The K-bZIP Protein from Kaposi's Sarcoma-Associated Herpesvirus Interacts with p53 and Represses Its Transcriptional Activity
2000 ◽
Vol 74
(24)
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pp. 11977-11982
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Keyword(s):
ABSTRACT Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that has been implicated in the pathogenesis of Kaposi's sarcoma. KSHV encodes K-bZIP (open reading frame K8), a protein that belongs to the basic region-leucine zipper (bZIP) family of transcription factors. Here we show that K-bZIP associates with the cellular transcription factor p53 directly in vitro and in vivo. This interaction requires the bZIP domain of K-bZIP and the carboxy-terminal region (amino acids 300 to 393) of p53. We also show that K-bZIP represses the transcriptional activity of p53 which is required for apoptosis of the host cell. These results imply that K-bZIP blocks p53-mediated host cell death through its interaction with p53.
2001 ◽
Vol 12
(12)
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pp. 3987-3999
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2004 ◽
Vol 78
(16)
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pp. 8878-8884
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2006 ◽
Vol 80
(6)
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pp. 2958-2967
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2004 ◽
Vol 78
(19)
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pp. 10336-10347
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2006 ◽
Vol 87
(5)
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pp. 1139-1144
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2003 ◽
Vol 84
(3)
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pp. 665-676
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