scholarly journals Bacterial and Host Factors Implicated in Nasal Carriage of Methicillin-Resistant Staphylococcus aureus in Mice

2005 ◽  
Vol 73 (3) ◽  
pp. 1847-1851 ◽  
Author(s):  
Bruno González-Zorn ◽  
Jose P. M. Senna ◽  
Laurence Fiette ◽  
Spencer Shorte ◽  
Aurélie Testard ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Nasal Carriage ◽  
Transmembrane Conductance Regulator ◽  
Toll Like Receptor ◽  
Transmembrane Conductance ◽  
Methicillin Resistant ◽  
Toll Like Receptor 2 ◽  
Resistant Strains ◽  
Cystic Fibrosis Transmembrane ◽  
Deficient Mice

ABSTRACT Nasal carriage is a major risk factor for Staphylococcus aureus infection, especially for methicillin-resistant strains (MRSA). Using a mouse model of nasal carriage, we have compared several S. aureus strains and demonstrated increased colonization levels by MRSA in cystic fibrosis transmembrane conductance regulator-deficient mice and Toll-like receptor 2 (TLR2)-deficient mice but not TLR4-deficient mice.

Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor

1996 ◽  
Vol 12 (3) ◽  
pp. 280-287 ◽  
Author(s):  
Richard Rozmahe ◽  
Michael Wilschanski ◽  
Angabin Matin ◽  
Suzanne Plyte ◽  
Mary Oliver ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Disease Severity ◽  
Genetic Factor ◽  
Transmembrane Conductance Regulator ◽  
Transmembrane Conductance ◽  
Cystic Fibrosis Transmembrane ◽  
Deficient Mice

scholarly journals Staphylococcus aureus Survives in Cystic Fibrosis Macrophages, Forming a Reservoir for Chronic Pneumonia

2017 ◽  
Vol 85 (5) ◽  
Author(s):  
Cao Li ◽  
Yuqing Wu ◽  
Andrea Riehle ◽  
Jie Ma ◽  
Markus Kamler ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Staphylococcus Aureus ◽  
Intracellular Bacteria ◽  
Transmembrane Conductance Regulator ◽  
Pulmonary Infections ◽  
Wild Type ◽  
Transmembrane Conductance ◽  
Content Type ◽  
Cystic Fibrosis Transmembrane ◽  
Chronic Pneumonia

ABSTRACT Staphylococcus aureus plays an important role in sepsis, pneumonia, wound infections, and cystic fibrosis (CF), which is caused by mutations of the cystic fibrosis transmembrane conductance regulator (Cftr). Pulmonary S. aureus infections in CF often occur very early and prior to colonization with other pathogens, in particular Pseudomonas aeruginosa. Here, we demonstrate that CF mice are highly susceptible to pulmonary infections with S. aureus and fail to clear the pathogen during infection. S. aureus is internalized by Cftr-deficient macrophages in the lung, but these macrophages are unable to kill intracellular bacteria. This failure might be caused by a defect in the fusion of phagosomes with lysosomes, while this process occurs rapidly in wild-type macrophages and serves to kill intracellular pathogens. Transplantation of infected Cftr-deficient alveolar macrophages into the lungs of noninfected CF mice is sufficient to induce pneumonia. This suggests that intracellular survival of S. aureus in macrophages may allow the pathogen to chronically infect CF lungs.

scholarly journals Nasal carriage of Staphylococcus aureus, including community-associated methicillin-resistant strains, in Queensland adults

2009 ◽  
Vol 15 (2) ◽  
pp. 149-155 ◽  
Author(s):  
W.J. Munckhof ◽  
G.R. Nimmo ◽  
J.M. Schooneveldt ◽  
S. Schlebusch ◽  
A.J. Stephens ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Nasal Carriage ◽  
Methicillin Resistant ◽  
Resistant Strains

scholarly journals Congenital tracheal malformation in cystic fibrosis transmembrane conductance regulator-deficient mice

2008 ◽  
Vol 586 (13) ◽  
pp. 3231-3243 ◽  
Author(s):  
Elise Bonvin ◽  
Philippe Le Rouzic ◽  
Jean-François Bernaudin ◽  
Charles-Henry Cottart ◽  
Clarisse Vandebrouck ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Transmembrane Conductance Regulator ◽  
Transmembrane Conductance ◽  
Cystic Fibrosis Transmembrane ◽  
Deficient Mice
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