scholarly journals Use of the Surgical Wound Infection Model To Determine the Efficacious Dosing Regimen of Retapamulin, a Novel Topical Antibiotic

2006 ◽  
Vol 50 (11) ◽  
pp. 3886-3888 ◽  
Author(s):  
Stephen Rittenhouse ◽  
Christine Singley ◽  
Jennifer Hoover ◽  
Roni Page ◽  
David Payne
Keyword(s):  
Staphylococcus Aureus ◽  
Clinical Trials ◽  
Wound Infection ◽  
Streptococcus Pyogenes ◽  
Surgical Wound Infection ◽  
Infection Model ◽  
Surgical Wound ◽  
Dosing Regimen ◽  
Topical Antibiotic ◽  
Dosing Regimens

ABSTRACT The effect of topically applied retapamulin ointment was evaluated using various dosing regimens in the Staphylococcus aureus and Streptococcus pyogenes wound infection model. Retapamulin (1%, wt/wt) was efficacious using twice-daily (b.i.d.) applications for 4 or 5 days. These data underpinned the decision to evaluate 1% retapamulin b.i.d. in clinical trials.

scholarly journals Vaccination with Detoxified Leukocidin AB Reduces Bacterial Load in a Staphylococcus aureus Minipig Deep Surgical Wound Infection Model

2021 ◽  
Author(s):  
J Fernandez ◽  
H Sanders ◽  
J Henn ◽  
J M Wilson ◽  
D Malone ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Wound Infection ◽  
Bacterial Load ◽  
Surgical Wound Infection ◽  
Vaccine Antigen ◽  
Infection Model ◽  
Surgical Wound ◽  
Log Reduction ◽  
Efficacy Trials ◽  
Attractive Option

Abstract Vaccines against Staphylococcus aureus have eluded researchers for over three decades while the burden of staphylococcal diseases has increased. Early vaccine attempts mainly used rodents to characterize preclinical efficacy, and all subsequently failed in human clinical efficacy trials. More recently, the leukocidin LukAB has gained interest as a vaccine antigen. We developed a minipig deep surgical wound infection model offering three independent efficacy readouts: bacterial load at the superficial and at the deep-seated surgical site, and dissemination of bacteria. Due to similarities with humans, minipigs are an attractive option to study novel vaccine candidates. With this model, we characterized the efficacy of a LukAB toxoid as vaccine candidate. Compared to control animals, a 3-log reduction of bacteria at the deep-seated surgical site was observed in LukAB-treated minipigs and dissemination of bacteria was dramatically reduced. Therefore, LukAB toxoids may be a useful addition to S. aureus vaccines and warrant further study.

scholarly journals Therapeutic Efficacy of Halocidin-Derived Peptide HG1 in a Mouse Model of Surgical Wound Infection with Methicillin-ResistantStaphylococcus aureus

2011 ◽  
Vol 55 (3) ◽  
pp. 1296-1299 ◽  
Author(s):  
Young Shin Lee ◽  
Yong Pyo Shin ◽  
Seo Hwa Shin ◽  
Seungmi Park ◽  
Myung Hwa Kim ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Mouse Model ◽  
Skin Infection ◽  
Therapeutic Potential ◽  
Surgical Wound Infection ◽  
Infection Site ◽  
Surgical Wound ◽  
Topical Antibiotic ◽  
Wound Model ◽  
Bacterial Enumeration

ABSTRACTWe evaluated the therapeutic potential of HG1, an antimicrobial peptide, as a novel topical antibiotic by the use of a mouse surgical wound model of infection with methicillin-resistantStaphylococcus aureus. First, we attempted to determine whether or not HG1 infiltrated into the dermis when topically administered. Second, we evaluated the antibiotic effects of HG1 on skin infection via bacterial-enumeration and microscopic analyses. The results showed that topically administered HG1 was capable of penetrating into the dermis at the infection site, where it exerted its antimicrobial effects.

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