Neutralization of Tumor Necrosis Factor Alpha Suppresses Antigen-Specific Type 1 Cytokine Responses and Reverses the Inhibition of Mycobacterial Survival in Cocultures of Immune Guinea Pig T Lymphocytes and Infected Macrophages
2005 ◽
Vol 73
(12)
◽
pp. 8437-8441
◽
Keyword(s):
Tnf Α
◽
ABSTRACT Neutralization of tumor necrosis factor alpha (TNF-α) significantly down-regulated antigen-induced lymphoproliferation and the expression of interleukin-12 p40 and gamma interferon mRNA and enhanced the viability of intracellular attenuated and virulent mycobacteria in cocultures of immune T cells and macrophages obtained from Mycobacterium bovis BCG-vaccinated guinea pigs. This suggests the crucial role of TNF-α in the activation of a type 1 T-cell response against Mycobacterium tuberculosis infection.
2001 ◽
Vol 69
(11)
◽
pp. 6651-6659
◽
2006 ◽
Vol 26
(24)
◽
pp. 9244-9255
◽
2001 ◽
Vol 69
(11)
◽
pp. 7169-7172
◽
2001 ◽
Vol 69
(8)
◽
pp. 4823-4830
◽