In Vitro Activity of Sulopenem, an Oral Penem, against Urinary Isolates of Escherichia coli
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ABSTRACT The in vitro activity of sulopenem was assessed against a collection from 2014 to 2016 of 539 urinary isolates of Escherichia coli from Canadian patients by using CLSI-defined broth microdilution methodology. A concentration of sulopenem 0.03 µg/ml inhibited both 50% (MIC50) and 90% (MIC90) of isolates tested; sulopenem MICs ranged from 0.015 to 0.25 µg/ml. The in vitro activity of sulopenem was unaffected by nonsusceptibility to trimethoprim-sulfamethoxazole and/or ciprofloxacin, multidrug-resistant phenotypes, extended-spectrum β-lactamases, or AmpC β-lactamases.
2009 ◽
Vol 53
(11)
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pp. 4924-4926
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2011 ◽
Vol 55
(6)
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pp. 2992-2994
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2015 ◽
Vol 45
(5)
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pp. 485-490
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2006 ◽
Vol 54
(2)
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pp. 135-139
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2020 ◽
Vol 96
(4)
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pp. 114925
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1985 ◽
Vol 27
(4)
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pp. 449-451
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