The Ribosome Binding Site of Hepatitis C Virus mRNA
2001 ◽
Vol 75
(16)
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pp. 7629-7636
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Keyword(s):
ABSTRACT Hepatitis C virus (HCV) infects an estimated 170 million people worldwide, the majority of whom develop a chronic infection which can lead to severe liver disease, and for which no generally effective treatment yet exists. A promising target for treatment is the internal ribosome entry site (IRES) of HCV, a highly conserved domain within a highly variable RNA. Never before have the ribosome binding sites of any IRES domains, cellular or viral, been directly characterized. Here, we reveal that the HCV IRES sequences most closely associated with 80S ribosomes during protein synthesis initiation are a series of discontinuous domains together comprising by far the largest ribosome binding site yet discovered.
2004 ◽
Vol 78
(21)
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pp. 12075-12081
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Keyword(s):
2006 ◽
Vol 80
(3)
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pp. 1271-1279
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Keyword(s):
2006 ◽
Vol 87
(11)
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pp. 3251-3262
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Keyword(s):
2007 ◽
Vol 88
(7)
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pp. 1992-2002
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2001 ◽
Vol 21
(24)
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pp. 8357-8364
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2000 ◽
Vol 74
(22)
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pp. 10430-10437
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Keyword(s):
2003 ◽
Vol 84
(3)
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pp. 535-543
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2004 ◽
Vol 78
(9)
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pp. 4487-4497
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