scholarly journals Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation

2021 ◽  
Vol 7 (38) ◽  
Author(s):  
Ana Tapia-Abellán ◽  
Diego Angosto-Bazarra ◽  
Cristina Alarcón-Vila ◽  
María C. Baños ◽  
Iva Hafner-Bratkovič ◽  
...  
Keyword(s):  
Inflammasome Activation ◽  
Open Structure ◽  
Intracellular Potassium

scholarly journals OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection

2021 ◽  
Author(s):  
Elinor Hortle ◽  
Lam Vi Tran ◽  
Angela RM Fontaine ◽  
Natalia Pinello ◽  
Justin JL Wong ◽  
...  
Keyword(s):  
Mycobacterial Infection ◽  
Inflammasome Activation ◽  
Zebrafish Embryos ◽  
Protective Effects ◽  
Bacterial Burden ◽  
Potassium Efflux ◽  
Intracellular Potassium ◽  
Nlrp3 Inflammasome Activation ◽  
Tnf Α ◽  
Intracellular Infections

Pathogenic mycobacteria inhibit inflammasome activation as part of their pathogenesis. While it is known that potassium efflux is a trigger for inflammasome activation, the interaction between mycobacterial infection, potassium efflux and inflammasome activation has not been investigated. Here we use Mycobacterium marinum infection of zebrafish embryos to demonstrate that pathogenic mycobacteria upregulate the host WNK signalling pathway kinases SPAK and OXSR1 which control intracellular potassium balance. We show that genetic depletion or inhibition of OXSR1 decreases bacterial burden and intracellular potassium levels. The protective effects of OXSR1 depletion are mediated by NLRP3 inflammasome activation and are dependent on caspase-mediated release of IL-1β and the downstream activation of protective TNF-α. The elucidation of this druggable pathway to potentiate inflammasome activation provides a new avenue for the development of host-directed therapies against intracellular infections.

Construction of Human-size, Open-structure, Vertical Cylindrical Magnetic Shield and Its Evaluation.

2000 ◽  
Vol 24 (4−2) ◽  
pp. 903-906 ◽  
Author(s):  
I. Sasada ◽  
E. Paperno ◽  
H. Koide
Keyword(s):  
Magnetic Shield ◽  
Open Structure

603-P: Circulating Inflammatory Cells and Inflammasome Activation in Diabetics with Diabetic Retinopathy (DR)

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 603-P
Author(s):  
MARIANA D. DUPONT ◽  
ANA LEDA LONGHINI ◽  
GOPALKRISHNA SREEJIT ◽  
RAM PRASAD ◽  
PRABHAKARA NAGAREDDY ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Inflammatory Cells ◽  
Inflammasome Activation

Inflammasomes take the acid test

Inflammasome ◽  
2014 ◽  
Vol 1 (1) ◽  
Author(s):  
David Brough
Keyword(s):  
Extracellular Atp ◽  
Inflammasome Activation ◽  
Danger Signals ◽  
Acid Test

Editorial highlight on Takenouchi et al., ‘Inflammasome activation by danger signals: extracellular ATP and pH.’

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