies
Keyword(s):
Type A
◽
Aminobutyric Acid
◽
Synaptic Inhibition
◽
Cortical Networks
◽
Acid Type
◽
Synergistic Modulation
Download Full-text
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