Properties of the human hepatitis B virus enhancer: position effects and cell-type nonspecificity.

1988 ◽  
Vol 62 (4) ◽  
pp. 1305-1313 ◽  
Author(s):  
J L Vannice ◽  
A D Levinson
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Cell Type ◽  
Position Effects ◽  
Human Hepatitis ◽  
B Virus

scholarly journals Inhibitory effects of selected antiviral compounds on human hepatitis B virus DNA synthesis.

1991 ◽  
Vol 35 (2) ◽  
pp. 394-397 ◽  
Author(s):  
T Yokota ◽  
S Mochizuki ◽  
K Konno ◽  
S Mori ◽  
S Shigeta ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Dna Synthesis ◽  
Inhibitory Effects ◽  
Hepatitis B Virus Dna ◽  
Antiviral Compounds ◽  
Human Hepatitis ◽  
B Virus

Molecular approaches to validate disinfectants against human hepatitis B virus

2002 ◽  
Vol 190 (4) ◽  
pp. 189-197 ◽  
Author(s):  
C. Jursch ◽  
W. Gerlich ◽  
D. Glebe ◽  
S. Schaefer ◽  
O. Marie ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Molecular Approaches ◽  
Human Hepatitis ◽  
B Virus

scholarly journals Activation of ERAD Pathway by Human Hepatitis B Virus Modulates Viral and Subviral Particle Production

PLoS ONE ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. e34169 ◽  
Author(s):  
Catalin Lazar ◽  
Alina Macovei ◽  
Stefana Petrescu ◽  
Norica Branza-Nichita
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Particle Production ◽  
Human Hepatitis ◽  
B Virus ◽  
Subviral Particle ◽  
Erad Pathway

scholarly journals PP-074 Prevalence of a virus similar to human hepatitis B virus in swine

2009 ◽  
Vol 13 ◽  
pp. S69
Author(s):  
Wengui Li ◽  
Ruiping She ◽  
Liqiang Liu ◽  
Quan Sun
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Human Hepatitis ◽  
B Virus

scholarly journals Activation of Hepatitis B Virus S Promoter by a Cell Type-Restricted IRE1-Dependent Pathway Induced by Endoplasmic Reticulum Stress

2005 ◽  
Vol 25 (17) ◽  
pp. 7522-7533 ◽  
Author(s):  
Zhi-Ming Huang ◽  
Thomas Tan ◽  
Hiderou Yoshida ◽  
Kazutoshi Mori ◽  
Yanjun Ma ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Er Stress ◽  
Transcriptional Activation ◽  
Active Form ◽  
Dominant Negative ◽  
Dependent Manner ◽  
Cell Type ◽  
B Virus

ABSTRACT IRE1-alpha is an integral membrane protein of the endoplasmic reticulum (ER) that is a key sensor in the cellular transcriptional response to stress in the ER. Upon induction of ER stress, IRE1-alpha is activated, resulting in the synthesis of the active form of the transcription factor XBP1 via IRE1-mediated splicing of its mRNA. In this report, we have examined the role of IRE1-alpha and XBP1 in activation of the hepatitis B virus S promoter by ER stress. Cotransfection experiments revealed that overexpression of either IRE1-alpha or XBP1 activated this promoter. Conversely, cotransfected dominant-negative IRE1-alpha or small interfering RNA directed against XBP1 decreased the activation of the S promoter by ER stress, confirming an important role for the IRE1-alpha/XBP1 signaling pathway in activation of the S promoter. However, XBP1 does not bind directly to the S promoter; rather, a novel S promoter-binding complex that does not contain XBP1 is induced in cells undergoing ER stress in an XBP1-dependent manner. This complex, as well as transcriptional activation of the S promoter, is induced by ER stress in hepatocytes but not in fibroblasts, despite the presence of active XBP1 in the latter. Thus, the hepatitis B virus S promoter responds to a novel, cell type-restricted transcriptional pathway downstream of IRE1-alpha and XBP1.

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