An outbreak of Staphylococcus aureus surgical wound infection associated with excess overtime employment of operating room personnel

1983 ◽  
Vol 11 (2) ◽  
pp. 63-67 ◽  
Author(s):  
Barbara Russell ◽  
N.Joel Ehrenkranz ◽  
Phineas J. Hyams ◽  
Carin A. Gribbie
2011 ◽  
Vol 52 (3) ◽  
Author(s):  
Moraima Guevara Rodrìguez ◽  
Juan Josè Romero Zúñiga

Aim: Hospital surgical wound infection (SWI) is one of the three most frequent causes of nosocomial infection worldwide, leading to high social and medical costs. This study aims to identify and quantify risk factors for SWI in a Costa Rican hospital. Methods: A cohort study of 488 elective patients operated between April and June 2006. The patients were divided in 2 groups: those in which operating room traffic was restricted, group A, and those in which it was not, group B. The statistical analysis was performed in 2 major phases: descriptive and analytical. In the first one, frequency measures (absolute and relative) were calculated; and the second one was carried out in 2 stages; both of them through unconditional logistic regression, univariate and multivariate analysis. Results: An overall incidence of 35.2 % (172/488) of SWI was found. The cumulative incidence in the unexposed was 31.8% (76/239), while in those exposed, it was 38.6% (96/249) (p=0.12). Only organ and bone/joint surgery presented a higher risk of SWI (OR 2.42; 95% CI:1.5-3.8), surgeries in unrestricted traffic rooms and diabetes had no association with the infection. Conclusion: Diabetes and depth of surgery should be taken into account in the profile of patients with increased risk of suffering SWI; furthermore, even though there was no epidemiological association between restricted operating room traffic and not restricted, and SWI, although the difference in incidence of SWI, was not statistically significant, it is advisable to restrict the transit of persons in operating rooms, according to international standards.


Author(s):  
J Fernandez ◽  
H Sanders ◽  
J Henn ◽  
J M Wilson ◽  
D Malone ◽  
...  

Abstract Vaccines against Staphylococcus aureus have eluded researchers for over three decades while the burden of staphylococcal diseases has increased. Early vaccine attempts mainly used rodents to characterize preclinical efficacy, and all subsequently failed in human clinical efficacy trials. More recently, the leukocidin LukAB has gained interest as a vaccine antigen. We developed a minipig deep surgical wound infection model offering three independent efficacy readouts: bacterial load at the superficial and at the deep-seated surgical site, and dissemination of bacteria. Due to similarities with humans, minipigs are an attractive option to study novel vaccine candidates. With this model, we characterized the efficacy of a LukAB toxoid as vaccine candidate. Compared to control animals, a 3-log reduction of bacteria at the deep-seated surgical site was observed in LukAB-treated minipigs and dissemination of bacteria was dramatically reduced. Therefore, LukAB toxoids may be a useful addition to S. aureus vaccines and warrant further study.


2006 ◽  
Vol 50 (11) ◽  
pp. 3886-3888 ◽  
Author(s):  
Stephen Rittenhouse ◽  
Christine Singley ◽  
Jennifer Hoover ◽  
Roni Page ◽  
David Payne

ABSTRACT The effect of topically applied retapamulin ointment was evaluated using various dosing regimens in the Staphylococcus aureus and Streptococcus pyogenes wound infection model. Retapamulin (1%, wt/wt) was efficacious using twice-daily (b.i.d.) applications for 4 or 5 days. These data underpinned the decision to evaluate 1% retapamulin b.i.d. in clinical trials.


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