scholarly journals Genomic and Phylogenetic Characterization of Brazilian Yellow Fever Virus Strains

2012 ◽  
Vol 86 (24) ◽  
pp. 13263-13271 ◽  
Author(s):  
M. R. T. Nunes ◽  
G. Palacios ◽  
J. F. Cardoso ◽  
L. C. Martins ◽  
E. C. Sousa ◽  
...  
Virology ◽  
2005 ◽  
Vol 342 (2) ◽  
pp. 167-176 ◽  
Author(s):  
Svetlana F. Khaiboullina ◽  
Albert A. Rizvanov ◽  
Michael R. Holbrook ◽  
Stephen St. Jeor

2008 ◽  
Vol 8 (5) ◽  
pp. 675-688 ◽  
Author(s):  
Kate L. McElroy ◽  
Yvette A. Girard ◽  
Charles E. McGee ◽  
Konstantin A. Tsetsarkin ◽  
Dana L. Vanlandingham ◽  
...  

2004 ◽  
Vol 37 (suppl 2) ◽  
pp. 69-74 ◽  
Author(s):  
Sueli Guerreiro Rodrigues ◽  
Amélia Paes de Andrade Travassos da Rosa ◽  
Ricardo Galler ◽  
Vera Lúcia Reis de Souza Barros ◽  
Conceição de Maria Almeida Vieira ◽  
...  

In order to investigate the pathogenicity of the virus strain GOI 4191 that was isolated from a fatal adverse event after yellow fever virus (YFV) vaccination, an experimental assay using hamsters (Mesocricetus auratus) as animal model and YFV 17DD vaccine strain as virus reference was accomplished. The two virus strains were inoculated by intracerebral, intrahepatic and subcutaneous routes. The levels of viremia, antibody response, and aminotransferases were determined in sera; while virus, antigen and histopathological changes were determined in the viscera. No viremia was detected for either strain following infection; the immune response was demonstrated to be more effective to strain GOI 4191; and no significant aminotransferase levels alterations were detected. Strain GOI 4191 was recovered only from the brain of animals inoculated by the IC route. Viral antigens were detected in liver and brain by immunohistochemical assay. Histothological changes in the viscera were characterized by inflammatory infiltrate, hepatocellular necrosis, and viral encephalitis. Histological alterations and detection of viral antigen were observed in the liver of animals inoculated by the intrahepatic route. These findings were similar for both strains used in the experiment; however, significant differences were observed from those results previously reported for wild type YFV strains.


2002 ◽  
Vol 68 (4) ◽  
pp. 620-627 ◽  
Author(s):  
A.M.B. de Filippis ◽  
R.M.R. Nogueira ◽  
H.G. Schatzmayr ◽  
D.S. Tavares ◽  
A.V. Jabor ◽  
...  

2017 ◽  
Vol 89 (3 suppl) ◽  
pp. 2119-2130 ◽  
Author(s):  
TELISSA C. KASSAR ◽  
TEREZA MAGALHÃES ◽  
JOSÉ V.J. S. JÚNIOR ◽  
AMANDA G.O. CARVALHO ◽  
ANDRÉA N.M.R. DA SILVA ◽  
...  

Acta Tropica ◽  
2017 ◽  
Vol 166 ◽  
pp. 114-120 ◽  
Author(s):  
Taissa Ricciardi Jorge ◽  
Ana Luiza Pamplona Mosimann ◽  
Lucia de Noronha ◽  
Angela Maron ◽  
Claudia Nunes Duarte dos Santos

Viruses ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1383
Author(s):  
Emily H. Davis ◽  
Jill K. Thompson ◽  
Steven G. Widen ◽  
Alan D. T. Barrett

The yellow fever virus vaccine, 17D, was derived through the serial passage of the wild-type (WT) strain Asibi virus in mouse and chicken tissue. Since its derivation, the mechanism of attenuation of 17D virus has been investigated using three 17D substrains and WT Asibi virus. Although all three substrains of 17D have been sequenced, only one isolate of Asibi has been examined genetically and all interpretation of attenuation is based on this one isolate. Here, we sequenced the genome of Asibi virus from three different laboratories and show that the WT strain is genetically homogenous at the amino acids that distinguish Asibi from 17D vaccine virus.


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