scholarly journals Biotin-Binding Proteins in the Defense of Mushrooms against Predators and Parasites

2012 ◽  
Vol 78 (23) ◽  
pp. 8485-8487 ◽  
Author(s):  
Silvia Bleuler-Martinez ◽  
Stefanie Schmieder ◽  
Markus Aebi ◽  
Markus Künzler
Keyword(s):  
Antifungal Activity ◽  
Chemical Defense ◽  
Binding Proteins ◽  
High Toxicity ◽  
Defense System ◽  
Biotin Binding

ABSTRACTTamavidins are fungal biotin-binding proteins (BBPs) displaying antifungal activity against phytopathogens. Here we show high toxicity of tamavidins toward nematodes, insects, and amoebae. As these organisms represent important phyla of fungal predators and parasites, we propose that BBPs are part of the chemical defense system of fungi.

scholarly journals One Century of Study: What We Learned about Paracoccidioides and How This Pathogen Contributed to Advances in Antifungal Therapy

2021 ◽  
Vol 7 (2) ◽  
pp. 106
Author(s):  
Erika Seki Kioshima ◽  
Patrícia de Souza Bonfim de Mendonça ◽  
Marcus de Melo Teixeira ◽  
Isis Regina Grenier Capoci ◽  
André Amaral ◽  
...  
Keyword(s):  
Latin America ◽  
Life Cycle ◽  
Antifungal Activity ◽  
Molecular Biology ◽  
Antifungal Therapy ◽  
High Toxicity ◽  
Development Stages ◽  
Thioredoxin System ◽  
Nanostructured Systems ◽  
Advanced Development

Paracoccidioidomycosis (PCM) is a notable fungal infection restricted to Latin America. Since the first description of the disease by Lutz up to the present day, Brazilian researchers have contributed to the understanding of the life cycle of this pathogen and provided the possibility of new targets for antifungal therapy based on the structural and functional genomics of Paracoccidioides. In this context, in silico approaches have selected molecules that act on specific targets, such as the thioredoxin system, with promising antifungal activity against Paracoccidioides. Some of these are already in advanced development stages. In addition, the application of nanostructured systems has addressed issues related to the high toxicity of conventional PCM therapy. Thus, the contribution of molecular biology and biotechnology to the advances achieved is unquestionable. However, it is still necessary to transcend the boundaries of synthetic chemistry, pharmaco-technics, and pharmacodynamics, aiming to turn promising molecules into newly available drugs for the treatment of fungal diseases.

Expression of various biotin-binding proteins in transgenic tobacco confers resistance to potato tuber moth, Phthorimaea operculella (Zeller) (fam. Gelechiidae)

2010 ◽  
Vol 19 (6) ◽  
pp. 1041-1051 ◽  
Author(s):  
Colleen Murray ◽  
Ngaire P. Markwick ◽  
Ryohei Kaji ◽  
Joanne Poulton ◽  
Harry Martin ◽  
...  
Keyword(s):  
Potato Tuber ◽  
Transgenic Tobacco ◽  
Binding Proteins ◽  
Phthorimaea Operculella ◽  
Potato Tuber Moth ◽  
Biotin Binding

One-step fabrication of LSPR-tuneable reconfigurable assemblies of gold nanoparticles decorated with biotin-binding proteins

Nanoscale ◽  
2017 ◽  
Vol 9 (47) ◽  
pp. 18855-18860 ◽  
Author(s):  
R. de la Rica
Keyword(s):  
Gold Nanoparticles ◽  
Binding Proteins ◽  
Chemical Cues ◽  
Biotin Binding ◽  
One Step

Biotin-binding proteins trigger the assembly of chain-like clusters of gold nanoparticles that reconfigure as a function of chemical cues in their environment.

Biotin-binding proteins

1994 ◽  
pp. 200-249 ◽  
Author(s):  
Krishnamurti Dakshinamurti ◽  
Jasbir Chauhan
Keyword(s):  
Binding Proteins ◽  
Biotin Binding

scholarly journals Relationship between biotin-binding proteins from chicken plasma and egg yolk

1978 ◽  
Vol 175 (2) ◽  
pp. 629-633 ◽  
Author(s):  
R D Mandella ◽  
H W Meslar ◽  
H B White
Keyword(s):  
Binding Proteins ◽  
Elevated Temperatures ◽  
Binding Protein ◽  
Gel Filtration ◽  
Egg Yolk ◽  
Egg White ◽  
Similar Molecular Weight ◽  
Precipitin Line ◽  
Ion Exchange Column ◽  
Biotin Binding

The plasma of laying hens contains a specific biotin-binding protein that appears to be identical with an egg-yolk biotin-binding protein. Both proteins are saturated with biotin and require elevated temperatures to effect the exchange of [14C]biotin for the protein-bound vitamin. The heat-exchange curve in each case is the same and differs sharply from that of avidin, the egg-white biotin-binding protein. On Sephadex G-100 gel filtration, plasma and yolk biotin-binding proteins were each eluted slightly ahead of avidin (mol.wt. 68,000), suggesting that they are of similar molecular weight. Plasma and yolk biotin-binding proteins required the same ionic strength to be eluted from a phosphocellulose ion-exchange column. Both the plasma and yolk biotin-binding proteins had a pI of 5; avidin has a pI of 10. Plasma biotin-binding protein cross-reacted with antiserum to yolk biotin-binding protein and showed a precipitin line of identity with purified yolk biotin-binding protein. It is suggested that biotin-binding plays an important role in mediating the transport of the vitamin from the bloodstream to the developing oocyte.

The Use of Biotin-Binding Proteins for Insect Control

2010 ◽  
Vol 103 (2) ◽  
pp. 497-508 ◽  
Author(s):  
John T. Christeller ◽  
Ngaire P. Markwick ◽  
Elisabeth P. J. Burgess ◽  
Louise A. Malone
Keyword(s):  
Binding Proteins ◽  
Insect Control ◽  
Biotin Binding
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