Antitrypanosomal Activity of Fluoroquinolones
1999 ◽
Vol 43
(8)
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pp. 2066-2068
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Keyword(s):
Type Ii
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ABSTRACT Six fluoroquinolones presently in clinical use and four investigational tetracyclic fluoroquinolones were tested for in vitro activity against bloodstream-form Trypanosoma brucei brucei. All compounds had measurable activity, but the tetracyclic analogs were most potent, with 50% effective concentrations in the low micromolar range. In general, trypanosomes were more susceptible than L1210 leukemia cells. Consistent with the notion that they target type II topoisomerase in trypanosomes, the fluoroquinolones promote the formation of protein-DNA covalent complexes.
1996 ◽
Vol 10
(7)
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pp. 559-562
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2010 ◽
Vol 54
(7)
◽
pp. 2893-2900
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1996 ◽
Vol 81
(2)
◽
pp. 127-136
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Keyword(s):
2019 ◽
Vol 45
(4)
◽
pp. 683-688
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2003 ◽
Vol 2
(11)
◽
pp. 474-476
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