scholarly journals Inhibition of Streptococcus mutans adherence to saliva-coated hydroxyapatite by human secretory immunoglobulin A (S-IgA) antibodies to cell surface protein antigen I/II: reversal by IgA1 protease cleavage.

1992 ◽  
Vol 60 (12) ◽  
pp. 5057-5064 ◽  
Author(s):  
G Hajishengallis ◽  
E Nikolova ◽  
M W Russell
Keyword(s):  
Cell Surface ◽  
Streptococcus Mutans ◽  
Immunoglobulin A ◽  
Surface Protein ◽  
Secretory Immunoglobulin A ◽  
Cell Surface Protein ◽  
Protease Cleavage ◽  
Iga1 Protease ◽  
Iga Antibodies ◽  
Secretory Immunoglobulin

scholarly journals Fecal Immunoglobulin A Antibodies in Dogs Infected or Vaccinated with Canine Coronavirus

2004 ◽  
Vol 11 (1) ◽  
pp. 102-105 ◽  
Author(s):  
Nicola Decaro ◽  
Annamaria Pratelli ◽  
Antonella Tinelli ◽  
Vito Martella ◽  
Michele Camero ◽  
...  
Keyword(s):  
Immunosorbent Assay ◽  
Immunoglobulin A ◽  
Enzyme Linked Immunosorbent Assay ◽  
Inactivated Vaccine ◽  
Secretory Immunoglobulin A ◽  
Intramuscular Route ◽  
Degree Of Protection ◽  
Canine Coronavirus ◽  
Iga Antibodies ◽  
Secretory Immunoglobulin

ABSTRACT Fecal secretory immunoglobulin A (IgA) antibodies in dogs infected or vaccinated with canine coronavirus (CCV) were evaluated by an enzyme-linked immunosorbent assay. The study was carried out with 32 fecal samples collected just before inoculation and at 28 days postinoculation. Five groups were studied: naturally infected dogs, experimentally infected dogs, dogs inoculated with a modified live (ML) CCV vaccine by the intramuscular route, dogs inoculated with an ML CCV vaccine by the oronasal route, and dogs given an inactivated CCV vaccine. Both the naturally and the experimentally infected dogs developed high levels of fecal IgAs. Interestingly, dogs inoculated with the ML CCV vaccine by the oronasal route developed levels of fecal IgA that were higher than those observed in the dogs inoculated with the same CCV vaccine by the intramuscular route or those observed in dogs inoculated with the inactivated vaccine. A relationship between the level of fecal IgAs to CCV and the degree of protection against CCV infection was observed.

scholarly journals Characterization of a Cell-surface Protein Antigen of Hydrophilic Streptococcus mutans Strain GS-5

Microbiology ◽  
1989 ◽  
Vol 135 (4) ◽  
pp. 981-988 ◽  
Author(s):  
H. Ohta ◽  
H. Kato ◽  
N. Okahashi ◽  
I. Takahashi ◽  
S. Hamada ◽  
...  
Keyword(s):  
Cell Surface ◽  
Streptococcus Mutans ◽  
Surface Protein ◽  
Protein Antigen ◽  
Cell Surface Protein ◽  
A Cell

Contribution of cell surface protein antigen PAc of Streptococcus mutans to bacteremia

2006 ◽  
Vol 8 (1) ◽  
pp. 114-121 ◽  
Author(s):  
Kazuhiko Nakano ◽  
Masato Tsuji ◽  
Kaoru Nishimura ◽  
Ryota Nomura ◽  
Takashi Ooshima
Keyword(s):  
Cell Surface ◽  
Streptococcus Mutans ◽  
Surface Protein ◽  
Protein Antigen ◽  
Cell Surface Protein

Protein Antigen in Serotype k Streptococcus mutans Clinical Isolates

2008 ◽  
Vol 87 (10) ◽  
pp. 964-968 ◽  
Author(s):  
K. Nakano ◽  
R. Nomura ◽  
H. Nemoto ◽  
J. Lapirattanakul ◽  
N. Taniguchi ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Dental Caries ◽  
Cell Surface ◽  
Streptococcus Mutans ◽  
Western Blotting ◽  
Surface Protein ◽  
Clinical Isolates ◽  
Cell Surface Protein ◽  
Western Blotting Analysis ◽  
Blotting Analysis

Streptococcus mutans, a major pathogen of dental caries and infective endocarditis, is classified into serotypes c, e, f, and k, with serotype k strains recently reported to be frequently detected in persons with infective endocarditis. Thus, we hypothesized that common properties associated with infective endocarditis are present in those strains. Fifty-six oral S. mutans strains, including 11 serotype k strains, were analyzed. Western blotting analysis revealed expression of the 3 types of glucosyltransferases in all strains, while expression of the approximately 190-kDa cell-surface protein (PA) was absent in 12 strains, among which the prevalence of serotype k (7/12) was significantly high. Furthermore, cellular hydrophobicity and phagocytosis susceptibility were lower in the group of serotype k strains. These results indicate that the absence of PA expression, low cellular hydrophobicity, and phagocytosis susceptibility are common bacterial properties associated with serotype k strains, which may be associated with virulence for infective endocarditis.

A DNA Vaccine Encoding a Cell-surface Protein Antigen of Streptococcus mutans Protects Gnotobiotic Rats from Caries

2002 ◽  
Vol 81 (11) ◽  
pp. 784-787 ◽  
Author(s):  
M.W. Fan ◽  
Z. Bian ◽  
Z.X. Peng ◽  
Y. Zhong ◽  
Z. Chen ◽  
...  
Keyword(s):  
Dental Caries ◽  
Cell Surface ◽  
Streptococcus Mutans ◽  
Dna Vaccine ◽  
Recombinant Dna ◽  
Surface Protein ◽  
Protein Antigen ◽  
Cell Surface Protein ◽  
Igg Antibody ◽  
A Cell

A cell-surface protein antigen (PAc) of Streptococcus mutans is considered a virulence factor because it may mediate initial attachment of Streptococcus mutans to tooth surfaces. Thus, inhibiting PAc is predicted to provide protection against caries. To develop vaccines against dental caries, we constructed a DNA vaccine, pCIA-P, which encodes two high-conservative regions of PAc. Expression of the recombinant protein was obtained in eukaryotic cells in vitro and in vivo. In this report, we provide evidence that fewer caries lesions, and high levels of PAc-specific salivary IgA antibody and serum IgG antibody, were observed in gnotobiotic rats following targeted salivary gland (TSG) administration of pCIA-P. This study shows that the recombinant DNA vaccine pCIA-P could induce protective anti-caries immune responses and that TSG immunization is a promising strategy for the inhibition of dental caries.

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