Modeling Human Cytochrome P450 2D6 Metabolism and Drug-Drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines

2011 ◽  
Vol 81 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Nico Scheer ◽  
Yury Kapelyukh ◽  
Jillian McEwan ◽  
Vincent Beuger ◽  
Lesley A. Stanley ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Interaction ◽  
Cytochrome P450 2D6 ◽  
Humanized Mouse ◽  
Human Cytochrome ◽  
Drug Drug Interaction ◽  
P450 2D6 ◽  
Mouse Lines

scholarly journals Crystal Structure of Human Cytochrome P450 2D6

2005 ◽  
Vol 281 (11) ◽  
pp. 7614-7622 ◽  
Author(s):  
Paul Rowland ◽  
Frank E. Blaney ◽  
Martin G. Smyth ◽  
Jo J. Jones ◽  
Vaughan R. Leydon ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Cytochrome P450 ◽  
Cytochrome P450 2D6 ◽  
Human Cytochrome ◽  
P450 2D6

Development of a V79 cell line expressing human cytochrome P450 2D6 and its application as a metabolic screening tool

1997 ◽  
Vol 3 (1) ◽  
pp. 31-39 ◽  
Author(s):  
Reimund Rauschenbach ◽  
Hille Gieschen ◽  
Birgit Salomon ◽  
Christian Kraus ◽  
Gerhard Kühne ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cell Line ◽  
Screening Tool ◽  
Cytochrome P450 2D6 ◽  
Human Cytochrome ◽  
Metabolic Screening ◽  
P450 2D6 ◽  
V79 Cell

scholarly journals Inhibition of Human Cytochrome P450 2D6 by Schering 66712

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Brendan Francis Butler ◽  
Jairam Palamanda ◽  
Amin A. Nomeir ◽  
F. Peter Guengerich ◽  
Laura Lowe Furge
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 2D6 ◽  
Human Cytochrome ◽  
P450 2D6

Production of human cytochrome P450 2D6 drug metabolites with recombinant microbes - a comparative study

2012 ◽  
Vol 7 (11) ◽  
pp. 1346-1358 ◽  
Author(s):  
Martina Geier ◽  
Andreas Braun ◽  
Anita Emmerstorfer ◽  
Harald Pichler ◽  
Anton Glieder
Keyword(s):  
Cytochrome P450 ◽  
Comparative Study ◽  
Cytochrome P450 2D6 ◽  
Drug Metabolites ◽  
Human Cytochrome ◽  
P450 2D6
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