Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons

Science ◽  
1993 ◽  
Vol 260 (5105) ◽  
pp. 222-226 ◽  
Author(s):  
B. Bacskai ◽  
B Hochner ◽  
M Mahaut-Smith ◽  
Adams ◽  
B. Kaang ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Sensory Neurons ◽  
Spatially Resolved ◽  
Kinase A

Antithrombin reduces endotoxin-induced hypotension by enhancing pulmonary sensory neuron activation in rats

2006 ◽  
Vol 95 (06) ◽  
pp. 1011-1018 ◽  
Author(s):  
Naoaki Harada ◽  
Hirotaka Isobe ◽  
Mitsuhiro Uchiba ◽  
Kenji Okajima
Keyword(s):  
Protein Kinase ◽  
Receptor Antagonist ◽  
Protein Kinase A ◽  
Sensory Neurons ◽  
Therapeutic Effects ◽  
Induced Hypotension ◽  
Cgrp Release ◽  
Neuron Activation ◽  
Tnf Α ◽  
Kinase A

SummaryWe recently demonstrated that activation of the pulmonary sensory neurons plays a critical role in prevention of endotoxininduced shock by releasing calcitonin gene-related peptide (CGRP) in rats. CGRP increased the endothelial production of prostacyclin (PGI2) in the lungs, thereby preventing endotoxininduced shock response by inhibiting tumor necrosis factor-α (TNF-α) production. Since antithrombin (AT) enhances sensory neuron activation, we hypothesized that AT might reduce endotoxin-induced hypotension by enhancing the activation of pulmonary sensory neurons in rats. We examined this possibility using a rat model of endotoxin shock. AT-induced effects including reduction of hypotension (n=5) and inhibition of induction of iNOS (n=4 or 5) and TNF-α (n=5) in the lungs of endotoxin-treated animals were completely reversed by pretreatment with capsazepine (CPZ) (n=4 or 5), a vanilloid receptor antagonist, or CGRP(8–37), a CGRP receptor antagonist (n=4 or 5). AT enhanced endotoxin-induced increases in lung tissue levels of CGRP (n=4), but this effect of AT was not seen in animals pretreated with CPZ (n=4). CGRP produced therapeutic effects (n=5) similar to those induced by AT, and such therapeutic effects were completely abrogated by pretreatment with indomethacin (n=4). AT increased CGRP release from cultured dorsal root ganglion neurons only in the presence of anandamide (n=5),andAT-induced increase in CGRP release was not observed in the presence KT5720, an inhibitor of protein kinase A (n=5). AT markedly increased intracellular levels of cAMP in the presence of anandamide (n=5).These results strongly suggested that AT might reduce endotoxin-induced hypotension in rats by enhancing activation of sensory neurons via activation of protein kinase A.

Protein kinase A regulates inflammatory pain sensitization by modulating HCN2 channel activity in nociceptive sensory neurons

Pain ◽  
2017 ◽  
Vol 158 (10) ◽  
pp. 2012-2024 ◽  
Author(s):  
Stefan Herrmann ◽  
Hamsa Rajab ◽  
Irina Christ ◽  
Christoph Schirdewahn ◽  
Daniel Höfler ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Sensory Neurons ◽  
Inflammatory Pain ◽  
Channel Activity ◽  
Pain Sensitization ◽  
Kinase A

scholarly journals Nerve Growth Factor Mediates a Switch in Intracellular Signaling for PGE2-Induced Sensitization of Sensory Neurons from Protein Kinase A to Epac

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e104529 ◽  
Author(s):  
Michael R. Vasko ◽  
Ramy Habashy Malty ◽  
Chunlu Guo ◽  
Djane B. Duarte ◽  
Yihong Zhang ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Sensory Neurons ◽  
Intracellular Signaling ◽  
Nerve Growth ◽  
Kinase A

scholarly journals Modulation of a cAMP/Protein Kinase A Cascade by Protein Kinase C in Sensory Neurons ofAplysia

1997 ◽  
Vol 17 (19) ◽  
pp. 7237-7244 ◽  
Author(s):  
Shuzo Sugita ◽  
Douglas A. Baxter ◽  
John H. Byrne
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Sensory Neurons ◽  
Kinase C ◽  
Kinase A

scholarly journals Protein Kinase A Anchoring via AKAP150 Is Essential for TRPV1 Modulation by Forskolin and Prostaglandin E2 in Mouse Sensory Neurons

2008 ◽  
Vol 28 (19) ◽  
pp. 4904-4917 ◽  
Author(s):  
K. Schnizler ◽  
L. P. Shutov ◽  
M. J. Van Kanegan ◽  
M. A. Merrill ◽  
B. Nichols ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Prostaglandin E2 ◽  
Protein Kinase A ◽  
Sensory Neurons ◽  
Kinase A
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