scholarly journals Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities.

1996 ◽  
Vol 40 (1) ◽  
pp. 234-236 ◽  
Author(s):  
S Rusconi ◽  
M Moonis ◽  
D P Merrill ◽  
P V Pallai ◽  
E A Neidhardt ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Mononuclear Cells ◽  
T Cell Proliferation ◽  
Peripheral Blood Mononuclear ◽  
Primary Monocyte ◽  
Immunodeficiency Virus ◽  
Blood Mononuclear Cells

PIC 024-4 and PRO 2000 are naphthalene sulfonate polymers that bind to CD4 with nanomolar affinity and block binding of gp120. Both have activity against human immunodeficiency virus type 1 in H9 cells, peripheral blood mononuclear cells, and primary monocyte/macrophages, are synergistic with zidovudine, and do not inhibit tetanus toxoid-stimulated T-cell proliferation at anti-human immunodeficiency virus type 1 concentrations.

Synergistic Inhibition of Primary Isolates of Human Immunodeficiency Virus Type 1 by Combinations of 3′-Fluoro-3′-Deoxythymidine and 2′,3′-Dideoxyinosine

1993 ◽  
Vol 4 (4) ◽  
pp. 241-244 ◽  
Author(s):  
S. W. Cox ◽  
J. Albert ◽  
K. Aperia ◽  
B. Wahren
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Mononuclear Cells ◽  
Antiviral Effect ◽  
Clinical Situation ◽  
Peripheral Blood Mononuclear ◽  
Immunodeficiency Virus ◽  
The Individual

We examined the antiviral effect against human immunodeficiency virus type 1 of 3′-fluoro-3′-deoxythymidine and 2′,3′-dideoxyinosine, both alone and in combination. Primary isolates of human immunodeficiency virus were used directly after isolation on peripheral blood mononuclear cells, without culturing on established cell lines, in order to maintain close similarity to the clinical situation. All isolates were synergistically inhibited by combinations of the drugs, though their susceptibility to the separate drugs varied. The selectivity indices of the combinations were similar to that of the individual drugs. The synergistic combination of 3′-fluoro-3′-deoxythymidine and 2′,3′-dideoxyinosine appears promising for the treatment of human immunodeficiency virus infection and deserves further investigation.

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