CD4+ T Lymphocytes from Anaplasma marginale Major Surface Protein 2 (MSP2) Vaccinees Recognize Naturally Processed Epitopes Conserved in MSP3
2004 ◽
Vol 72
(6)
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pp. 3688-3692
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Keyword(s):
ABSTRACT Major surface protein 2 (MSP2) and MSP3 of the persistent bovine ehrlichial pathogen Anaplasma marginale are immunodominant proteins that undergo antigenic variation. The recently completed sequence of MSP3 revealed blocks of amino acids in the N and C termini that are conserved with MSP2. This study tested the hypothesis that CD4+ T cells specific for MSP2 recognize naturally processed epitopes conserved in MSP3. At least one epitope in the N terminus and two in the C terminus of MSP2 were also processed from MSP3 and presented to CD4+ T lymphocytes from MSP2-immunized cattle. This T-lymphocyte response to conserved and partially conserved epitopes may contribute to the immunodominance of MSP2 and MSP3.
Keyword(s):
2001 ◽
Vol 69
(8)
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pp. 5151-5156
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2001 ◽
Vol 69
(5)
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pp. 3057-3066
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2006 ◽
Vol 101
(5)
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pp. 511-516
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Keyword(s):
Phylogeography of New World isolates of Anaplasma marginale based on major surface protein sequences
2002 ◽
Vol 88
(3)
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pp. 275-285
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Keyword(s):