Deletion of the Multiple-Drug Efflux Pump AcrAB in Escherichiacoli Prolongs the Postantibiotic Effect
2005 ◽
Vol 49
(3)
◽
pp. 1206-1208
◽
Keyword(s):
ABSTRACT The mechanism of the postantibiotic effect (PAE) was examined in Escherichia coli. Drugs exhibited longer-lasting PAEs in an acrAB mutant, suggesting that intracellular drug concentrations influence the duration of the PAE. With specific assays for tetracycline and erythromycin, a direct link between intracellular persistence of antibiotics and maintenance of the PAE was established.
Keyword(s):
Keyword(s):
Keyword(s):
1999 ◽
Vol 277
(1)
◽
pp. F84-F96
◽
Keyword(s):
2005 ◽
Vol 349
(2)
◽
pp. 387-400
◽
2002 ◽
Vol 49
(4)
◽
pp. 619-624
◽