Transition Metal Homeostasis

EcoSal Plus ◽  
2009 ◽  
Vol 3 (2) ◽  
Author(s):  
Dietrich H. Nies ◽  
Gregor Grass
Keyword(s):  
Transition Metal ◽  
Metal Homeostasis

Manganese privation induced transcriptional upregulation of the class IIa bacteriocin plantaricin 423 in Lactobacillus plantarum 423

2021 ◽  
Author(s):  
Ross Vermeulen ◽  
Shelly Deane ◽  
Leon Dicks ◽  
Johann Rohwer ◽  
Anton Du Preez van Staden
Keyword(s):  
Transition Metal ◽  
Lactobacillus Plantarum ◽  
Foodborne Pathogens ◽  
Economic Value ◽  
Metal Homeostasis ◽  
Culture Conditions ◽  
Reporter System ◽  
Precursor Peptide ◽  
Enterocin A ◽  
Leucocin A

Plantaricin 423 is produced by Lactobacillus plantarum 423 using the pla biosynthetic operon located on the 8188 bp plasmid, pPLA4. As with many class IIa bacteriocin operons, the pla operon encodes biosynthetic genes ( plaA : precursor peptide, plaB : immunity, plaC : accessory and plaD : ABC transporter) but does not encode local regulatory genes. Little is known about the regulatory mechanisms involved in the expression of the apparently regulationless class IIa bacteriocins such as plantaricin 423. In this study, phylogenetic analysis of class IIa immunity proteins indicated that at least three distinct clades exist, which were then used to subgroup the class IIa operons. It became evident that the absence of classical quorum sensing genes on mobile bacteriocin encoding elements is a predisposition of the subgroup which includes plantaricin 423, pediocin AcH/PA-1, divercin V41, enterocin A, leucocin-A and -B, mesentericin Y105 and sakacin G. Further analysis of the subgroup suggested that the regulation of these class IIa operons may be linked to transition metal homeostasis in the host. By using a fluorescent promoter-reporter system in Lactobacillus plantarum 423, transcriptional regulation of plantaricin 423 was shown to be upregulated in response to manganese privation. IMPORTANCE Lactic acid bacteria hold huge industrial application and economic value, especially bacteriocinogenic strains which further aids in the exclusion of specific foodborne pathogens. Since bacteriocinogenic strains are sought after it is equally important to understand the mechanism of bacteriocin regulation. This is currently an understudied aspect of class IIa operons. Our research suggests the existence of a previously undescribed mode of class IIa bacteriocin regulation, whereby bacteriocin expression is linked to management of the producer’s transition metal homeostasis. This delocalized metalloregulatory model may fundamentally affect the selection of culture conditions for bacteriocin expression and change our understanding of class IIa bacteriocin gene transfer dynamics in a given microbiome.

Transition Metal Homeostasis in Streptococcus pyogenes and Streptococcus pneumoniae

2017 ◽  
pp. 123-191 ◽  
Author(s):  
Andrew G. Turner ◽  
Cheryl-lynn Y. Ong ◽  
Mark J. Walker ◽  
Karrera Y. Djoko ◽  
Alastair G. McEwan
Keyword(s):  
Streptococcus Pneumoniae ◽  
Transition Metal ◽  
Streptococcus Pyogenes ◽  
Metal Homeostasis

scholarly journals Developing drugs targeting transition metal homeostasis

2017 ◽  
Vol 37 ◽  
pp. 26-32 ◽  
Author(s):  
Claire M. Weekley ◽  
Chuan He
Keyword(s):  
Transition Metal ◽  
Metal Homeostasis

Essential transition metal homeostasis in plants

2009 ◽  
Vol 12 (3) ◽  
pp. 347-357 ◽  
Author(s):  
Marinus Pilon ◽  
Christopher M Cohu ◽  
Karl Ravet ◽  
Salah E Abdel-Ghany ◽  
Frederic Gaymard
Keyword(s):  
Transition Metal ◽  
Metal Homeostasis

scholarly journals Medicago truncatula Yellow Stripe-Like7 encodes a peptide transporter required for symbiotic nitrogen fixation

2020 ◽  
Author(s):  
Rosario Castro-Rodríguez ◽  
María Reguera ◽  
Viviana Escudero ◽  
Patricia Gil-Díez ◽  
Julia Quintana ◽  
...  
Keyword(s):  
Nitrogen Fixation ◽  
Transition Metal ◽  
Medicago Truncatula ◽  
Symbiotic Nitrogen Fixation ◽  
Root Nodules ◽  
Metal Homeostasis ◽  
Peptide Transporter ◽  
Short Peptides ◽  
Yellow Stripe ◽  
Mutant Lines

ABSTRACTYellow Stripe-Like (YSL) proteins are a family of plant transporters typically involved in transition metal homeostasis. The substrate of three of the four YSL clades (clades I, II, and IV) are metal complexes with non-proteinogenic amino acid nicotianamine or its derivatives. No such transport capabilities have been shown for any member of the remaining clade (clade III), which is able to translocate short peptides across the membranes instead. The connection between clade III YSL members and metal homeostasis might have been masked by the functional redundancy characteristic of this family. This might have been circumvented in legumes through neofunctionalization of YSLs to ensure a steady supply of transition metals for symbiotic nitrogen fixation in root nodules. To test this possibility, Medicago truncatula clade III transporter MtYSL7 has been studied both when the plant was fertilized with ammonium nitrate or when nitrogen had to be provided by endosymbiotic rhizobia within the root nodules. MtYSL7 is a plasma membrane protein expressed in the vasculature and in the nodule cortex. This protein is able to transport short peptides into the cytosol, although none with known metal homeostasis roles. Reducing MtYSL7 expression levels resulted in diminished nitrogen fixation rates. In addition, nodules of mutant lines lacking YSL7 accumulated more copper and iron, the later the likely result of increased expression in roots of iron uptake and delivery genes. The available data is indicative of a role of MtYSL7, and likely other clade III YSLs, in transition metal homeostasis.ONE SENTENCE SUMMARYMedicago truncatula YSL7 is a peptide transporter required for symbiotic nitrogen fixation in legume nodules, likely controlling transition metal allocation to these organs.

Transition Metal Homeostasis and Its Role in Plant Growth and Development

2021 ◽  
pp. 159-178
Author(s):  
Yamshi Arif ◽  
Priyanka Singh ◽  
Husna Siddiqui ◽  
Romana Naaz ◽  
Shamsul Hayat
Keyword(s):  
Transition Metal ◽  
Plant Growth ◽  
Growth And Development ◽  
Metal Homeostasis ◽  
Plant Growth And Development

scholarly journals Biophysical and Bioinformatic Analyses Implicate the Treponema pallidum Tp34 Lipoprotein (Tp0971) in Transition Metal Homeostasis

2012 ◽  
Vol 194 (24) ◽  
pp. 6771-6781 ◽  
Author(s):  
C. A. Brautigam ◽  
R. K. Deka ◽  
Z. Ouyang ◽  
M. Machius ◽  
G. Knutsen ◽  
...  
Keyword(s):  
Transition Metal ◽  
Treponema Pallidum ◽  
Metal Homeostasis
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